A5100679329- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Anesthesia and Pain Management
- Thermal Regulation in Medicine
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects of Natural Compounds
- Infrared Thermography in Medicine
- Neuroscience and Neuropharmacology Research
- Ultrasound in Clinical Applications
- Bladder and Urothelial Cancer Treatments
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Sepsis Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Moyamoya disease diagnosis and treatment
- Medicinal Plants and Neuroprotection
- Dietary Effects on Health
- Spinal Cord Injury Research
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Health and Risk Factors
Nanjing Drum Tower Hospital
2015-2025
Shenyang Aerospace University
2024
Nanjing Medical University
2022
China Pharmaceutical University
2022
Zero to Three
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Fu Wai Hospital
2015
State Key Laboratory of Cardiovascular Disease
2015
Renji Hospital
2014
Shanghai Jiao Tong University
2014
The new-onset cerebral infarction is frequent after revascularization of moyamoya disease (MMD) in adults, serving as a major public health issue worldwide. present study aims to construct nomogram predict postoperative (POCI) adult MMD. Clinical data 653 cases MMD treated with were retrospectively analyzed. They randomly divided into training set (n = 457) and validation 196) at ratio 7:3. Based on the risk factors POCI identified by logistic regression analysis corresponding coefficients,...
Background The root of Polygala tenuifolia, a traditional Chinese medicine, has been used to improve memory and intelligence, while the underlying mechanisms remain largely unknown. In this study, we investigated protective effects senegenin, an component tenuifolia extracts, on cognitive dysfunction induced by hepatic ischemia-reperfusion. Methodology/Principal Findings Initially, constructed rat model ischemia-reperfusion (HIR) found that retention ability rats in step-down Y maze test was...
Background Microglia might play an important role in nociceptive processing and hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on microglia a central the modulation of activity. However roles MR radicular pain were not well understood. This study sought to investigate whether selective antagonist spironolactone develop antinociceptive effects inhibition neuroinflammation induced spinal activation. Results Radicular was produced chronic compression dorsal...
Spinal nitric oxide is involved in the mechanisms of pain generation and transmission during inflammatory neuropathic pain. The aim present study was to explore role spinal development bone cancer 2x105 osteosarcoma cells were implanted into intramedullary space right femurs C3H/HeJ mice induce a model ongoing cancer. Polymerase chain reaction immunohistochemical analyses performed assess expression neuronal synthase (nNOS) inducible (i)NOS cord following inoculation. results showed that...
Background: Currently, the role of melatonin (MT) in neuronal damage remains unclear and this study aimed to explore protective effects MT on neurons an <i>in vitro</i> cell injury model. Methods: The Sprague Dawley (SD) rat traumatic brain (TBI) model was prepared, tissue extract (BTE) from injured area were generated. To establish a vitro</i>, BTE added culture medium during neuron process. introduced into observe its neurons. Relevant molecular biology experiments conducted cellular...
Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or pelvis. However, underlying mechanisms of bone remain largely unknown. The present study aimed determine role tumor necrosis factor-α (TNF-α) development pain. Osteosarcoma NCTC 2472 cells were implanted into femoral intramedullary space C3H/HeJ mice establish a model. Resulting pain-related behaviors, namely spontaneous foot lifting, paw withdrawal...
Preoperative anxiety is associated with postoperative hyperalgesia; however, few studies have investigated the mechanism underlying this association in female surgical patients. Research has suggested that ON cells rostral ventromedial medulla (RVM) receive nerve impulses via cholecystokinin 2 (CCK2) receptors, facilitating hyperalgesia. Additionally, downstream serotonergic projection system from RVM to spinal cord a dual regulating effect on pain responses, and 5-hydoxytryptophan 2B...
Bone cancer pain (BCP) remains a difficult clinical problem. This study examined whether pioglitazone, peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is effective for attenuating BCP, and investigated the interaction between activation of PPARγ phosphatase tensin homolog deleted from chromosome 10 (PTEN) / mammalian target rapamycin (mTOR) signal in spinal dorsal horn (SDH) BCP rats. We tested effects intrathecal (i.t.) injection adenovirus-mediated PTEN (Ad-PTEN),...
Respiratory variation in the internal jugular vein (IJVV) has not shown promising results predicting volume responsiveness ventilated patients with low tidal (Vt) prone position. We aimed to determine whether baseline respiratory IJVV value measured by ultrasound might predict fluid adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion (PSF) Vt.According results, included were divided into two groups: those who responded expansion, denoted responder group, and did respond,...
Affiliated Drum-Tower Hospital of Medical College Nanjing Universit y, Department Anaesthesiology, Nanjing, China
Objective: Although the 24-h urinary sodium excretion (USE) is golden criterion for evaluate intakes, it always seemed infeasible. Nowadays, there were three methods, Kawasaki method, INTERSALT and Tanaka method estimating USE. But no evidence showed these methods would be fit Chinese common population. This study was to validate estimates USE using 3 in Design method: The a substudy of Prospective Urban Rural Epidemiology (PURE), 120 participants (60 from rural 60 city) aged 35 70 years (at...
Objective To investigate the effects of Akt3 gene knockout on neuropathic pain behaviors induced by chronic constriction injury sciatic nerve (CCI). Methods Experiment was divided into two groups: group(Akt3-/-, n=12), wild type group(WT, n=12). Randomly numbered, right mice were received operation injury. Paw withdrawal mechanical threshold (PWMT) and paw thermal latency (PWTL) tested day 1 before 1, 3, 5, 7, 10, 14, 17, 21 after CCI. Results The basic values PWMT(right:...
Abstract Background: Respiratory variation in the internal jugular vein (IJVV) has not shown promising results predicting volume responsiveness ventilated patients with low tidal (Vt) prone position. We aimed to determine whether baseline respiratory IJVV value measured by ultrasound might predict fluid adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion (PSF) Vt. Methods: According results, included were divided into two groups: those who responded expansion, denoted...