A5101898089- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Thermoregulation and physiological responses
- Retinal Diseases and Treatments
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Autophagy in Disease and Therapy
- Nausea and vomiting management
- Pain Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Enhanced Recovery After Surgery
- Gastric Cancer Management and Outcomes
- Neuroendocrine regulation and behavior
- Global Health and Surgery
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Asthma and respiratory diseases
- Ginkgo biloba and Cashew Applications
- Natural Compounds in Disease Treatment
- Erythrocyte Function and Pathophysiology
- Plant Toxicity and Pharmacological Properties
Ningbo No. 2 Hospital
2015-2025
University of Chinese Academy of Sciences
2019-2025
Affiliated Hospital of Southwest Medical University
2024
Shanghai Institute of Pharmaceutical Industry
2023
Zunyi Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Mount Sinai Hospital
2019
Henan University of Science and Technology
2017
University of Oklahoma Health Sciences Center
2012-2016
St. Luke's-Roosevelt Hospital Center
2012-2014
<h3>Importance</h3> In adults undergoing hip fracture surgery, regional anesthesia may reduce postoperative delirium, but there is uncertainty about its effectiveness. <h3>Objective</h3> To investigate, in older surgical repair for fracture, the effects of on incidence delirium compared with general anesthesia. <h3>Design, Setting, and Participants</h3> A randomized, allocation-concealed, open-label, multicenter clinical trial 950 patients, aged 65 years older, or without preexisting...
Summary Introduction Data regarding the incidence of 12‐month postoperative cognitive decline following regional or general anaesthesia in older patients undergoing hip fracture surgery remain observational. Compared with anaesthesia, we hypothesised that would decrease decline. Methods This is substudy a multicentre randomised trial no sedation vs. follow‐up, conducted nine university hospitals south‐eastern China. Patients aged ≥ 65 y fractures requiring were eligible for inclusion. The...
Inadvertent intraoperative hypothermia (core temperature <36°C) is a frequently preventable complication with several adverse consequences. Our study aimed to determine the overall incidence of inadvertent and its risk factors associated clinical outcomes in this national survey China.We conducted cross-sectional 30 days postoperative follow-up from November 2014 through August 2015. A total 3132 eligible patients underwent general anesthesia were randomly selected 28 hospitals nationwide...
Intra-retinal extravasation and modification of LDL have been implicated in diabetic retinopathy: autophagy may mediate these effects.Immunohistochemistry was used to detect marker LC3B human murine non-diabetic retinas. Cultured retinal capillary pericytes (HRCPs) were treated with vitro-modified heavily-oxidised glycated (HOG-LDL) vs native (N-LDL) or without modulators: green fluorescent protein-LC3 transfection; small interfering RNAs against Beclin-1, c-Jun NH(2)-terminal kinase (JNK)...
Neuropathic pain, a debilitating nerve injury-induced condition, remains significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in spared injury (SNI) mouse model. Systemic administration selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain mice both sexes. increased acetylated signal transducer and activator transcription 3 (Ac-STAT3) reduced phosphorylated STAT3 (p-STAT3) lumbar spinal cord SNI mice....
Recently it has been shown that levels of circulating oxidized LDL immune complexes (ox-LDL-ICs) predict the development diabetic retinopathy (DR). This study aimed to investigate whether ox-LDL-ICs are actually present in retina, and define their effects on human retinal pericytes versus ox-LDL. In sections from people with type 2 diabetes, costaining for ox-LDL IgG was present, proportionate DR severity, detectable even absence clinical DR. contrast, no such staining observed retinas...
Abstract Background A high prevalence of postoperative complications is closely associated with a worse short- and long-term outcome. This current study aimed to investigate potential risk factors including albumin-to-fibrinogen ratio (AFR) for severe (SPCs) in surgical gastric cancer (GC) patients. Methods Elderly patients (≥65 years) primary GC who underwent elective radical laparoscopic gastrectomy under general anesthesia were included. According the Clavien–Dindo classification system,...
BACKGROUND The aim of this study was to examine the association between serum expression miRNA-155 and postoperative cognitive dysfunction (POCD) after laparoscopic surgery for colon cancer. MATERIAL AND METHODS We enrolled 110 patients scheduled undergo tumor resection via laparotomy in Ningbo No. 2 Hospital from July 2013 November 2015. blood samples were collected participants 1 day before surgery. Multiple logistic regression analysis used independent predictive biomarkers POCD. RESULTS...
Inadvertent intraoperative hypothermia (core temperature <36 °C) is a frequent but preventable complication of general anesthesia. Accurate risk assessment individual patients may help physicians identify at for and apply preventive approaches, which include active warming. This study aimed to develop validate risk-prediction model hypothermia. Two independent observational studies in China, the Beijing Regional Survey China National Survey, were conducted 2013 2014, respectively, determine...
Background: Delirium is commonly observed among elderly surgical subjects during the postoperative period, and incidence of delirium (POD) in patients (≥65 years) ranges widely from 10% to 70%. This study aimed at investigating potential serum predicative factors for POD after open abdominal surgery. Keywords: Postoperative delirium, surgery, risk factors, insulin-like growth factor-1.
Fast Green FCF (FGF), a biocompatible dye, recently drew attention as potential drug to treat amyloid-deposit diseases due its effects against amyloid fibrillogenesis in vitro and high degree of safety. However, role inflammatory pain is unknown. Our study aimed investigate the effect FGF model induced by complete Freund's adjuvant (CFA) identify associated mechanisms. We found that systemic administration reversed mechanical thermal hypersensitivity evoked CFA dose-dependent manner....
Postoperative delirium (POD), a neurobehavioral syndrome induced by dysfunction of neural activity, is common and serious complication. This current study aimed to investigate independent predictors for POD in elderly subjects after total joint arthroplasty (TJA).Eligible patients (≥65 years) who underwent elective unilateral primary hip or knee under epidural anesthesia from October 2016 January 2019 were consecutively enrolled. was diagnosed following the guidance 5th edition Diagnostic...
Postoperative delirium (POD) is an acute form of brain dysfunction that can result in serious adverse consequences. There has been a link between cognitive and poor sleep. The present study aimed to determine the association prediction subjective sleep quality postoperative during major non-cardiac surgery.One hundred thirty-four patients, aged 60 years or older, were scheduled for elective laparotomy orthopaedic procedures. Pittsburgh Sleep Quality Index (PSQI) log used assess perioperative...
The study aimed to assess whether preoperative resting heart rate could be a risk factor for cardiopulmonary complications (CPCs) after lung cancer resection. Eligible consecutive patients who underwent resection surgery non-small cell (NSCLC) at Ningbo NO.2 Hospital between May, 2010 and July, 2015 were included. demographic, clinical characteristics laboratory parameters compared in with or without CPCs within postoperative 30 days. multivariate logistic regression analysis was used...
To explore the effect of nursing intervention and quality feedback guided by stress system theory on neurological function recovery post-traumatic growth in patients with cerebral hemorrhage.
Postoperative Pulmonary Complications (PPCs) can contribute to increased mortality and prolonged hospital stay in surgical patients with Gastric Cancer (GC). This study aimed investigate potential risk factors for PPCs elderly GC following elective laparoscopic gastrectomy.Eligible consecutive (aged over 65 years) who were scheduled undergo gastrectomy enrolled this study. The demographic, clinicopathological characteristics laboratory variables compared or without within postoperative 30...
Background: Postoperative delirium (POD) is a very common complication in elderly patients with gastric cancer (GC) and associated poor prognosis. MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression via targeting mRNAs play important roles the nervous system. This study aimed to investigate potential predictive role miRNAs for POD. Methods: Elderly GC who were scheduled undergo elective curative resection consequently enrolled this study. POD was assessed at 1...
Gnaphalium affine is traditionally used to treat hyperuricemia and gout in China. Recently, the hypouricemic renal protective effects of G. extract (GAD) have been deeply evaluated. However, little known about pharmacokinetics (PKs) bioactive constituents GAD. This study aimed at investigating individual holistic 10 components (including caffeic acid, caffeoylquinic acids, flavonoids) rats after single multiple administrations GAD orally dosed normal male doses 225, 450, or 900 mg/kg/day for...
Neonatal hyperbilirubinemia (jaundice) is a common disease with high incidence. Currently, hemoperfusion (blood exchange transfusion) always used for the treatment of severe hyperbilirubinemia. However, there are several limitations blood transfusion, such as lack safe supply and transfusion complications, while main problem hemoperfusions inefficient performance current bilirubin absorbent, which makes it impossible to administer neonatal cases. Identification adsorbent overall excellent...