A5002689868- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Forest ecology and management
- HIV Research and Treatment
- Neuroendocrine Tumor Research Advances
- Nutrition, Health and Food Behavior
- Eicosanoids and Hypertension Pharmacology
- Tree Root and Stability Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Forest Ecology and Biodiversity Studies
- Plant Virus Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Seedling growth and survival studies
- Nutritional Studies and Diet
- Hepatitis C virus research
- Neurological Disease Mechanisms and Treatments
- Toxin Mechanisms and Immunotoxins
- Glycosylation and Glycoproteins Research
- Forest Insect Ecology and Management
- Sodium Intake and Health
- Cerebrovascular and genetic disorders
University of New Mexico
2024-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Shanghai Institutes for Biological Sciences
2024
University of Nottingham
2023-2024
State Key Laboratory of Cardiovascular Disease
2015
Fu Wai Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Stockholm University
1993
Swedish University of Agricultural Sciences
1993
Cerebral small vessel disease (SVD) contributes to approximately 50% of human dementias world-wide and pose a burden the health care system worldwide. Early endothelial/blood-brain barrier (BBB) dysfunction is an important contributor pathogenesis SVD. Sphingosine-1-phosphate (S1P), membrane-derived signaling sphingolipid, regulates BBB integrity by binding its receptor isoform 1 (S1PR1) on endothelial cells. We previously showed that activation S1PR1 using SEW2871, selective agonist,...
Microbial corrosion poses a significant threat to architectural heritage worldwide. This study used metagenomics investigate microbial diversity and taxonomic groups present in the door walls of Ji family’s residential houses, as well their biological functions chemical cycles. Taxonomic annotation revealed predominant taxa associated with wall corrosion, shedding light on potential impact structural integrity. Moreover, analyzing metabolites pathways these communities allows for thorough...
The establishment of latent cellular and anatomical viral reservoirs is a major obstacle to achieving cure for people infected by HIV. Mesenteric lymph nodes (MLNs) are one the most important Suboptimal levels antiretroviral (ARVs) drugs in these difficult-to-penetrate limitations current therapy (ART) regimens. This study aimed design assess highly lipophilic ester prodrugs dolutegravir (DTG) formulated with long-chain triglyceride (LCT) delivery DTG reservoir mesenteric MLNs. A number...
Non-derivatized cytokinins were analysed by liquid chromatography/mass spectrometry (LC/MS). The effluent from a capillary reversed-phase high-performance chromatography column was introduced into the ion source of double-focusing mass spectrometer via frit interface, and ions generated fast atom bombardment (FAB) with 1% glycerol in mobile phase acting as matrix. Positive FAB spectra obtained for base, riboside, ribotide glucoside forms cytokinins. found to provide useful information...
Endothelial dysfunction and blood-brain barrier (BBB) leakage have been suggested as a fundamental role in the development of cerebral small vessel disease (SVD) pathology. However, molecular cellular mechanisms that link hypoxic hypoperfusion BBB disruption remain elusive. Sphingosine-1-phosphate (S1P) regulates integrity by binding to its receptor isoform 1 (S1PR<sub>1</sub>) on endothelial cells. This study tested hypothesis triggers capillary S1PR<sub>1</sub> disruption, which...
Aims The purpose of this study was to investigate the pharmacokinetics daily oral doses lamivudine administered healthy Chinese subjects for 1 week. Methods Twenty‐four were enrolled, 12 males and females, all between ages 18 40 years. After an overnight fast, received a single dose 100 mg lamivudine. Blood obtained before administration at regular intervals 24 h post dose. Subsequent given once total 7 days. On last day another full pharmacokinetic profile postdose. Timed urine collections...
Objective: Although the 24-h urinary sodium excretion (USE) is golden criterion for evaluate intakes, it always seemed infeasible. Nowadays, there were three methods, Kawasaki method, INTERSALT and Tanaka method estimating USE. But no evidence showed these methods would be fit Chinese common population. This study was to validate estimates USE using 3 in Design method: The a substudy of Prospective Urban Rural Epidemiology (PURE), 120 participants (60 from rural 60 city) aged 35 70 years (at...
Efficient delivery of antiretroviral agents to lymph nodes is important decrease the size HIV reservoir within lymphatic system. Lamivudine (3TC) used in first-line regimens for treatment HIV. As a highly hydrophilic small molecule, 3TC not predicted associate with chylomicrons and therefore should have negligible uptake into intestinal lymphatics following oral administration. Similarly, amounts are be transported peripheral subcutaneous (SC) injection due faster flow rate blood comparison...