A5027225240- Pain Mechanisms and Treatments
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuropeptides and Animal Physiology
- Cancer Treatment and Pharmacology
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Myasthenia Gravis and Thymoma
- Organ and Tissue Transplantation Research
- Hematopoietic Stem Cell Transplantation
- Anesthesia and Sedative Agents
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
- Urinary Bladder and Prostate Research
- Anesthesia and Neurotoxicity Research
- Neuroblastoma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Polyomavirus and related diseases
- Cholinesterase and Neurodegenerative Diseases
- Medical Imaging and Pathology Studies
Ningbo University
2014-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
China International Science and Technology Cooperation
2025
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
University of Pittsburgh
2008-2023
First Hospital of Jilin University
2021-2023
Jilin University
2021-2023
Tianjin Agricultural University
2023
Journal Article Smoking-Related Weight Concerns and Obesity: Differences Among Normal Weight, Overweight, Obese Smokers Using a Telephone Tobacco Quitline Get access Michele D. Levine, PhD, PhD 1Department of Psychiatry, University Pittsburgh Medical Center, Pittsburgh, PA; Search for other works by this author on: Oxford Academic PubMed Google Scholar Terry Bush, 2Alere, Clinical Behavioral Sciences, Seattle, WA; Brooke Magnusson, MA, MA Yu Cheng, 3Department Statistics, PA Xiaotian Chen,...
Hepatocellular carcinoma (HCC) is a predominant cause of cancer-related mortality globally, noted for its propensity towards late-stage diagnosis and scarcity effective treatment modalities. The process metabolic reprogramming, with specific emphasis on lipid metabolism, instrumental in the progression HCC. Nevertheless, precise mechanisms through which metabolism impacts HCC viability as therapeutic target have yet to be fully elucidated. In current investigation, single-cell RNA sequencing...
Fragile X mental retardation protein (FMRP) has been proposed to play a potential role in the pathogenesis of autonomy and nociceptive paresthesia. However, involvement spinal FMRP neuropathic pain remains unexplored. Using rat model induced by chronic constriction injury (CCI), our investigation demonstrated an upregulation at 3, 7, 14 days post-CCI operation dorsal horn (SDH). Immunofluorescence staining revealed predominant expression neurons, which colocalized with Glutamate Ionotropic...
Neuropathic pain, a debilitating nerve injury-induced condition, remains significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in spared injury (SNI) mouse model. Systemic administration selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain mice both sexes. increased acetylated signal transducer and activator transcription 3 (Ac-STAT3) reduced phosphorylated STAT3 (p-STAT3) lumbar spinal cord SNI mice....
Depression is a common neuropsychiatric disorder and new anti-depressive treatments are still in urgent demand. Fast Green FCF, safe biocompatible color additive, has been suggested to mitigate chronic pain. However, green FCF's effect on depression unknown. We aimed investigate lipopolysaccharide (LPS)-induced depressive-like behavior the underlying mechanisms. Pretreatment of FCF (100 mg/kg, i.p. daily for 7 days) alleviated LPS-treated mice. suppressed LPS-induced microglial astrocyte...
Chemotherapy-induced peripheral neuropathy (CIPN) commonly causes neuropathic pain, but its pathogenesis remains unclear, and effective therapies are lacking. Naringenin, a natural dihydroflavonoid compound, has anti-inflammatory, anti-nociceptive anti-tumour activities. However, the effects of naringenin on chemotherapy-induced pain chemotherapy effectiveness remain unexplored.
Sensitization of bladder afferents is an underlying contributor to the development and maintenance painful syndrome/interstitial cystitis. Extracellular purines pyrimidines (e.g., ATP UTP), released during distension or from damaged cells after tissue insult, are thought play important role in physiological pathological states by actions at ionotropic P2X metabotropic P2Y receptors. In present study, we examined ability receptors sensitize modulate P2X-mediated responses mouse sensory...
Fast Green FCF (FGF), a biocompatible dye, recently drew attention as potential drug to treat amyloid-deposit diseases due its effects against amyloid fibrillogenesis in vitro and high degree of safety. However, role inflammatory pain is unknown. Our study aimed investigate the effect FGF model induced by complete Freund's adjuvant (CFA) identify associated mechanisms. We found that systemic administration reversed mechanical thermal hypersensitivity evoked CFA dose-dependent manner....
Bisphenol-A (BPA), a widely used synthetic compound in plastics, disrupts endocrine function and interferes with physiological actions of endogenous gonadal hormones. Chronic effects BPA on reproductive function, learning memory, brain structure, social behavior have been intensively investigated. However, less is known about the influence long-term potentiation (LTP), one major cellular mechanisms that underlie memory. In present study, for first time we investigated effect different doses...