A5011299962- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Advanced Chemical Sensor Technologies
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- 14-3-3 protein interactions
- Transcranial Magnetic Stimulation Studies
Medtronic (United States)
2005-2022
Karger Publishers (Switzerland)
2013
University of Manitoba
1997-1998
Summary Objective We evaluated the efficacy and safety of deep brain anterior thalamus stimulation after 7 10 years, report incidence sudden unexpected death in epilepsy (SUDEP) overall mortality adults Stimulation Anterior Nucleus Thalamus for Epilepsy (SANTÉ) study. Methods After 3‐month blinded 9‐month unblinded phases, subjects continued to be assessed during long‐term follow‐up (LTFU) later a therapy access phase (CAP), further characterize adverse events SUDEP. Stimulus parameter...
Abstract The need for novel, efficacious, antiseizure therapies is widely acknowledged. This study investigates in humans the feasibility, safety, and efficacy of high‐frequency electrical stimulation (HFES; 100–500Hz) triggered by automated seizure detections. Eight patients were enrolled this study, which consisted a control an experimental phase. HFES was delivered directly to epileptogenic zone (local closed‐loop) four indirectly, through anterior thalami (remote closed‐loop), other...
To assess the safety, tolerability and efficacy of high-frequency periodic thalamic stimulation in inoperable mesial temporal epilepsy usefulness intracranially evoked responses for assessment anatomical uniformity lead placement.Four subjects were implanted with leads aimed at anterior nuclei. Six weeks later, Soletra IPGs activated using parameters similar to closed-loop trial's (mean: 175 Hz; 4.1 V; 90 mus; 1 min ON, 5 OFF). Efficacy was assessed by comparing percentage change seizure...
<b><i>Background/Aims:</i></b> In conjunction with therapeutic stimulation, next-generation deep brain stimulation (DBS) devices may offer the ability to record and analyze neural signals, providing for unprecedented insight into DBS effects on networks. This work was conducted evaluate an implantable, clinical-grade system that permits concurrent recording using a large animal (ovine) model recently developed study epilepsy....
To better understand the mechanism of action deep brain stimulation (DBS) for epilepsy and to investigate implantable device features, it is desirable have a large animal model evaluate clinical-grade systems. This study assessed suitability an ovine this purpose.Animals were anesthetized surgery 1.5 T MRIs collected. Unilateral anterior thalamic DBS leads, hippocampal depth electrodes catheters implanted using frameless stereotactic system. Evoked responses local field potentials collected...
Deep brain stimulation (DBS) of the anterior nucleus thalamus (ANT) is an effective therapy for patients with drug-resistant focal epilepsy. Best practices surgical targeting ANT can be refined as new information becomes available regarding sites.To conduct a retrospective analysis relationship between outcomes (seizure reduction during year 1) and DBS lead locations in subjects from SANTÉ pivotal trial (Stimulation Epilepsy) based upon recent clinical findings.Postoperative images (n = 101)...
Deep Brain Stimulation (DBS) within the Papez circuit is under investigation as a treatment for epilepsy and Alzheimer's disease. We previously reported effects of stimulation at nodes this network (anterior thalamic nucleus hippocampus) on hippocampal activity in large animal model, using chronic implantable, clinical-grade system that permits concurrent recording.In study we extended earlier work to compare fornix DBS evoked potentials (EPs) local field potential (LFP) hippocampus, assess...
Background Deep brain stimulation ( DBS ) together with concurrent EEG recording has shown promise in the treatment of epilepsy. A novel device is capable combining these 2 functions and may prove valuable epilepsy dogs. However, stereotactic implantation electrodes dogs not yet been evaluated. Objective To evaluate feasibility safety implanting stimulating normal using Brainsight system to function a device. Animals Four male intact Greyhounds, confirmed be by clinical neurologic...
This paper introduces a new method for estimating the excitability of brain networks. The motivation this research was to develop system that can track pathological changes in excitability, diseases such as epilepsy. ability may provide anticipating seizures and intervening therapeutically. Four normally healthy canines were implanted with Medtronic Activia PC+S deep stimulation sensing system. devices used probe circuit Papez, electrical anterior nucleus thalamus measure evoked potentials...
ObjectiveTo assess based on a single-center data from multicenter trial (Stimulation of the Anterior Nucleus for Thalamus Epilepsy (SANTE)), role anatomical connectivity and other factors (e.g., stimulating electrode placement) efficacy electro-therapy anterior thalamic nuclei (ATN), node in Papez network, pharmaco-resistant seizures.Data sourceAdults with at least 6 seizures /month were enrolled this trial. Percent seizure reduction was compared between subjects emerging inside Papez's...
Background: In prior reports, we described the design and initial performance of a fully implantable, bi-directional neural interface system for use in deep brain other neurostimulation applications. Here provide an update on chronic, long-term sensing using traditional 4-contact leads extend those results to include directional 8-contact leads. Methods: Seven ovine subjects were implanted with stimulation (DBS) at different nodes within Circuit Papez: four unilateral anterior nucleus...
This paper discusses the challenges and opportunities designing technology for deep brain stimulation (DBS). DBS is currently approved treatment of movement disorders such as Parkinson Disease, essential tremor dystonia, a number studies are underway to determine its clinical efficacy epilepsy, resistant depression, obsessive compulsive disorder (OCD). Designing system complex engineering problem, drawing on diverse fields applied physics, circuit design, algorithms biology. But fundamental...