A5037178537- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Effects of Radiation Exposure
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Circular RNAs in diseases
- Psoriasis: Treatment and Pathogenesis
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Biochemical effects in animals
- Glycosylation and Glycoproteins Research
- Renal Diseases and Glomerulopathies
- Head and Neck Cancer Studies
- Cell death mechanisms and regulation
- Natural Compounds in Disease Treatment
- Asthma and respiratory diseases
- Heat shock proteins research
- Mast cells and histamine
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Sun Yat-sen University
2008-2024
Zhongshan Ophthalmic Center, Sun Yat-sen University
2023-2024
First Affiliated Hospital of Gannan Medical University
2023-2024
Sichuan Academy of Forestry
2024
Sichuan Agricultural University
2024
Army Medical University
2007-2023
Beijing Tongren Hospital
2022
In a previous paper, we reported that triptolide (TP), commonly used immunomodulator, could attenuate cardiac hypertrophy. This present study aimed to further explore the inhibition of fibrosis by TP and possible mechanism from perspective NOD-like receptor protein 3 (NLRP3) inflammasome. Hematoxylin-eosin Masson's staining, immunohistochemistry, immunofluorescence were performed observe fibrotic changes in mice mouse fibroblasts (CFs). The Western blot, colocalization, immunoprecipitation...
Radiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the present study, we attempted to evaluate effect of Magnesium isoglycyrrhizinate (MgIG) on RIPF, and further explore underlying mechanisms. We found that MgIG treatment markedly improved radiation-induced lung pathological changes, reduced collagen deposition, decreased transforming growth factor beta1 (TGF-β1)...
Breast cancer (BC) negatively impacts the health of women worldwide. Circular RNAs (circRNAs) are a group endogenous considered essential regulatory factor in BC tumorigenesis and progression. However, underlying molecular mechanisms circRNAs remain unclear.Expression levels circPAPD4, miR-1269a, CREBZF, ADAR1 cell lines tissues were measured using bioinformatics analysis, RT-qPCR, ISH, IHC. Cell proliferation apoptosis CCK8, EdU staining, flow cytometry, TUNEL assays. Pearson correlation...
Vision loss is a leading cause of healthy life in late adulthood. We aimed to comprehensively examine the impact population aging on vision prevalence worldwide. This population-based study used repeated cross-sectional data and its related causes from Global Burden Disease 2019 study. investigated by decomposing changes into contributions growth, aging, epidemiological rate using latest decomposition method comparing net effect changes. The global attributed increased 1991 2019, reaching...
Abstract Objectives This study aimed to investigate the possible modification of neuroprotective effect sodium ferulate, when orally co-administered with borneol, in transient global cerebral ischaemia-induced functional, histological and cellular alterations mice. Methods The bilateral common carotid artery occlusion was conducted C57 BL/6J mice for 25 min. were then subjected a water maze test over an extended recovery period, followed by assessment neuronal loss CA1 region hippocampus...
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential improve lung fibrosis and cancer. To avoid liver kidney toxicities fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared their characteristics studied. ED-PLA-MS by organic phase dispersion-solvent diffusion method. By applying an orthogonal design, our results indicated that optimal formulation was 12 mg/mL PLA, 0.5% gelatin, phase:glycerol ratio 1:20. Using...
Radiation-induced lung fibrosis (RILF) is a long-term adverse effect of curative radiotherapy. The accumulation myofibroblasts in fibroblastic foci pivotal feature RILF. In the study, we found inhibitory grape seed proanthocyanidins (GSPs) on irradiation-induced differentiation human fetal fibroblasts (HFL1). To explore mechanism by which GSPs inhibit fibroblast differentiation, measured reactive oxygen species (ROS) levels, mitochondrial function, dynamics, glycolysis and signaling...
The forkhead/winged helix transcription factor (Fox) p3 can regulate the expression of various genes, and it has been reported that transfer Foxp3-positive T cells could ameliorate cardiac hypertrophy fibrosis. Triptolide (TP) elevate Foxp3, but its effects on remain unclear. In present study, neonatal rat ventricular myocytes (NRVM) were isolated stimulated with angiotensin II (1 μmol/L) to induce hypertrophic response. Foxp3 in NRVM was observed by using immunofluorescence assay. Fifty...
Psoriasis is a chronic inflammatory disease whose etiology directly related to the dysregulation of cutaneous immune homeostasis. However, how finely modulate skin microenvironment restore homeostasis remains an important challenge. Inspired by natural attribute tumor exosomes in escape, tumor-derived as active targeting nanoplatform for effective treatment disorder were first reported. As keratinocytes and cells express high PD-1 during onset psoriasiform inflammation, PD-L1-positive...
Background/Objectives: Compelling evidence indicates a significant role for population of CD4+ T regulatory cells in suppressing immune responses and maintaining immunological homeostasis. This study aims to investigate the potential CD4+CD25HIGHFOXP3+ patients with chronic autoimmune urticaria define characteristics urticaria. Methods: We used flow cytometry assess expression peripheral blood mononuclear Results: In this study, we found that have significantly reduced frequency (1.39 ±...
Abstract Introduction Hemodialysis (HD) patients are under observably elevated cardiovascular mortality. Cardiac dysfunction is closely related to death caused by diseases (CVD). In the general population, repetitive myocardial ischemia induced left ventricular (LV) may progress irreversible loss of contraction step step, and finally lead cardiac death. HD patients, remove water solute accumulated from 48 or 72 hours interdialysis period in a 4‐hour session will induce ischemia. this study,...
Accumulated research has revealed that the abnormal expression of microRNAs play a crucial role in tumorigenesis, potentially serving as therapeutic biomarkers multiple tumors including cervical cancer. However, level, biological and underlying mechanism miRNA-143 cancer remain unclear. In current study, we analyzed golgi membrane protein 1 (GOLM1) tissues cells to explore their effects on occurrence metastasis. Reverse transcription-quantitative PCR (RT-qPCR) was used detect cells....