A5038535560- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Neurological Disorders and Treatments
- Signaling Pathways in Disease
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Synthesis and biological activity
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- Calcium signaling and nucleotide metabolism
- Caveolin-1 and cellular processes
- Chemical synthesis and alkaloids
- Ion channel regulation and function
- Ginseng Biological Effects and Applications
- Phosphodiesterase function and regulation
- Berberine and alkaloids research
Hong Kong University of Science and Technology
2014-2024
University of Hong Kong
2014-2024
HKUST Shenzhen Research Institute
2020-2022
Hong Kong Polytechnic University
2012-2021
Shanxi University
2021
South China Agricultural University
2021
Shenzhen Polytechnic
2013-2020
Upsher-Smith Laboratories (United Kingdom)
2011
The non-classical function of acetylcholine (ACh) has been reported in neuroinflammation that represents the modulating factor immune responses via activation α7 nicotinic receptor (α7 nAChR), i.e., a cholinergic anti-inflammatory pathway (CAP). Acetylcholinesterase (AChE), an enzyme for ACh hydrolysis, proposed to have cells. However, involvement AChE is unclear. Here, cultured BV2 cell, microglial cell line, and primary microglia from rats were treated with lipopolysaccharide (LPS) induce...
Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function inflammatory responses. Here, the expression of PRiMA-linked G4 AChE was identified on surface macrophages. In lipopolysaccharide-induced processes, upregulated by binding NF-κB onto ACHE promotor. Conversely, overexpression inhibited ACh-suppressed cytokine release and cell...
SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection by against 1-methyl-4-phenylpyridinium ion (MPP(+) )-induced neurotoxicity further explored the underlying mechanisms.MPP(+) -treated neurons 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated zebrafish were used study SU4312. NOS...
SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this study, we have found the first time that unexpectedly prevented 1-methyl-4-phenylpyridinium ion (MPP+)-induced neuronal apoptosis in cerebellar granule neurons, decreased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss dopaminergic neurons impairment swimming behavior zebrafish concentration-dependent manner. However,...
Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC EHEC respectively) are attaching effacing bacterial pathogens that cause devastating diarrhoeal disease worldwide. These depend on a type III secretion system, which functions as molecular syringe to translocate effector proteins directly into infected host cells. One of these effectors, NleC, was recently described zinc metalloprotease targets NF-κB Rel-A (p65) thus contributes dampening inflammatory signalling during EPEC...
Summary Aims Oxidative stress ( OS ) plays an important role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease AD ). This study was designed to uncover cellular and biochemical mechanisms underlying neuroprotective effects tacrine‐3‐caffeic acid (T3 CA ), a novel promising multifunctional anti‐Alzheimer's dimer, against ‐induced neuronal death. Methods Results T 3 protected HT 22 cells high‐concentration‐glutamate‐induced cell death time‐...
Sunitinib, a tyrosine kinase inhibitor, is clinically used for the treatment of cancer. In this study, we found first time that sunitinib inhibits acetylcholinesterase (AChE) at submicromolar concentrations in vitro. addition, dramatically decreased hippocampal and cortical activity AChE time-dependent manner mice. Molecular docking analysis further demonstrates might interact with both catalytic anion peripheral anionic sites within AChE, which accordance enzymatic results showing mixed...
Rhynchophylline is a major tetracyclic oxindole alkaloid in Uncaria rhynchophylla, which has been extensively used as traditional herb medicine for the prevention of convulsions and hypertension. However, there still little evidence about neuroprotective effects rhynchophylline Parkinson's disease (PD), neurodegenerative condition currently without any effective cure. In this present study, molecular mechanisms were investigated cellular model associated with PD. It shown that (10-50 µM)...
Summary Background Sunitinib is an inhibitor of the multiple receptor tyrosine kinases ( RTK s) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, neuroprotective effects have not been reported. Methods Cerebellar granule neurons CGN and SH ‐ SY 5 Y cells were exposed to low‐potassium MPP + challenges, respectively. MTT assay, FDA / PI staining, H oechst DAF FM , colorimetric nitric oxide synthase NOS ) activity W estern...
Abstract β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented Aβ oligomers-induced inhibition long-term potentiation (LTP) at concentrations did not interfere with normal LTP. Bis(heptyl)-cognitin also synaptotoxicity primary hippocampal neurons. In contrast, tacrine and donepezil, typical AChE inhibitors,...
The over-activation of NMDA receptor via the excessive glutamate is believed to one most causal factors associated with Alzheimer's disease (AD), a progressive neurodegenerative brain disorder. Molecules that could protect against glutamate-induced neurotoxicity may hold therapeutic values for treating AD. Herein, neuroprotective mechanisms dimeric DT-010, novel derivative naturally occurring danshensu and tetramethylpyrazine, were investigated using primary rat cerebellar granule neurons...
Luteolin, a flavonoid in fruits and vegetables, has neurotrophic functions without well-characterized mechanism. Here, we hypothesize direct interaction of luteolin with nerve growth factor (NGF); as such, the functionality NGF could be potentiated. The binding was validated by ultra-filtration, Biacore, docking analyses. In cultured PC12 cells, application combination low dose potentiated NGF-induced differentiation neurons an increase differentiated cell number to 25.4 ± 4.8% (p < 0.01),...