A5103238393- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Pharmaceutical studies and practices
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Electrolyte and hormonal disorders
- Treatment of Major Depression
- Infectious Encephalopathies and Encephalitis
- Electroconvulsive Therapy Studies
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Renal and related cancers
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neural Engineering
- CAR-T cell therapy research
- Neonatal and fetal brain pathology
University of Zurich
2024
University Hospital of Zurich
2024
Vion Pharmaceuticals (United States)
2012-2022
Sunovion (United States)
2012-2022
Sunovion (United Kingdom)
2012-2021
Thomas Jefferson University
2016
New York University
2016
Temple University
2016
Tufts University
2016
GlaxoSmithKline (United States)
2003-2009
Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus thalamus reduces seizure activity. We embarked on an open-label pilot study to determine initial safety tolerability bilateral (ANT), a range appropriate parameters, begin gather efficacy data.We report five patients (three men, two women; age range, 24-47 years), with follow-up between 6 36 months. All had intractable partial epilepsy. Four also...
In 31 consecutive patients who were admitted to an epilepsy monitoring unit, we prospectively determined whether the aware of having seizures. On admission, all stated that they knew at least some their Eight 23 with classifiable epileptic seizures recognized occasionally unaware During telemetry, following full recovery consciousness after each seizure, asked had recently a seizure. For control purposes, same question random times. Among seizures, there no false-positive answers. Only 6...
Summary Objective To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate ( ESL ) in patients with refractory partial‐onset seizures. Methods This randomized, placebo‐controlled, double‐blind, parallel‐group, phase III study was conducted at 173 centers 19 countries, including United States Canada. Eligible were aged ≥16 years had uncontrolled seizures despite treatment 1–2 antiepileptic drugs AED s). After an 8‐week baseline period, randomized to once‐daily placebo (n =...
<b>Objective: </b> To compare the cognitive effects of lamotrigine vs topiramate as adjunctive therapy in adults with epilepsy. <b>Methods: A multicenter, double-blind, randomized, prospective study was conducted partial seizures. Lamotrigine or introduced an to carbamazepine phenytoin and titrated over 8 weeks target doses. These drugs were maintained another (maintenance phase) without dosage changes. The primary endpoint change from screening end maintenance phase a combined analysis...
Summary Objective To assess the efficacy and safety of eslicarbazepine acetate ( ESL ) as monotherapy in North American patients with partial‐onset seizures POS ). Methods This multicenter, randomized, double‐blind “withdrawal to monotherapy” study used historical control data comparator. Adults medically uncontrolled by one two antiepileptic drugs gradually converted monotherapy. Following an 8‐week baseline period, were randomized 2:1 receive 1,600 mg (n = 128) or 1,200 QD 65) for 18...
To determine the relation between depressive symptoms and seizure severity among people with epilepsy.A postal questionnaire was used to survey a nationwide community sample about seizures depression. The Seizure Severity Questionnaire (SSQ) assessed bothersomeness of components. Centers for Epidemiological Studies-Depression scale categorized levels depression.Respondents as having current severe (SEV, n = 166), mild-moderate (MOD, 74), or no depression (NO, 443) differed significantly in...
Summary: Purpose : A double‐blind, randomized, placebo‐controlled clinical trial to examine the safety, tolerability, and antiepileptic activity of ganaxolone in patients after withdrawal from other drugs during presurgical evaluations was performed. Methods Fifty‐two eligible were withdrawn randomized receive (24 patients) or placebo (28 for up 8 days. Ganaxolone administered at a dose 1500 mg/d on day 1 1875 days 2 8. Dosing occurred three times per day: immediately breakfast, lunch,...
Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD) anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It extensively converted after oral administration to eslicarbazepine, and believed exert its effect through inhibition voltage-gated sodium channels. The possible role ESL monotherapy treat POS has not yet been established. This study was an 18-week, multicenter, randomized double-blind trial gradual conversion in adults with well controlled by 1–2...
To assess the safety and efficacy of once-daily (QD) adjunctive eslicarbazepine acetate (ESL).This post-hoc pooled analysis three randomized, placebo-controlled trials (2093-301, -302, -304) involved adults with refractory partial-onset seizures (POS) receiving 1-3 antiepileptic drugs (AEDs). All studies included 8-week baseline, 2-week titration, 12-week maintenance periods. Patients were randomized equally to placebo, ESL 400mg (studies 301, 302), 800mg, or 1200mg QD. The primary endpoint...
Positron emission tomography (PET) has proven useful in epilepsy surgery for its ability to identify unilateral temporal hypometabolism (UTH), which is predictive of good surgical outcome. The significance bilateral (BTH) not known.We identified all patients who had marked reduction lobe metabolism relative the cerebellar hemispheres and compared their clinical features treatment outcomes with those control UTH.BTH was evident 10% PET scans at our institution. We these age-matched controls...
To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy.This post hoc pooled analysis 2 randomized double-blind studies (093-045 -046) included adults with partial-onset seizures medically uncontrolled by 1 or antiepileptic drugs (AEDs). Following baseline period (8 weeks), eligible patients were 2:1 to receive ESL 1,600 mg 1,200 once daily for 18 weeks; primary endpoint was study exit meeting predefined criteria (signifying worsening seizure control). In each study,...
Background: The self-administered iPad-based Cleveland Clinic Cognitive Battery (C3B) was designed specifically for the efficient screening of cognitive functioning older adults in a primary care setting. Objective: 1) Generate regression-based norms from healthy participants to enable demographic corrections facilitate clinical interpretation; 2) estimate test-retest reliability and practice effects; 3) examine ability discriminate mild impairment (MCI) aging; 4) d etermine validity...
Investigators have found it difficult to separate patients with nonepileptic seizures (NES) from those true epileptic (ES) using quantitative measures of neuropsychological test performance. We examined qualitative response characteristics on the California Verbal Learning Test 41 undergoing continuous video/audio-EEG monitoring in an effort distinguish these patient groups (12 left temporal [LT] foci, 11 right [RT] and 18 NES). NES explicitly recognized fewer target words compared ES...
Thirty-one cases of persistent stridor during infancy, which on study proved to be congenital origin, were analyzed. The breakdown these is as follows: 4 laryngotracheomalacia, 3 vascular anomalies, angiomas, 1 mucous membrane, laryngeal cyst. remaining (18) belong the so-called "benign" group in that no specific etiology could demonstrated and evolution was spontaneously favorable. In every case stridor, precise underlying cause should looked for. addition clinical assessment investigation...
IntroductionThe efficacy and safety of apomorphine sublingual film (APL-130277; APL) for the on-demand treatment "OFF" episodes associated with Parkinson's disease (PD) was demonstrated in a double-blind trial. Herein we describe ability patients to receive effective tolerable APL dose titration during open-label phase.MethodsAdult levodopa-responsive PD were enrolled. In practically defined "OFF," observed FULL "ON" after their usual morning carbidopa/levodopa (CD/LD) then following each...