A5109304535- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Inflammatory Biomarkers in Disease Prognosis
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Anesthesia and Pain Management
- Antibiotic Resistance in Bacteria
- Heme Oxygenase-1 and Carbon Monoxide
- Angiogenesis and VEGF in Cancer
- Antibiotic Use and Resistance
- Sodium Intake and Health
- interferon and immune responses
- Biosensors and Analytical Detection
- Neurogenesis and neuroplasticity mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Vagus Nerve Stimulation Research
- Hepatitis B Virus Studies
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Medicinal Plant Pharmacodynamics Research
- Hepatitis C virus research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Hebei Medical University
2024
Northwest Institute of Eco-Environment and Resources
2024
Chinese Academy of Sciences
2024
Third Hospital of Hebei Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
Nanjing Drum Tower Hospital
2009-2021
Weatherford College
2021
People's Liberation Army 401 Hospital
2021
Hebei University of Chinese Medicine
2021
Xiangya Hospital Central South University
2019
The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess inflammatory immune activities in hippocampus involved progression both pain. Considering microglia are substrates initiation propagation neuroimmune response, we hypothesized stress-induced activation hippocampal may contribute to pathogenesis disorder-pain comorbidity. We showed rats exposed single...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Prolonged endoplasmic reticulum stress has been identified in various diseases. Inflammatory mediators, which have shown to induce several studies, suggested serve as the important modulators pain development. In this study, authors hypothesized that triggered by inflammatory mediators contributed Methods The used a male mouse model of bone cancer pain. control mice were intrathecally...
The V0 interneuronal population is derived from Dbx1 expressing progenitors. Initial studies on these interneurons in the mouse spinal cord demonstrated that they project commissural axons and are involved coordinating left-right alternation during locomotion. Subsequent work has indicated can be divided into genetically distinct ventral (V0V) dorsal (V0D) subpopulations, experimental evidence suggests each responsible for at different locomotor speeds. In this study, we perform a series of...
Pseudomonas aeruginosa is emerging as a highly multidrug-resistant (MDR) nosocomial pathogen. Data on the efficacy of infection control measures in endemic situations are lacking. We investigated effect antimicrobial stewardship (AMS) and programs (ICPs) controlling resistance P. at tertiary hospital center.Susceptibility were using broth microdilution, per guidelines Clinical Laboratory Standards Institute. Antibiotic use was restricted through AMS, which included classification management...
Spinal N-methyl D-aspartate receptors play an important role in the pathogenesis of neuropathic pain, and administration receptor antagonists can attenuate this hyperpathia. Ifenprodil is antagonist selective for 2B (NR2B) subunits. Several researches have reported effective analgesia ifenprodil animal models pain. We extended work to include chronic compression dorsal root ganglia (CCD).The paw withdrawal mechanical threshold thermal latency tests were used assess allodynia hyperalgesia...
Background Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate pronociceptive systems and enhance postoperative pain. Glial cells are thought to be implicated remifentanil-induced hyperalgesia. Electroacupuncture is a complementary therapy relieve various pain conditions with few side effects, glial may involved its antinociceptive effect. In this study, we investigated whether intraoperative electroacupuncture could...
Borosins are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with α-N-methylated backbones. Although the first mature compound borosin was reported in 1997, biosynthetic pathway elucidated 20 years later. Until this work, borosins have been able to be categorized into 11 types based on features their protein structure core peptides. Type III were only fungi initially. In order explore sources potential type borosins, precise genome mining work conducted...
Aims: To explore the distribution of site‐specific volumetric bone mineral density (vBMD) and analyze mechanism vertebral compression fractures with type 2 diabetes mellitus (T2DM) subjects using quantitative computed tomography (QCT). Materials Methods: 304 postmenopausal women without T2DM 274 underwent QCT scan, all divided into three age subgroups. L1 vertebra was segmented nine zones based on corresponding position to human body. Results: Whether in or non‐T2DM each group, from ventral...
In Brief BACKGROUND: The fact that transient receptor potential ankyrin 1 (TRPA1) on the peripheral terminals could attenuate hyperalgesia is widely accepted, but effect of spinal TRPA1 in modulation has not been fully demonstrated. present study, we investigated intrathecal (i.t.) administration antagonists chronic pain and expression phosphorylation N-methyl-D-aspartate 2B subunit (p-NR2B) cord with compression dorsal root ganglia (CCD) rats. METHODS: study was conducted 2 parts. Part 1:...
To investigate the applicability of astragaloside IV (AG) for treatment refractory neuropathic pain, we systemically evaluated antinociceptive activity AG in animal model chronic constriction injury. We studied behaviors, electrophysiology, and biochemistry from day 2 to 23 after surgery. found that when administered intraperitoneally at dose 60 mg/kg, caused significant inhibition allodynia hyperalgesia induced by mechanic thermal stimuli as well downregulation expressions a series proteins...
Patients with prostate cancer (PCa) will eventually progress to castrate-resistant (CRPC) after androgen deprivation therapy (ADT) treatment. Prostate-specific antigen (PSA)−/lo cells which harbor self-renewing long-term tumor-propagating that can be enriched using ALDH+CD44+α2β1+ and initiate tumor development may represent a critical source of CRPC cells. Our purpose was find peptide specifically targets PSA−/lo PCa retard the CRPC. PSA+ were successfully separated from LNCaP xenograft...
Purpose: To investigate the ameliorative effect of daidzin (DZ) on diabetes in streptozotocin (STZ)- induced diabetic Institute Cancer Research (ICR) mice, with a view to determining its usefulness treatment diabetes.Methods: The DZ (100, 200 and 400 mg/kg) blood glucose was investigated both normal STZ-induced mice glibenclamide (3 metformin (400 as positive control, respectively. Serum or hepatic levels lipid, proinflammatory factors, malondialdehyde (MDA) superoxide dismutase (SOD) were...
Abstract The visualization of intrahepatic hepatitis B virus (HBV) DNA by in situ hybridization (ISH) has uncovered some interesting aspects HBV life cycle at the single-cell level. In current study, we intend to evaluate reliability and robustness this assay real-world clinical scenario its relationship with currently available biomarkers chronic (CHB) patients. cross-sectional 94 CHB patients 10 non-HBV related liver diseases were enrolled. Liver biopsies routine histopathology analysis...
This study aimed to investigate the alteration of circulating CD34+KDR+CD133+ endothelial progenitor cells (EPCs) in patients with newly diagnosed type 2 diabetes and mechanism effect early intensive insulin therapy. In this study, 36 22 control subjects matched by age gender were enrolled. All received The number EPCs was assessed flow cytometry based on expression CD34, CD133, kinase insert domain-containing receptor (KDR). Levels higher compared significantly decreased after vascular...
Objective To analyze the antibiotic resistance of Branhemella catarrhalis strains isolated from sputum specimens patients with lower respiratory tract infections Linyi, Shandong Province, and to explore relationship between bro genotypes their agents. Methods Sputum were colleted in Linyi People's Hospital January 2010 December 2014. The inoculated into 4 different disks for bacterial isolation cultivation. β- lactamase detection drug sensitivity tests performed, PCR coupled...
To investigate the effects of anti-androgen drugs and melengestrol acetate (MGA) on development regrowth antlers in 6 year old sika deer, twenty healthysika deerwith similar body weight antler weightwere randomly divided into five groups by using single factor test design: flutamide (n=4), bicalutamide progesterone (CPA, n=4), (MGA, control(n=4). All deer were fed with same diets housed outside together an opened fence 15 m×30 m free access to water feed. Treatment injected subcutaneously...