A5085204828- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemodynamic Monitoring and Therapy
- Enhanced Recovery After Surgery
- Nausea and vomiting management
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Pelvic and Acetabular Injuries
- Congenital Heart Disease Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Mechanisms and Treatments
- Scoliosis diagnosis and treatment
- Global Cancer Incidence and Screening
- Traumatic Brain Injury and Neurovascular Disturbances
- Colorectal Cancer Screening and Detection
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Circadian rhythm and melatonin
- Cancer Treatment and Pharmacology
- Mechanical Circulatory Support Devices
- Mitochondrial Function and Pathology
Nanjing Drum Tower Hospital
2016-2025
Xijing University
2025
Nanjing University
2015-2025
Nanjing Medical University
2015-2023
Nanjing Brain Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Andalusian School of Public Health
2022
Peking Union Medical College Hospital
2022
Shanghai Skin Disease Hospital
2022
Tongji University
2022
From 2003 to 2005, standardised 5-year cancer survival in China was much lower than developed countries and varied substantially by geographical area. Monitoring population-level is crucial the understanding of overall effectiveness care. We therefore aimed investigate statistics for people with between 2015.
Limited population‐based cancer registry data available in China until now has hampered efforts to inform control policy. Following extensive improve the systematic surveillance this country, we report on largest pooled analysis of survival date. Of 21 registries, from 17 registries ( n = 138,852 records) were included final analysis. Cases diagnosed 2003–2005 and followed end 2010. Age‐standardized relative was calculated using region‐specific life tables for all cancers combined 26...
Inadvertent intraoperative hypothermia (core temperature <36°C) is a frequently preventable complication with several adverse consequences. Our study aimed to determine the overall incidence of inadvertent and its risk factors associated clinical outcomes in this national survey China.We conducted cross-sectional 30 days postoperative follow-up from November 2014 through August 2015. A total 3132 eligible patients underwent general anesthesia were randomly selected 28 hospitals nationwide...
Neuroinflammation following peripheral surgery is a pivotal pathogenic mechanism of postoperative cognitive dysfunction (POCD). However, the key site inflammation-mediated neural damage remains unclear. Impaired mitochondrial function vital feature degenerated neurons. Dynamin-related protein 1 (DRP1), crucial regulator dynamics, has been shown to play an essential role in synapse formation. Here, we designed experiments assess whether Drp1-regulated dynamics and are involved pathological...
Postoperative cognitive dysfunction (POCD) is a common postoperative complication involving the central nervous system, but underlying mechanism not well understood. Neuroinflammation secondary to surgery and anesthesia strongly correlated with POCD. A key aspect of neuroinflammation microglia activation. Triggering receptor expressed on myeloid cells (TREM)2, which highly in microglia, an innate immune that modulates function. In this study we investigated role TREM2 impairment...
Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity induces impairments, but the exact mechanism remains unclear. Astrocytes form interconnected networks in adult brain through gap junctions (GJs), which primarily comprise connexin 43 (Cx43), play important roles homeostasis functions such as memory. However, role of GJ-Cx43-mediated astrocytic network isoflurane-induced not been...
Video-assisted thoracoscopic surgery (VATS) has been widely used as an alternative for thoracotomy, but the reported incidence of chronic postsurgical pain (CPSP) following VATS varied widely. The purpose this study was to investigate and risk factors CPSP after VATS.We retrospectively collected preoperative demographic, anesthesiology, surgical in a cohort patients undergoing between January 2018 October 2020. Patients were interviewed via phone survey intensity, related medical treatment 3...
Excess polymorphonuclear neutrophil (PMN) recruitment or excessive extracellular trap (NET) formation can lead to the development of multiple organ dysfunction during sepsis. M2 macrophage-derived exosomes (M2-Exos) have exhibited anti-inflammatory activities in some inflammatory diseases mediate functional protection, but their role treating sepsis-related acute lung injury (ALI) remains unclear. In this study, we sought investigate whether M2-Exos could prevent potentially deleterious...
Objective To determine the association between preoperative Bioenergetic Health Index (BHI) of platelets and occurrence postoperative delirium (POD) in elderly patients. Methods Elderly patients scheduled for major abdominal surgery under general anesthesia were included. The presence POD was assessed within 3 days after surgery. Seahorse XF analysis transmission electron microscopy utilized to evaluate mitochondrial metabolism morphology platelets. Results A total 20 out 162 participants...
Abstract Background Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits sepsis-associated encephalopathy (SAE), yet underlying mechanisms remain largely unclear. Dynamin-related protein 1 (Drp1) facilitates mitochondrial fission and ensures quality control to maintain cellular homeostasis during infection. This study aimed investigate potential role GSDMD/Drp1 signaling pathway impairments a mouse model SAE. Methods C57BL/6 male mice...
Background —Repair of muscular ventricular septal defects (MVSDs) has always been challenging to the surgeon. Long-term morbidity and mortality are significantly increased if closed via left ventriculotomy or they associated with other complex congenital anomalies. The purpose this study was close MVSDs Amplatz defect device. This device is constructed from 0.004-in nitinol wire mesh filled polyester fibers. It retrievable, repositionable, self-centering, low profile. Methods Results —MVSDs...
Astaxanthin (ATX) is a powerful antioxidant that occurs naturally in wide variety of living organisms. Previous studies have shown ATX has effects eliminating oxygen free radicals and can protect organs from ischemia/reperfusion (IR) induced injury. The present study was designed to further investigate the protective on oxidative stress toxicity tubular epithelial cells IR renal injury mice. ATX, at concentration 250 nM, attenuated 100 μM H2O2-inudced viability decrease cells. In vivo,...
Cancer is a major public health burden both globally and in China. The most common cancer-related deaths China are attributable to cancers of the lung, liver, stomach, esophagus. Previous epidemiologic studies on cancer have often been limited by small sample sizes, inconsistent measurements, lack precise accurate data. Jiangsu Four Cancers (JFC) Study population-based case–control study carried out an effort obtain consistent high-quality data investigate life style, behavioral,...
The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess inflammatory immune activities in hippocampus involved progression both pain. Considering microglia are substrates initiation propagation neuroimmune response, we hypothesized stress-induced activation hippocampal may contribute to pathogenesis disorder-pain comorbidity. We showed rats exposed single...
Perioperative neurocognitive disorders (PND) refer to cognitive deterioration that occurs after surgery or anesthesia. Prolonged isoflurane exposure has potential neurotoxicity and induces PND, but the mechanism is unclear. The glymphatic system clears harmful metabolic waste from brain. This study sought unveil functions of in PND explore underlying molecular mechanisms. mice model was established by long term function assessed multiple vitro vivo methods. An adeno-associated virus used...
Postoperative cognitive dysfunction is a severe complication of the central nervous system that occurs after anesthesia and surgery, has received attention for its high incidence effect on quality life patients. To date, there are no viable treatment options postoperative dysfunction. The identification hub genes could provide new research directions therapeutic targets future research. identify signaling mechanisms contributing to dysfunction, we first conducted Gene Ontology Kyoto...
Cognitive impairment is a common issue among human patients undergoing surgery, yet the neural mechanism causing this remains unidentified. Surgical procedures often lead to glial cell activation and neuronal hypoexcitability, both of which are known contribute postoperative cognitive dysfunction (POCD). However, role neuron-glia crosstalk in pathology POCD still unclear. Through integrated transcriptomics proteomics analyses, we found that complement cascades microglial phagocytotic...
To explore risk factors for 1-year postoperative mortality and to identify its association with the Revised Cardiac Risk Index (RCRI). This was a retrospective cohort study involving 54,933 patients aged 18 years above who were surgically treated under general or regional anesthesia in tertiary hospital Singapore. Independent identified by univariate Cox regression analysis. The between RCRI assessed Kaplan-Meier estimator multivariate analysis further validated subgroup analyses stratified...
Rationale: Internal modifications of mammalian RNA have been suggested to be essential for the maintenance cardiac homeostasis. However, role cytosine methylation (m5C) in heart remains largely unknown. Methods: Bulk and single cell sequencing data tissues from human hearts were exploited analyzing expression m5C modifying proteins. Neonatal rat adult mouse cardiomyocytes isolated assess impact Nsun2 on cellular hypertrophic response. Cre/LoxP-mediated gene knockout recombinant...