A5046277371- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Esophageal and GI Pathology
- Pharmacological Effects and Toxicity Studies
- Helicobacter pylori-related gastroenterology studies
- Neuroscience and Neural Engineering
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Ion channel regulation and function
- Esophageal Cancer Research and Treatment
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Clinical Nutrition and Gastroenterology
- Gastrointestinal disorders and treatments
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
Stanford University
2016-2025
Stanford Medicine
2007-2024
California Pacific Medical Center
2013-2024
University of Southern California
2024
Queen Mary University of London
2023
Stanford Health Care
2016-2022
University of Wisconsin–Madison
2022
New York University Press
2022
University of Houston
2022
Neurological Surgery
1985-2017
The International League Against Epilepsy (ILAE) and the Bureau for (IBE) have come to consensus definitions terms epileptic seizure epilepsy. An is a transient occurrence of signs and/or symptoms due abnormal excessive or synchronous neuronal activity in brain. disorder brain characterized by an enduring predisposition generate seizures neurobiologic, cognitive, psychological, social consequences this condition. definition epilepsy requires at least one seizure.
The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. purpose such revision is to recognize that some types can have either focal or generalized onset, allow when the onset unobserved, include missing types, and adopt more transparent names. Because current knowledge insufficient form scientifically based classification, 2017 Classification (practical) on 1981 Classification, extended in 2010. Changes following: (1) "partial" becomes...
We report a multicenter, double-blind, randomized trial of bilateral stimulation the anterior nuclei thalamus for localization-related epilepsy.Participants were adults with medically refractory partial seizures, including secondarily generalized seizures. Half received and half no during 3-month blinded phase; then all unblinded stimulation.One hundred ten participants randomized. Baseline monthly median seizure frequency was 19.5. In last month phase stimulated group had 29% greater...
Summary This companion paper to the introduction of International League Against Epilepsy ( ILAE ) 2017 classification seizure types provides guidance on how employ classification. Illustration is enacted by tables, a glossary relevant terms, mapping old new suggested abbreviations, and examples. Basic extended versions are available, depending desired degree detail. Key signs symptoms seizures (semiology) used as basis for categories that focal or generalized from onset with unknown onset....
To report long-term efficacy and safety results of the SANTE trial investigating deep brain stimulation anterior nucleus thalamus (ANT) for treatment localization-related epilepsy.This follow-up is a continuation previously reported 5- vs 0-V ANT stimulation. Long-term began 13 months after device implantation with parameters adjusted at investigators' discretion. Seizure frequency was determined using daily seizure diaries.The median percent reduction from baseline 1 year 41%, 69% 5 years....
Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus thalamus reduces seizure activity. We embarked on an open-label pilot study to determine initial safety tolerability bilateral (ANT), a range appropriate parameters, begin gather efficacy data.We report five patients (three men, two women; age range, 24-47 years), with follow-up between 6 36 months. All had intractable partial epilepsy. Four also...
Summary: Stimulation of centromedian (CM) thalamic nuclei has been proposed as a treatment for seizures. We implanted programmable subcutaneous (s.c.) stimulators into CM bilaterally in 7 patients with intractable epilepsy to test feasibility and safety. was on or off 3‐month blocks, washout period double‐blind, cross‐over protocol. Stimuli were delivered 9O‐μs pulses at 65 pulses/s, 1 min each 5 2 h/day, voltage set half the sensory threshold. safe well‐tolerated, mean reduction...
The existence of a lag phase during the gastric emptying solid foods is controversial. It has been hypothesised that among other early events, stomach requires period time to process food particles small enough be handled as liquid. At present no standardised curve fitting techniques exist for characterisation and quantification or rate solids liquids. We have evaluated ability modified power exponential function define parameters two different meals. Dual labelled meals were administered 24...
To the Editor: We appreciate comments of our fifteen colleagues who commented on “definitions” article (1–3). Before responding to substance, we first would like assert that definition epilepsy expressed eis open revision, but it was carefully considered. The process forming spanned three years an ILAE subcommittee, and definitions passed through levels nonanonymous review (subcommittee, Commission Diagnostic Methods, Executive Committee), then anonymous in Epilepsia, done with a guest...
Abstract Gastric emptying of digestible solids occurs after trituration food particles. Non‐digestible are thought to empty with phase III the migrating motor complex (MMC). The aim this study was determine if a non‐digestible capsule given meal empties from stomach return fasting MMC or during fed pattern solid meal. Fifteen normal subjects underwent antroduodenal manometry and ingestion radiolabelled SmartPill wireless pH pressure capsule. In five subjects, studied in period by ingesting...
OBJECTIVES Gastroparesis is an increasingly recognized disorder. Its prevalence in the United States unknown. We examined trends, characteristics, and outcomes of gastroparesis-related hospitalizations during 1995–2004. METHODS The publicly available Healthcare Cost Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) comprises a nationally representative sample 5–8 million per year. Gastroparesis-related were identified using International Classification Diseases (ICD-9) code 536.3...
Summary Objective We evaluated the efficacy and safety of deep brain anterior thalamus stimulation after 7 10 years, report incidence sudden unexpected death in epilepsy (SUDEP) overall mortality adults Stimulation Anterior Nucleus Thalamus for Epilepsy (SANTÉ) study. Methods After 3‐month blinded 9‐month unblinded phases, subjects continued to be assessed during long‐term follow‐up (LTFU) later a therapy access phase (CAP), further characterize adverse events SUDEP. Stimulus parameter...
Evidence suggests that a specific subcortical pathway synaptically linking the anterior thalamic nuclear complex (AN) to hypothalamus and midbrain is important in expression of pentylenetetrazol (PTZ) seizures. Perturbation neuronal activity along this path via focal disruption or chemical inhibition significantly raises seizure threshold. Recent data has demonstrated electrical stimulation within hypothalamic component inhibited current frequency dependent fashion. Similar experiments were...