A5100674404- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Inflammasome and immune disorders
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Biological and pharmacological studies of plants
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Platelet Disorders and Treatments
- Visual Attention and Saliency Detection
- Immune Response and Inflammation
- Parallel Computing and Optimization Techniques
- Lipid metabolism and biosynthesis
- Treatment of Major Depression
- Cell Adhesion Molecules Research
- Neonatal and fetal brain pathology
- Hearing Loss and Rehabilitation
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Neuroendocrine regulation and behavior
- Cardiac, Anesthesia and Surgical Outcomes
Zunyi Medical University
2021-2024
Zhejiang University of Technology
2024
North Sichuan Medical University
2024
Nanchong Central Hospital
2024
Soochow University
2022
Ningbo No. 2 Hospital
2019
University of Southern California
2019
Ningxia Medical University
2017
Capital Medical University
2016
Beijing Children’s Hospital
2014-2016
Abstract Aims/introduction As a common complication in elderly patients after surgery/anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor, and intellectual retardation. Neuroinflammation one of the most uncontroversial views POCD. The sevoflurane-induced neurotoxicity has attracted widespread attention recent years. However, its mechanism not been determined. This study aimed to observe effects sevoflurane on function changes...
Depression is a common neuropsychiatric disorder and new anti-depressive treatments are still in urgent demand. Fast Green FCF, safe biocompatible color additive, has been suggested to mitigate chronic pain. However, green FCF's effect on depression unknown. We aimed investigate lipopolysaccharide (LPS)-induced depressive-like behavior the underlying mechanisms. Pretreatment of FCF (100 mg/kg, i.p. daily for 7 days) alleviated LPS-treated mice. suppressed LPS-induced microglial astrocyte...
Abstract Neuroinflammation is the main pathological mechanism of cognitive dysfunction caused by neurodegenerative diseases, and effective preventive therapeutic measures are not available. We predicted key targets gastrodin’s effects upon neuroinflammation through Network Pharmacology molecular docking. Then were used to study how gastrodin affected triggered lipopolysaccharide-induced in rats its mechanisms. Three-month-old male intraperitoneally injected with lipopolysaccharide for 3 days...
Objective To determine the incidence of congenital hearing loss (HL) in newborns by rate deafness-related genetic mutations. Design Clinical study consecutive Beijing using allele-specific polymerase chain reaction-based universal array. Study sample This tested 37 573 within 3 days after birth, including nine sites four genes: GJB2 (35 del G, 176 16, 235 C, 299 AT), SLC26A4 (IVS7-2 A > 2168 G), MTRNR1 (1555 1494 C T), and GJB3 (538 T). The birth condition infants was also recorded. Results...
Postoperative cognitive dysfunction (POCD) is a common clinical manifestation that severe complication characterized by decreased learning ability and deterioration of memory following anesthesia surgery. However, the precise mechanisms POCD are not completely understood. Rats were divided into blank control group (Con,
Abstract Postoperative cognitive dysfunction (POCD) is a common complication of decline after surgery and anesthesia. Sevoflurane, as commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), conserved splicing factor, has been reported exert important functions in multiple diseases’ progression. In this study, the effect NUDT21 on sevoflurane-induced POCD elucidated. Results showed that down-regulated hippocampal tissue rats. Morris water maze test results revealed...
Background Hypoxic‐ischemic encephalopathy (HIE) could induce exacerbated changes and unpredictable effects in brain cells, the mechanism remains unclear. Methods HIE model was established neonatal rats, Zea‐Longa score TTC staining were used to observe neurobehavior infarct volume rats subjected cerebral hypoxia‐ischemia (HI). Primary cortical neurons then cultured vitro establish an oxygen glucose deprivation model. To determine role of synaptosomal‐associated protein‐25 ( SNAP25 ) HIE,...
Abstract Objective To investigate the role of microRNA (miRNA)‐669f‐5p/deoxycytidylate deaminase (Dctd) axis in sevoflurane inducing cognitive dysfunction aged mice. Methods Sixty‐six C57BL/6J mice were used experiment model and randomly divided into group control group. The anesthetised with 3.4% sevoflurane, whereas those air‐treated for same period. study was then performed using bioinformatics sequencing, as well vitro vivo validation. Results showed significant impairments terms a...
High-quality printing is a longstanding objective in the and replication industry. However, methods used to evaluate print quality suffer from subjectivity multidimensionality, relying on personal preferences subjective perceptions assess of printed images, which poses significant limitations. To address these issues, set evaluation metrics aimed at assessing digital products proposed achieve results consistent with human visual perception. Given differing imaging principles pre-press images...
Background Chronic kidney disease (CKD) is a prevalent chronic condition that poses significant threat to human health. There close connection between the gut and kidneys, jointly influencing onset progression of CKD through “gut-kidney axis.” Traditional Chinese medicine has shown potential in treatment, but specific mechanisms require further investigation. Objectives This study aims explore protective effects Mizhuo Enema (MZGCY) on function rats by regulating TLR4/MyD88/NF-κB signaling...
To investigate the thrifty effects of subanesthetic-dose S-ketamine on postoperative opioids and its safety analgesic efficacy.
Abstract Aims/IntroductionAs a common complication in elderly patients after surgery / anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor and intellectual retardation. Neuroinflammation one of the most uncontroversial views POCD. The neurotoxicity caadopted sevoflurane has attracted wide attention recent years. However, its mechanism not been determined. aim this study was to observe effects on function changes inflammatory indices...
With the development of cloud computing, reliability disk arrays are increasingly concerned. Data centers usually use erasure codes to provide high reliability. However, most reconstruction methods on focus single/ multiple disk(s) recovery, which ignores how efficiently reconstruct lost data such as Latent Sector Errors (LSEs), etc. In real situations, local stripe errors much more common than failures. It has become an urgent problem that improve for stripes. This paper proposes a...
<h3></h3> Hearing loss is one of the commonest genetic disease which impact human health. There are about 60% hearing patient because facters. result overlapping factors predisposition and environmental impact. Mutations in mitochondrial 12S rRNA gene, particularly m.1555A >G have been repeatedly associated with increased susceptibility to ototoxic effect aminoglycoside antibiotics such as gentamycin, tobramycin, amikacin, kanamycin, or streptomycin. The Chinese government suggest...
Objective To study the role and mechanism of orexin A in cell viability Alzheimer’s disease (AD) model PC12. Methods PC12 cells were treated with 0, 10, 20, 30, 40 50 μmol/L Aβ25-35 for 24 h, then, was measured by MTT to confirm which concentration suitable one establish AD models. (1) models 0.01, 0.1, 1 2 30 added h; assay used determine conform A. (2) Inverted phase contrast microscope employed observe morphology changes PC12 from control group, treatment 0.01 A+30 group. (3) The...
Abstract Neuroinflammation is the main pathological mechanism of cognitive dysfunction caused by neurodegenerative diseases, and effective preventive therapeutic measures are not available. We predicted key targets gastrodin's effects upon neuroinflammation through Network Pharmacology molecular docking. Then were used to study how gastrodin affected triggered lipopolysaccharide-induced in rats its mechanisms. Three-month-old male intraperitoneally injected with lipopolysaccharide for 3 days...