A5026933489- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Ovarian cancer diagnosis and treatment
- Cardiac Fibrosis and Remodeling
- Physical Activity and Health
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Biochemical Acid Research Studies
- Protein Kinase Regulation and GTPase Signaling
- RNA Research and Splicing
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Muscle metabolism and nutrition
- GDF15 and Related Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Intraperitoneal and Appendiceal Malignancies
- Immune Cell Function and Interaction
Baker Heart and Diabetes Institute
2014-2025
Japanese Red Cross Society Wakayama Medical Center
2021
Komatsu (Japan)
2021
Fuji Electric (Japan)
2020
University of Tokyo Hospital
2018
Tokyo University of Science
2017
Keio University Shonan Fujisawa
2016
Doshisha University
2016
The University of Queensland
2008-2012
The University of Melbourne
2012
Exercise increases the production of reactive oxygen species (ROS) in skeletal muscle, and athletes often consume antioxidant supplements belief they will attenuate ROS-related muscle damage fatigue during exercise. However, exercise-induced ROS may regulate beneficial adaptations, such as increased mitochondrial biogenesis. We therefore investigated effects long-term supplementation with vitamin E α-lipoic acid on changes markers biogenesis exercise-trained sedentary rats.Male Wistar rats...
Background— Numerous molecular and biochemical changes have been linked with the cardioprotective effects of exercise, including increases in antioxidant enzymes, heat shock proteins, regulators cardiac myocyte proliferation. However, a master regulator exercise-induced protection has yet to be identified. Here, we assess whether phosphoinositide 3-kinase (PI3K) p110α is essential for mediating cardioprotection, if so, its activation independent exercise can restore function failing heart....
According to the World Health Organization Expert Consultation, current body mass index (BMI) cut-offs should be retained as an international classification. However, there are ethnic differences in BMI-associated health risks that may caused by fat or skeletal muscle and these affect interpretation of phase angle bioelectrical impedance vector analysis (BIVA). Therefore, aim this study was compare composition measured among 1048 German, 1026 Mexican, 995 Japanese adults encompassing a wide...
Cardiac intercellular communication is critical for heart function and often dysregulated in cardiovascular diseases. While cardiac extracellular vesicles (cEVs) are emerging mediators of signalling, their isolation remains a technical challenge hindering our understanding cEV protein composition. Here, we utilised Langendorff-collagenase-based enzymatic perfusion differential centrifugation to isolate cEVs from mouse (yield 3-6 μg/heart). ∼200 nm, express classical EV markers (Cd63/81/9+ ,...
MicroRNA (miRNA)-based therapies are in development for numerous diseases, including heart disease. Currently, very limited basic information is available on the regulation of specific miRNAs male and female hearts settings The identification sex-specific miRNA signatures has implications translation into clinic suggests need customised therapy. In present study, we found that a miRNA-based treatment inhibiting miRNA-34a (miR-34a) was more effective females setting moderate dilated...
The insulin-like growth factor 1 receptor (IGF1R) and phosphoinositide 3-kinase p110α (PI3K) are critical regulators of exercise-induced physiological cardiac hypertrophy provide protection in experimental models pathological remodeling heart failure. Forkhead box class O1 (FoxO1) is a transcription that regulates cardiomyocyte downstream IGF1R/PI3K activation vitro, but its role vivo was unknown. We generated cardiomyocyte-specific FoxO1 knockout (cKO) mice assessed the phenotype under...
Abstract Atrial fibrillation (AF) remains challenging to prevent and treat. A key feature of AF is atrial enlargement. However, not all enlargement progresses AF. in response physiological stimuli such as exercise typically benign reversible. Understanding the differences function molecular profile underpinning pathological remodelling will be critical for identifying new strategies The discovery mechanisms responsible ventricular hypertrophy has uncovered drug targets heart failure. Studies...
Elucidating mechanisms underlying atrial myopathy, which predisposes individuals to fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase (PI3K) cardiomyocytes. PI3K(p110α) is elevated the heart exercise exercise-induced ventricular enlargement protection, but role atria was unknown. Physical inactivity extreme endurance can increase AF risk. Therefore, our...
In order to examine the feasibility of power generation by using friction-induced vibration with a piezoelectric element, we performed experiments and numerical analysis. experiments, generated in element displacement an oscillator were measured newly developed apparatus that embodied single-degree-of-freedom (1-DOF) system friction. analysis, analytical model 1-DOF friction was proposed simulate experiments. The experimental results demonstrated few microwatts sliding between steel ball...
For many patients clinical prescription of walking will be beneficial to health and accelerometers can used monitor their intensity, frequency duration over days. Walking intensity should include establishment individual specific accelerometer count, speed energy expenditure (VO2) relationships this achieved using a protocol on treadmill or overground. However, differences in gait mechanics during compared overground may result inaccurate estimations free-living VO2. The aims study were...
We investigated the relationship between markers of mitochondrial biogenesis, cell signaling, and antioxidant enzymes by depleting skeletal muscle glutathione with diethyl maleate (DEM) which resulted in a demonstrable increase oxidative stress during exercise. Animals were divided into six groups: (1) sedentary control rats; (2) rats + DEM; (3) exercise euthanized immediately after exercise; (4) (5) 4 h (6) DEM Exercising animals ran on treadmill at 10% gradient 20 m/min for first 30 min....
We investigated the distribution of endothelin A (ETA) receptor-like immunoreactivity in rat kidney using affinity-purified antibodies against amino acid residues 403-417 ETA receptor modified by multiple antigen peptide complex system. Western blot analysis anti-ETA antibody detected bands approximately 47.3 and 64.5 kDa kidney. By light microscopy, was seen basal side renal tubules collecting ducts. The most intense present distal inner medullary In addition to infoldings, immunoreactive...
Combining thalidomide (Thal) with chemotherapeutic agents or steroid preparations led to improved response rates in the treatment of multiple myeloma. However, deep vein thrombosis (DVT) is one most serious side-effects noted this regimen, and how a Thal-based regimen causes DVT unclear. We investigated procoagulant effects Thal when combined vitro, focusing on tissue factor (TF) phosphatidylserine. examined doxorubicin hydrochloride (Dox) dexamethasone (Dex), without Thal. Our study used...
Abstract Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue‐specific expression and presentation monomorphic antigens. These characteristics tend to imbue class MHC with unique functions. H2‐Q10 potentially one such molecule that overexpressed in the liver but its immunological function not known. We have previously shown a ligand for natural killer cell receptor Ly49C now, using H2‐Q10‐deficient mice, we can also stabilize Qa‐1b. In...
Nightly extended hours hemodialysis may improve left ventricular hypertrophy and function endothelial but presents problems of sustainability increased cost. The effect alternate nightly home (NHD) on cardiovascular structure is not known. Sixty-three patients standard (SHD: 3.5-6 hours/session, 3-5 sessions weekly) converted to NHD (6-10 hours/session overnight for weekly). 2Dimensional transthoracic echocardiography ultrasound measures brachial artery reactivity (BAR), carotid intima-media...