A5089104513- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Biochemical Acid Research Studies
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Berberine and alkaloids research
- Catalytic C–H Functionalization Methods
- Medicinal Plants and Neuroprotection
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Biochemical effects in animals
- Alkaloids: synthesis and pharmacology
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Plant-based Medicinal Research
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Nuclear Receptors and Signaling
Sun Yat-sen University
2015-2024
Hong Kong Polytechnic University
2018
SYSU-CMU International Joint Research Institute
2015-2017
Guangzhou Experimental Station
2014
Sun Yat-sen Memorial Hospital
2013
University of Auckland
2007
Hong Kong University of Science and Technology
2004
University of Hong Kong
2004
Abstract Carbazoles have attracted high interest among synthetic chemists due to their unique structural features and potential pharmacological activities. Compared linear aryliodoniums, cyclic diphenyleneiodoniums are more inert not much attention application as building blocks. Employing our strategy, diversified carbazoles can be efficiently obtained from a single diphenyleneiodonium under mild conditions. The reactions catalyzed by copper(II) acetate provided variety of in modest good...
Linear iodoniums are widely used as arylating reagents. However, cyclic diaryl idodoniums ignored despite their potential to initiate dual arylations, atom and step economically. In our current work, a three-component cascade reaction of diaryliodoniums, sodium azide, alkynes has been successfully achieved under mild conditions, catalyzed by cheap copper species. The regioselectivity associated with unsymmetrical was enhanced installing two methyls ortho para the I(III) center. enables rapid...
Abstract Minocycline has been shown to have remarkably neuroprotective qualities, but underlying mechanisms remain elusive. We reported here the robust neuroprotection by minocycline against glutamate‐induced apoptosis through regulations of p38 and Akt pathways. Pre‐treatment cerebellar granule neurons (CGNs) with (10–100 µ m ) elicited a dose‐dependent reduction glutamate excitotoxicity blocked nuclear condensation DNA fragmentations. Using patch‐clamping fluorescence Ca 2+ imaging...
Background Berberine, an isoquinoline derivative alkaloid, has a wide range of pharmacological properties and is considered to have anti-inflammatory neuroprotective effects. However, there are no reports about the effects mechanisms berberine in experimental autoimmune encephalomyelitis (EAE), established model multiple sclerosis (MS). Methodology/Principal Findings Female C57 BL/6 mice immunized with myelin oligodendrocyte glycoprotein 35–55 amino acid peptide were treated at day disease...
We have previously synthesized a series of hybrid compounds by linking ferulic acid to tacrine as multifunctional agents based on the hypotheses that Alzheimer's disease (AD) generates cholinergic deficiency and oxidative stress. Interestingly, we found they may potential pharmacological activities for treating AD. Here report first time tacrine-6-ferulic (T6FA), one these compounds, can prevent amyloid-β peptide (Aβ)-induced AD-associated pathological changes in vitro vivo. Our results...
Summary Aims Oxidative stress is frequently implicated in the pathology of neurodegenerative diseases. This study aimed to investigate effects and their underlying mechanism(s) edaravone upon hydrogen peroxide (H 2 O )–induced oxidative apoptosis HT 22 cells, a murine hippocampal neuronal model. Methods cells were treated with H presence various concentrations or its absence. A CCK ‐8 assay, Hoechst 33342 staining, flow cytometry used detect cytotoxicity apoptosis. In addition, levels...
Sirtuin 6 (SIRT6) is involved in regulation of glucose and fat metabolism. However, its possible contribution to cardiac dysfunction remains be determined. In the present study, effect SIRT6 on hypertrophy induced by angiotensin II (AngII) underlying molecular mechanisms were investigated.The expression deacetylase activity measured hypertrophic cardiomyocytes AngII. After overexpression transfection, or depletion RNA interference neonatal rat cardiomyocytes, cellular was monitored measuring...
The discovery of sirtuins (SIRT), a family nicotinamide adenine dinucleotide (NAD)‐dependent deacetylases, has indicated that intracellular NAD level is crucial for the hypertrophic response cardiomyocytes. Nicotinamide mononucleotide adenylyltransferase (Nmnat) central enzyme in biosynthesis. Here we revealed Nmnat2 protein expression and activity were down‐regulated during cardiac hypertrophy. In neonatal rat cardiomyocytes, overexpression but not its catalytically inactive mutant blocked...
Linear diaryliodonium salts are widely used as arylating reagents for C–C and C–X bond formation. Meanwhile, synthetic applications of cyclic iodoniums relatively rare although they offer the opportunity to set up reaction cascades. We demonstrate an atom step economical three-component involving diphenyleneiodoniums, alkynes, boronic acids, resulting in construction methylidenefluorenes a single operation. Our route enables facile access both symmetrical unsymmetrical methylidenefluorene...