A5101506025- Bone Metabolism and Diseases
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Sepsis Diagnosis and Treatment
- Muscle Physiology and Disorders
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Amyotrophic Lateral Sclerosis Research
- IL-33, ST2, and ILC Pathways
- Inflammation biomarkers and pathways
Anhui University of Traditional Chinese Medicine
2025
Nanjing University
2013-2024
Chengdu University of Traditional Chinese Medicine
2024
GTx (United States)
2023
First Affiliated Hospital of Zhengzhou University
2023
Henan University
2023
Anhui Medical University
2021-2022
ShenZhen People’s Hospital
2022
Jiangsu Cancer Hospital
2018-2022
Zhongshan Hospital
2022
Sepsis-associated encephalopathy (SAE) is a common complication that leads to long-term cognitive impairments and increased mortality in sepsis survivors. The mechanisms underlying this remain unclear an effective intervention lacking. Accumulating evidence suggests the nucleotide-binding domain-like receptor protein3 (NLRP3)/caspase-1 pathway involved several neurodegenerative diseases. Thus, we hypothesized NLRP3/caspase-1 NLRP3-mediated pyroptosis, maturation release of inflammatory...
Abstract Background Gasdermin D (GSDMD)-mediated pyroptotic cell death is implicated in the pathogenesis of cognitive deficits sepsis-associated encephalopathy (SAE), yet underlying mechanisms remain largely unclear. Dynamin-related protein 1 (Drp1) facilitates mitochondrial fission and ensures quality control to maintain cellular homeostasis during infection. This study aimed investigate potential role GSDMD/Drp1 signaling pathway impairments a mouse model SAE. Methods C57BL/6 male mice...
ABSTRACT Piwei Peiyuan (PWPY) prescription is a traditional Chinese medicine and has been efficiently used in the clinics to treat chronic atrophic gastritis (CAG) for many years. However, mechanism of action underlying PWPY treating CAG remains elusive. A rat animal cell model was constructed this study explore CAG. Here we show that attenuates progression by eliciting MAPK10‐mediated mitochondrial autophagy. Experimental introduced using N ‐methyl‐n'‐nitro‐n‐nitroguanidine (MNNG). Our...
As the only cell capable of bone resorption, osteoclast is a central mediator skeletal homeostasis and disease. To efficiently degrade mineralized tissue, these multinucleated giant cells secrete acid into resorption lacuna formed between their apical membrane surface. For each proton pumped this extracellular compartment, one bicarbonate ion remains in cytoplasm. prevent alkalinization cytoplasm, basolateral bicarbonate/chloride exchanger provides egress for intracellular bicarbonate....
Studies have shown that the abnormal activation of NLRP3 inflammasome is involved in a variety inflammatory-based diseases. In this study, high content screening model targeting was first established and pterostilbene discovered as active scaffold. Based on finding, total 50 derivatives were then designed synthesized. Among them, compound 47 found to be best one for inhibiting cell pyroptosis [inhibitory rate (IR) = 73.09% at 10 μM], showing low toxicity efficiency [against interleukin-1β...
Aim: Circular RNAs are widely and abnormally expressed in human cancer cells, they participate progression. However, have rarely been investigated the immune evasion of non-small cell lung (NSCLC). Here, we elucidated function molecular mechanism hsa_circ_0020714 promoting resistance to anti-PD-1 immunotherapy NSCLC. Methods: The expression were examined by qRT-PCR. In vivo experiments executed investigate biological sensitivity NSCLC immunotherapy. qRT-PCR, fluorescence situ hybridization,...
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with poor prognosis limited treatment options. The incidence of IPF increases age, the mechanisms related to aging such as cellular senescence have been strongly implicated in pathology. Therefore, better understanding fibroblasts might provide new therapeutic strategy prevent treat fibrosis. In this study, we aimed explore effects citrus alkaline extracts (CAE) on senescence, elucidate underlying...
The blood-brain barrier (BBB) continues to be one of the main clinical obstacles in treatment glioma. Current chemotherapies always bring many different side effects, some even permanent. To date, nanomaterial-based vehicles have shown great potential treating Herein, we developed a dual targeting liposomal delivery vector loaded with anticancer drug doxorubicin (DOX) treat SS31, small peptide, has effects penetrating BBB and specifically mitochondria. In this study, new system, LS-DOX, was...
Pyroptosis is a recently characterized inflammatory form of programmed cell death that thought to be involved in the pathogenesis perioperative neurocognitive disorders (PND). Elamipretide (SS-31), mitochondrial-targeted peptide with multiple pharmacological properties, including anti-inflammatory activity, has been demonstrated protect against many neurological diseases. However, effect elamipretide on pyroptosis PND not studied. We established an animal model by performing exploratory...
Malic acid, in the form of its anion malate, is a key intermediate major biochemical energy-producing cycle known as citric acid or Krebs cycle. In this study, authors investigated protective effect novel crystalloid solution Ringer’s malate following fluid resuscitation hemorrhagic shock using rat model. Under general anesthesia, Sprague-Dawley male rats were subjected to 60 min (40 mmHg for min) followed by resuscitation. Groups follows: (1) sham shock, (2) normal saline, (3) lactate, and...
Labeling of a small bioactive molecule with fluorescent probe has been becoming an essential tool in cell biology to reveal the subcellular distribution and location molecular target. QOA-8a is novel potent antiosteoporotic effect vivo. To investigate mechanism QOA-8a, fluorescence-tagged chemical probes as their parent were designed synthesized. The compound 12 showed more inhibitory activity on RANKL-induced osteoclastogenesis at 2 μM compared that QOA-8a. Microscopy experiments revealed...
Cucurbitacin B (CuB), a highly cytotoxic constituent of the Cucurbitaceae plant, was identified to exhibit potent inhibitory activity against human cancer cells as well normal cells. This disadvantage hampers possibility developing this compound into an anticancer drug candidate. In work, several bioreductive prodrugs CuB were designed reduce toxicity while maintaining effect Embedded with delivery and cleavable system in tissues, cucurbitacin B-based 1, 2, 3 synthesized evaluated by vitro...