A5054341191- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- Photosynthetic Processes and Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Protein Degradation and Inhibitors
- Plant biochemistry and biosynthesis
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- interferon and immune responses
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
Chinese University of Hong Kong
2020-2024
Anhui Agricultural University
2024
Sun Yat-sen University
2015-2022
Sun Yat-sen University Cancer Center
2021
SYSU-CMU International Joint Research Institute
2015-2017
HDAC8 inhibition elicits durable responses to immune checkpoint blockade by improving adaptive through enhancer reprogramming.
Objective Therapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed investigate mechanisms underlying adaptation immune-checkpoint targeting. Design Two immunotherapy-resistant HCC models were generated by serial orthotopic implantation cells through anti-PD-L1-treated...
Traditional EZH2 inhibitors are developed to suppress the enzymatic methylation activity, and they may have therapeutic limitations due nonenzymatic functions of in cancer development. Here, we report proteolysis-target chimera (PROTAC)-based degraders target whole lymphoma. Two series were designed synthesized hijack E3 ligase systems containing either von Hippel–Lindau (VHL) or cereblon (CRBN), some VHL-based compounds able mediate degradation. best degraders, YM181 YM281, induced robust...
Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.
The cancer clinical therapy of doxorubicin (Dox) treatment is limited by its life-threatening cardiotoxic effects. Dickkopf-1 (Dkk1), the founding and best-studied member Dkk family, functions as an antagonist canonical Wnt/β-catenin. Dkk1 considered to play a broad role in variety biological processes, but effects on Dox-induced cardiomyopathy are poorly understood. Here, we found that level was significantly increased Dox-treated groups, this increase exacerbated cardiomyocyte apoptosis...
Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module that is associated with poor prognosis and aggressiveness of glioma. One the core members, Regulator chromatin condensation 2 (RCC2) component chromosome passenger complex. Accumulating evidence suggests RCC2 plays vital role in mitotic process abnormal expression involved cancer development. Gene silencing experiments show required for glioma cell proliferation migration. RNA-Sequencing reveals dual both...
Numerous studies have reported that glioma patients with isocitrate dehydrogenase 1(IDH1) R132H mutation are sensitive to temozolomide treatment. However, the mechanism of IDH1 mutations on chemosensitivity remains unclear. In this study, we investigated role and potential Nrf2 in R132H-mediated drug resistance.Wild type (R132H-WT) mutant (R132H) plasmids were constructed. Stable U87 cells U251 overexpressing generated. Phenotypic differences between IDH1-WT evaluated using MTT, cell colony...
As a plant-specific transcription factor, the vascular plant one-zinc-finger (VOZ) plays crucial role in regulating various biological processes. In this study, total of 17 VOZ genes Cucurbitaceae family were investigated using bioinformatics methods. The are distributed across 16 chromosomes. Based on affinity proteins to AtVOZ proteins, these categorized into two groups: group I encompassed eight members, while II comprised nine members. expression profiles CmoVOZs under hormonal and...
Glioblastoma multiforme (GBM) is the most malignant type of primary brain tumor in adults and can diffusely infiltrate adjacent normal tissue. GBM therefore rarely cured by surgery or radiation therapy. Matrix metalloproteinases (MMPs) are involved tissue remodeling numerous other physiological progresses. The MMPs MMP-2 MMP-9 associated with invasion ability GBM. PT93 a novel caffeic acid amide derivative that was first synthesized 2013. In present study, human T98G, U87 U251 cell lines...
A potently selective ROCK2 inhibitor with antioxidative properties.
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Abstract Background: Immune checkpoint blockade (ICB) therapies by antibodies have revolutionized the treatment paradigm for a variety of cancers. Although subsets people exhibit durable responses, resistance and relapse are common in hepatocellular carcinoma (HCC). We therefore aim to delineate mechanism underlying failure ICB therapy HCC, more importantly identify ICB-sensitizing therapeutic approaches. Methods: ICB-resistant orthotopic-grafted murine models were established via serial...
<h3>Background</h3> Immune checkpoint blockade (ICB) therapies by antibodies have revolutionized the treatment paradigm for a variety of cancers. Although subsets people exhibit durable responses, resistance and relapse are common in hepatocellular carcinoma (HCC). We, therefore, aim to delineate mechanism underlying failure ICB therapy HCC, more importantly, identify ICB-sensitizing therapeutic approaches. <h3>Methods</h3> ICB-resistant orthotopic-grafted murine models were established via...