A5079914106- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Tracheal and airway disorders
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Ischemic Stroke Management
- Esophageal and GI Pathology
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Optical Imaging and Spectroscopy Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Pain Management
- Cerebrovascular and Carotid Artery Diseases
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
Johns Hopkins Medicine
2015-2025
Johns Hopkins University
2015-2025
Zeteo Tech (United States)
2024
University of Baltimore
2023
Johns Hopkins Hospital
2008-2019
Johns Hopkins Bayview Medical Center
2019
Universidad del Valle
2016-2017
University of Maryland, Baltimore
2008-2016
National Patient Safety Foundation
2016
Oregon Health & Science University
2016
Evidence suggests that a specific subcortical pathway synaptically linking the anterior thalamic nuclear complex (AN) to hypothalamus and midbrain is important in expression of pentylenetetrazol (PTZ) seizures. Perturbation neuronal activity along this path via focal disruption or chemical inhibition significantly raises seizure threshold. Recent data has demonstrated electrical stimulation within hypothalamic component inhibited current frequency dependent fashion. Similar experiments were...
To evaluate the role of 23.4% saline in management transtentorial herniation (TTH) patients with supratentorial lesions.Consecutive clinically defined TTH treated (30 to 60 mL) were included a retrospective cohort. Factors associated successful reversal determined.Seventy-six events occurred 68 admitted intracerebral hemorrhage (n = 29), subarachnoid 16), stroke 8), brain tumor subdural hematoma 5), epidural 1), and meningitis 1). In addition saline, hyperventilation (70% events), mannitol...
To determine the effect of continuous hypertonic (3%) saline/acetate infusion on intracranial pressure (ICP) and lateral displacement brain in patients with cerebral edema.Retrospective chart review.Neurocritical care unit a university hospital.Twenty-seven consecutive edema (30 episodes), including head trauma (n = 8), postoperative 5), nontraumatic hemorrhage infarction 6).Intravenous 3% to increase serum sodium concentrations 145 155 mmol/L.A reduction mean ICP within first 12 hrs...
Objective To evaluate the effect of intravenous bolus administration 23.4% saline (8008 mOsm/L) on refractory intracranial hypertension (RIH) in patients with diverse diseases. Design Retrospective chart review. Setting A neurosciences intensive care unit a university hospital. Patients We present eight and total 20 episodes increased pressure (ICP) resistant to standard modes therapy. Five had subarachnoid hemorrhage, one patient traumatic brain injury, tumor, another spontaneous basal...
Analysis of patient data from a new neuroscience intensive care unit (NSICU) permitted evaluation whether such specialty ICU favorably altered clinical outcomes in critically ill patients, and model produced an efficient use resources. A retrospective review was performed to compare (1) the outcomes, as defined by percent mortality disposition at discharge, between patients with primary diagnosis intracerebral hemorrhage treated 1995 medical or surgical ICUs those same facility NSICU 1997;...
Object Opioid administration after major intracranial surgery is often limited by a presumed lack of need and concern that opioids will adversely affect the postoperative neurological examination. The authors conducted prospective study to evaluate incidence, severity, treatment pain in patients who underwent surgery. Methods One hundred eighty-seven (77 men 110 women, mean age 52 ± 15 years, weight 78.1 19.9 kg) either supratentorial (129 patients) or infratentorial (58 procedures....
Interruption of the connection between mammillary bodies and anterior nucleus thalamus in guinea pigs, by discrete bilateral electrolytic lesions mammillothalamic tract, resulted essentially complete protection from behavioral electroencephalographic convulsant action lethal effect pentylenetetrazol. This result demonstrates that their rostral efferent connections are important for propagation perhaps initiation generalized seizures.
BACKGROUND: Difficult airway cases can quickly become emergencies, increasing the risk of life-threatening complications or death. Emergency management outside operating room is particularly challenging. METHODS: We developed a quality improvement program—the Airway Response Team (DART)—to improve emergency room. DART was implemented by team anesthesiologists, otolaryngologists, trauma surgeons, medicine physicians, and managers in 2005 at The Johns Hopkins Hospital Baltimore, Maryland....
Summary: High‐frequency electrical stimulation of mammillary nuclei (MN) rat posterior hypothalamus resulted in a significant increase seizure threshold induced by pentylenetetrazol (PTZ). The anticonvulsant effect was frequency and intensity specific. Stimulation at 100 Hz (1–5V, 30–200 μA) afforded protection against EEG behavioral manifestations PTZ seizures. either low (5 Hz), high intensities (8–20 V, 300–800 μA), or outside the histologically verified MN target region did not...
The frequency of bedside percutaneous tracheostomies is increasing in intensive care medicine, and both safety efficiency are critical elements continuing success this procedure. Prioritizing patient safety, a tracheostomy team was created at our institution to provide expertise surgery, anesthesiology, respiratory, technical support. This study performed evaluate the metrics outcome, care, cost-benefit analysis multidisciplinary Johns Hopkins Percutaneous Tracheostomy Program.A review for...
To develop and assess the feasibility of a new standardized protocol to guide tracheostomy decannulation.Descriptive review quality improvement project.A project was conducted in inpatient setting tertiary urban academic hospital. Adult patients who had received for whom indication resolved were included. A multidisciplinary task force reviewed input from clinicians caring developed screening, capping, decannulation. The primary outcome measured successful decannulation.Fifty-seven screened...