A5066321093- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Stroke Rehabilitation and Recovery
- Psychosomatic Disorders and Their Treatments
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Cerebrospinal fluid and hydrocephalus
- Peripheral Neuropathies and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Complications and Syndromes
- S100 Proteins and Annexins
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Venous Thromboembolism Diagnosis and Management
- Retinal and Optic Conditions
- Neurological Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
University of New Mexico
2019-2025
Presbyterian Hospital
2024
New York Hospital Queens
2024
Columbia University
2024
NewYork–Presbyterian Hospital
2024
King's College London
2023
University of New Mexico Hospital
2020-2022
The Ohio State University Wexner Medical Center
2012-2019
The Ohio State University
2012-2019
National Center for Advancing Translational Sciences
2019
Thrombectomy is currently recommended for eligible patients with stroke who are treated within 6 hours after the onset of symptoms.We conducted a multicenter, randomized, open-label trial, blinded outcome assessment, thrombectomy in to 16 they were last known be well and had remaining ischemic brain tissue that was not yet infarcted. Patients proximal middle-cerebral-artery or internal-carotid-artery occlusion, an initial infarct size less than 70 ml, ratio volume on perfusion imaging 1.8...
Atherosclerotic intracranial arterial stenosis is an important cause of stroke that increasingly being treated with percutaneous transluminal angioplasty and stenting (PTAS) to prevent recurrent stroke. However, PTAS has not been compared medical management in a randomized trial.
<i>Background:</i> Small, unrandomized studies have indicated that pharmacologically induced blood pressure elevation may improve function in ischemic stroke, presumably by improving flow to ischemic, but noninfarcted tissue (which be diffusion-perfusion mismatch on MRI). We conducted a pilot, randomized trial evaluate effects of and perfusion acute stroke. <i>Methods:</i> Consecutive series patients with large were randomly assigned (‘treated’ patients, n = 9) or...
Anecdotal reports suggest that a loss of distinction between gray (GM) and white matter (WM) as adjudged by CT scan predicts poor outcome in comatose patients after cardiac arrest. To address this, we quantitatively assessed GM WM intensities at various brain levels arrest.Patients for whom consultation was requested within 24 hours arrest were identified with the use computerized database tracks neurological consultations our institution. Twenty-five complete medical records scans available...
Enrollment in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke Intracranial Stenosis (SAMMPRIS) trial was halted due to high risk of or death within 30 days enrollment percutaneous transluminal angioplasty stenting arm relative medical arm. This analysis focuses on patient procedural factors that may have been associated with periprocedural cerebrovascular events trial.Bivariate multivariate analyses were performed evaluate whether variables cerebral ischemic...
Background and Purpose— Treatment with the iron chelator, deferoxamine mesylate (DFO), improves neurological recovery in animal models of intracerebral hemorrhage (ICH). We aimed to evaluate feasibility, safety, tolerability varying dose-tiers DFO patients spontaneous ICH, determine maximum tolerated dose be adopted future efficacy studies. Methods— This was a multicenter, phase-I, dose-finding study using Continual Reassessment Method. administered by intravenous infusion for 3 consecutive...
Agonism of protease-activated receptor (PAR) 1 by activated protein C (APC) provides neuro- and vasculoprotection in experimental neuroinjury models. The pleiotropic PAR1 agonist, 3K3A-APC, reduces neurological injury promotes vascular integrity; 3K3A-APC proved safe human volunteers. We performed a randomized, controlled, blinded trial to determine the maximally tolerated dose (MTD) ischemic stroke patients.
Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to restore oxygen and nutrient supply affected brain tissue following an ischemic stroke. By stimulating vessel growth, angiogenesis may stabilize perfusion, thereby promoting neuronal survival, plasticity, neurologic recovery. However, therapeutic after stroke faces challenges: angiogenesis-induced vessels have higher than normal permeability, treatment promote exacerbate outcomes in patients. The...
To study the impact of neurologic prognostication on decision to withdraw life-sustaining therapies (LST) in comatose patients resuscitated after cardiac arrest.The authors prospectively studied a consecutive series post-resuscitation referred for at single center 4 years. For most patients, was not sought due early death or rapid return consciousness. Prognostication based Glasgow Coma Score (GCS) and Brainstem Reflex (BRS), with EEG cortical evoked potentials (CEP), which were graded as...
Dopamine receptors regulate glutamatergic neurotransmission and Na + ,K -ATPase via protein kinase A (PKA) dopamine- cAMP-regulated phosphoprotein of 32 kDa (DARPP-32)-dependent signaling. Consequently, dopamine receptor activation may modulate neonatal hypoxic–ischemic (H–I) neuronal damage in the selectively vulnerable putamen enriched with dopaminergic receptors. Piglets subjected to two durations hypoxia followed by asphyxic cardiac arrest were treated a D1-like (SCH23390) or D2-like...
<h3>Objective:</h3> To assess the evidence and make evidence-based recommendations for acute interventions to reduce brain injury in adult patients who are comatose after successful cardiopulmonary resuscitation. <h3>Methods:</h3> Published literature from 1966 August 29, 2016, was reviewed with classification of relevant articles. <h3>Results recommendations:</h3> For whom initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or fibrillation (VF) out-of-hospital arrest...
Background and Purpose— Traumatic brain injury (TBI) leads to nearly 300 000 annual US hospitalizations increased lifetime risk of acute ischemic stroke (AIS). Occurrence AIS immediately after TBI has not been well characterized. We evaluated acutely its impact on outcome. Methods— A prospective database moderate severe survivors, admitted inpatient rehabilitation at 22 Brain Injury Model Systems centers their referring acute-care hospitals, was analyzed. Outcome measures were incidence,...
Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of on cerebral blood flow velocity changes and constructed an age-adjusted predictive model in patients.We identified patients with admitted between 1991 1999 a prospective database. Eighty-one patients, complete medical records examinations vessels interest, were included. Patients subdivided into 2 groups by age: younger, <68 years (n=47) older, >/=68...
The purpose of this was to evaluate the neuroprotective effects near-infrared (NIR) light using an in-vivo rodent model traumatic brain injury (TBI), controlled cortical impact (CCI), and characterize changes at behavioral biochemical levels.NIR upregulates mitochondrial function, decreases oxidative stress. Mitochondrial stress apoptosis are important in TBI. NIR enhanced cell viability function previous in-vitro TBI models, supporting potential benefits.Sprague-Dawley rats were divided...