A5041165505- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Legume Nitrogen Fixing Symbiosis
- Soybean genetics and cultivation
- Neuroinflammation and Neurodegeneration Mechanisms
- Force Microscopy Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
- Wheat and Barley Genetics and Pathology
- MicroRNA in disease regulation
- Plant Disease Resistance and Genetics
- Cancer-related molecular mechanisms research
- Neuroscience and Neural Engineering
- Lysosomal Storage Disorders Research
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Peroxisome Proliferator-Activated Receptors
- Neurogenesis and neuroplasticity mechanisms
- Drilling and Well Engineering
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Cardiovascular Health and Risk Factors
- Estrogen and related hormone effects
Ningbo University
2016-2025
Zhejiang University
2005-2025
Shaoxing People's Hospital
2025
Peking University
2025
Ningbo Medical Center Lihuili Hospital
2025
Heilongjiang University of Chinese Medicine
2016-2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
China Railway 18th Bureau Group Corporation
2023
Qilu Hospital of Shandong University
2022-2023
<title>Abstract</title> Background Brain and central nervous system cancer remains a major healthy concern among the elder worldwide. This study is performed to assess global burden of CNS adults aged ≥ 65 years across 204 countries territories from 1990 2021 predict future trends in next 25 years. Methods We analyzed incidence, mortality disability adjusted life (DALYs) based on data Global Burden Disease Study 2021. In addition, we obtained age-standardized incidence rate (ASIR),...
Abstract Perovskite solar cells (PSCs) have gained significant attention for their high efficiency, low cost, and versatile application possibilities, which are expected to play a critical role in shaping the future of photovoltaics (PV) markets. However, power conversion efficiency (PCE) stability large‐area PSCs still cannot meet industrialization requirements, mainly associated with unsatisfactory quality perovskite films. This review first identifies factors contributing film difference...
Background Abnormal lipid metabolism has been identified as a potential pathogenic mechanism of Alzheimer's disease (AD), which might be epigenetically regulated. Lysosomes are critical organelles for metabolism. However, the epigenetic modifications lysosome and regulating genes remain unclear in AD patients. Objective Explore role abnormal modifications, especially methylation metabolism-related AD. Methods Methylation beadchip MALDI-TOF mass spectrometry were used to detect genome-wide...
Sunitinib, a tyrosine kinase inhibitor, is clinically used for the treatment of cancer. In this study, we found first time that sunitinib inhibits acetylcholinesterase (AChE) at submicromolar concentrations in vitro. addition, dramatically decreased hippocampal and cortical activity AChE time-dependent manner mice. Molecular docking analysis further demonstrates might interact with both catalytic anion peripheral anionic sites within AChE, which accordance enzymatic results showing mixed...
Depression is a common neuropsychiatric disorder and new anti-depressive treatments are still in urgent demand. Fast Green FCF, safe biocompatible color additive, has been suggested to mitigate chronic pain. However, green FCF's effect on depression unknown. We aimed investigate lipopolysaccharide (LPS)-induced depressive-like behavior the underlying mechanisms. Pretreatment of FCF (100 mg/kg, i.p. daily for 7 days) alleviated LPS-treated mice. suppressed LPS-induced microglial astrocyte...
Rosiglitazone has been known to attenuate neurodegeneration in Alzheimer's disease (AD), but the underlying mechanisms remain be fully elucidated. In this study, living-cell image, immunocytochemistry, and electrophysiology were used examine effects of soluble amyloid-β protein (Aβ) oligomers rosiglitazone on synapse formation, plasticity, mitochondrial distribution cultured neurons. Incubation hippocampal cultures with (Aβ)42 (0.5 μM) for 3 h significantly decreased dendritic filopodium...
Abstract Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis Alzheimer's disease (AD). However, date, role Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown a mouse model AD. Here, we have developed injured hippocampal neurons induced by Aβ 42 oligomers vitro. We also investigated using recombinant plasmids‐induced inhibition or over‐expression. found that reduced exacerbated damage, whereas increased was...
First division restitution (FDR) in intergeneric Triticeae hybrids provides an important meiotic mechanism for the production of amphidiploids without use colchicine and similar chemicals. The genetic controls FDR were investigated by examining microsporogenesis fertility F 1 two- three-way crosses durum wheat (Triticum turgidum L. var. durum) cultivars Langdon (LDN) Golden Ball (GB), 'Gazelle' rye (Secale cereale L.), one accession (RL5286) Aegilops squarrosa results from two-way indicated...
Abstract Durum wheat ‘Langdon’(LDN) caused a high frequency of first‐division restitution (FDR) and partial fertility in hybrids with rye, Secale cereale L., Aegilops squarrosa L. In order to determine the genetic control FDR, complete set 14 Langdon durum D‐genome disomic substitution lines (LDNDS) was crossed ‘Gazelle’ rye one accession (RL5286) A. squarrosa. The microsporogenesis were studied. results showed that most expressed FDR fertility. However, 2D(2A), 4D(4A), 5D(5B) 6D(6B) both ,...
During the production of Triticum-Aegilops amphidiploids, it was observed that some F 1 hybrids between Triticum ssp. and Aegilops were self-fertile, with seed set ranging from 0.97 to 39.72%. Seeds fertile 's spontaneous as determined by root-tip chromosome counts. The present study revealed autoduplication chromosomes in these caused tetraploid wheat parents T. persicum PS5 durum DR147. Detailed meiotic studies crossed Ae. squarrosa showed during meiosis, there two ways which unreduced...
Abstract β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented Aβ oligomers-induced inhibition long-term potentiation (LTP) at concentrations did not interfere with normal LTP. Bis(heptyl)-cognitin also synaptotoxicity primary hippocampal neurons. In contrast, tacrine and donepezil, typical AChE inhibitors,...