A5022274692- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Mesenchymal stem cell research
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Neurological Complications and Syndromes
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Hematopoietic Stem Cell Transplantation
- Intraocular Surgery and Lenses
- Cytomegalovirus and herpesvirus research
- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- Angiogenesis and VEGF in Cancer
Second Affiliated Hospital of Fujian Medical University
2011-2024
Fujian Medical University
2011-2024
Zhujiang Hospital
2010-2024
Southern Medical University
2010-2024
ORCID
2024
Hubei University Of Economics
2023
Tang Hospital
2020
Zhongshan Ophthalmic Center, Sun Yat-sen University
2008-2018
Cytoskeleton (United States)
2018
Sun Yat-sen University
2008-2018
CC-Cruiser is an artificial intelligence (AI) platform developed for diagnosing childhood cataracts and providing risk stratification treatment recommendations. The high accuracy of was previously validated using specific datasets. objective this study to compare the diagnostic efficacy decision-making capacity between ophthalmologists in real-world clinical settings.This multicentre randomized controlled trial performed five ophthalmic clinics different areas across China. Pediatric...
Abstract Background Kidneys from deceased donors are being used to meet the growing need for grafts. However, delayed graft function (DGF) and acute rejection incidences high, leading adverse effects on outcomes. Optimal induction intervention should include both renal structure injury repair immune response suppression. Mesenchymal stem cells (MSCs) with potent anti-inflammatory, regenerative, immune-modulatory properties considered a candidate prevent DGF in transplantation. Thus, this...
The studies on the association between sleep duration and myopia are limited, evidence is inconsistent. This study aimed to evaluate myopia, cycloplegic spherical equivalent (SE) axial length (AL) among Chinese children during Corona Virus Disease 2019 (COVID-19) pandemic. was a cross-sectional aged 6-18 years. comprehensive ophthalmic examinations for included SE, AL, standardized questionnaires. questionnaire duration, parental outdoor time, continuous near work without breaks. Myopia...
The development of myopia is associated with scleral remodeling, but it unclear which factors regulate this process. This study investigated bone morphogenetic protein-2 (BMP-2) expression in the sclera guinea pigs lens-induced (LIM) and after recovery from evaluated effect BMP-2 on extracellular matrix (ECM) synthesis human fibroblasts (HSFs) cultured vitro. Lens-induced was brought about two groups (the groups) by placing -4.00 D lenses right eye for three weeks. left served as a...
The aim of this study was to determine the effect adenosine receptor antagonist 7-methylxanthine (7-MX) on form deprivation myopia in 3-week-old guinea pigs.Two groups pigs were subjected monocular (MD) using a diffuser and fed either 7-MX (300 mg/kg body weight; n = 7) or vehicle control (saline at an equal volume 7-MX; 7). A group (n 6) not deprivation. Ocular refraction, axial length weight measured start after 21 days. thickness posterior sclera by light microscopy collagen fibril...
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential improve lung fibrosis and cancer. To avoid liver kidney toxicities fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared their characteristics studied. ED-PLA-MS by organic phase dispersion-solvent diffusion method. By applying an orthogonal design, our results indicated that optimal formulation was 12 mg/mL PLA, 0.5% gelatin, phase:glycerol ratio 1:20. Using...
Highlights•PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability•PPR could enter renal tubular cells and then release rutin to eliminate ROS•PPR alleviate IRI damage by repairing mitochondria suppressing ferroptosisSummaryKidney transplantation is essential for patients end-stage disease; however, ischemia-reperfusion injury (IRI) during can lead acute kidney compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic...
Dependence of hormone binding to glucocorticoid receptors (GRs) on cellular ATP levels suggested that GRs traverse an ATP-dependent cycle, and without accumulate in forms cannot bind hormone. Such null (NRs) were identified ATP-depleted WEHI-7 cells, where they are tightly associated with the nuclear fraction partly dephosphorylated. With WCL2 cells (Chinese hamster ovary overexpressed GRs) depleted azide, we have now dephosphorylated sites NRs, studied possible roles phosphorylation using...
The brain network is an effective tool and has been widely used in the field of neurodegenerative disease analysis. Due to high cost accessing medical image data, efforts have devoted investigating data augmentation. However, containing topological characteristics non-European space different from traditional which makes it challenging synthesize structural connectivity limits application In this paper, a Hemisphere-separated Cross-connectome Aggregating Learning (HCAL) model proposed...
Myopia, the most prevalent eye condition, has sparked notable interest regarding its origin and prevention. MicroRNAs (miRNAs) are short, non-coding RNA strands typically consisting of 18-24 nucleotides. They play a central role in post-transcriptional gene regulation closely associated with both normal pathological processes organisms. Recent advances next-generation sequencing bioinformatics have provided novel insights into miRNA expression regulatory myopia. This review discusses...
Abstract An increasing number of experiments and clinical trials have demonstrated the safety, feasibility, efficacy mesenchymal stem cells (MSCs)‐based therapies for treatment various diseases. The main drawbacks MSC therapy are lack specific homing after systemic infusion early death injected because injury micro‐environment. We pretreated bone (BMSCs) with erythropoietin (EPO) to investigate their positive effect on cyclosporine A (CsA)‐induced nephrotoxicity. BMSCs were incubated...
Kidney transplantation is currently the first choice of treatment for various types end-stage renal failure, but there are major limitations in application immunosuppressive protocols after kidney transplantation. When dose immunosuppressant too low, graft rejection occurs easily, while a that high can lead to loss. Therefore, it very important explore immune status patients receiving agents To compare recipient’s whole peripheral blood before and receipt agents, we used single-cell...
Purpose: To report the authors’ experience using fluocinolone acetonide (Retisert) to treat cystoid macular edema (CME) resulting from immune recovery uveitis (IRU) in 2 acquired immunodeficiency syndrome (AIDS) patients with a history of cytomegalovirus (CMV) retinitis.Design: Interventional case series.Methods: Medical records were reviewed who received Retisert implantation 3 eyes for IRU-associated inflammation and CME. Suppression CMV disease was achieved oral medication one patient...
Purpose: To elucidate the influence of dopamine receptor 1 (DRD1) on proliferation mouse corneal epithelial cells (MCECs) under inflammatory conditions. Methods: In vitro, immortalized MCECs (iMCECs) were treated with IL-1β, and without pcDNA3.1_DRD1. Primary (pMCECs) exposed to DRD1 agonist (A68930). Cell was quantified using Counting Kit-8 (CCK-8) assay immunofluorescence staining for Ki-67 p63. Expression levels NOD-like protein 3 (NLRP3), IL-6 assessed. establish a injury model in mice,...
To explore the application of neural network models in artificial intelligence (AI)-aided devices fitting for low vision patients.The data 836 visually impaired people were collected southwestern Fujian from May 2014 to 2017. After a full eye examination, 629 patients selected this group. Based on visual functions, rehabilitation needs, and living quality scores patients, professionals chose assistive that best fit patients. The these three factors then subjected quantitative analysis,...