A5066960699- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Nuclear Receptors and Signaling
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Ginkgo biloba and Cashew Applications
- Neurological diseases and metabolism
- Pain Management and Treatment
- RNA regulation and disease
Cleveland Clinic
2014-2025
Cleveland Clinic Lerner College of Medicine
2016-2025
The Neurological Institute
2010-2025
Collaborative Group (United States)
2021
Cerner (United States)
2000-2021
Case Western Reserve University
2020
University of Minnesota
2010-2018
University of Minnesota System
2012
International Neuromodulation Society
2010
Medical College of Wisconsin
2007
Upper-extremity impairment after stroke remains a major therapeutic challenge and target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation promote functional reorganization ipsilesional cortex in 12 individuals persistent (1-3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events...
OBJECTIVE AND IMPORTANCE: Deep brain stimulation (DBS) is an accepted treatment for patients with Parkinson’s disease refractory to medication. The efficacy of this therapy has led increasing numbers receiving DBS implants. Importantly, physicians caring implantable neurostimulators must be aware guidelines these patients, including the use therapeutic ultrasound, diathermy, and imaging studies such as magnetic resonance (MRI). CLINICAL PRESENTATION: We describe a case serious, permanent...
Abstract Purpose To compare the magnetic resonance imaging (MRI)‐related heating per unit of whole body averaged specific absorption rate (SAR) a conductive implant exposed to two different 1.5‐Tesla/64 MHz MR systems. Materials and Methods Temperature changes at electrode contacts deep brain stimulation lead were measured using fluoroptic thermometry. The leads placed in typical surgical configuration within gel‐filled phantom human head torso. MRI was performed transmit/receive coils on...
The use of magnetic resonance imaging (MRI) in patients with neurostimulation systems used for deep brain stimulation requires the utmost care, and no individual should undergo an MR examination absence empirical evidence that procedure can be performed safely. risks performing MRI neurostimulators include those associated heating, field interactions, induced currents, functional disruption these devices. exact safety recommendations particular system regard to pulse generator, leads,...
Control over postinjury CNS plasticity is a major frontier of science that, if conquered, would open new avenues for treatment neurological disorders. Here we investigate the functional, physiological, and structural changes in cerebral cortex associated with chronic deep brain stimulation cerebellar output, approach that has been shown to improve postischemia motor recovery rodent model cortical infarcts. Long–Evans rats were pretrained on pasta-matrix retrieval task, followed by induction...
Objective The experience with deep brain stimulation (DBS) for pain is largely based on uncontrolled studies targeting the somatosensory pathways, mixed results. We hypothesized that limbic neural pathways would modulate affective sphere of and alleviate suffering. Methods conducted a prospective, double‐blinded, randomized, placebo‐controlled, crossover study DBS ventral striatum/anterior limb internal capsule (VS/ALIC) in 10 patients poststroke syndrome. One month after bilateral DBS, were...
Abstract The effect of subthalamic nucleus (STN) stimulation on cortical electroencephalographic activity was examined in 10 patients with Parkinson's disease and 4 epilepsy. Evoked potentials were created by time‐locking electroencephalography to the onset electrical delivered through lead implanted STN who had previously undergone deep brain (DBS) surgery. different patterns evoked response, including single‐ paired‐pulse as well burst stimulation, explored. Cortical single pulses observed...
The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD).To evaluate the influence heterozygosity for parkin mutation on onset age a sample families with least 2 PD-affected members.Clinical and genetic study.Twenty collaborative clinical sites.Patients familial PD collected GenePD study. Studied were selected (1) affected sibling pairs sharing alleles identical by state (D6S305) or (2) 1 more family members...
We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser (G2019S), is associated with approximately 5 to 6% PD cases and 1 2% idiopathic cases, making it the common known genetic cause Studies mutations have produced wide range estimates, possibly due differences study design recruitment, including particular between samples versus sporadic A...
Microtubule-associated protein tau (MAPT) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association MAPT region PD in a large cohort familial cases recruited by GenePD Study. In addition, postmortem brain samples from patients neurologically normal controls were used to evaluate whether expression 3-repeat 4-repeat isoforms MAPT, neighboring genes Saitohin (STH) KIAA1267, are altered...
While beta oscillations often occur within the parkinsonian basal ganglia, how these emerge from a naive state and change with disease severity is not clear. To address this question, progressive, nonhuman primate model of Parkinson's was developed using staged injections MPTP. Within each (naive, mild, moderate, severe), spontaneous local field potentials were recorded throughout sensorimotor globus pallidus. In state, (11–32 Hz) occurred in half recordings, indicating pallidus are...
A number of studies suggest that Parkinson's disease (PD) is associated with alterations neuronal activity patterns in the basal-ganglia-thalamocortical circuit. There are limited electrophysiological data, however, describing how premotor cortex, which involved movement and decision-making, likely impacted PD. In this study, spontaneous local field potential (LFP) single unit were recorded dorsal area nonhuman primates both naïve parkinsonian state using...
Highlights•Acute DN-DBS increases ipsilesional corticomotor excitability in chronic stroke.•Acute DBS effects are associated with motor functional gains after DN-DBS.•CST and DTC white matter integrity influence physiologic of DN-DBS.•TMS-based biomarkers may be useful for therapies.AbstractBackgroundDeep brain stimulation the dentate nucleus (DN-DBS) is an emerging therapy to improve upper extremity (UE) function stroke. This study sought investigate mechanisms acute stroke survivors...
Purpose: To prospectively determine the pattern of functional magnetic resonance (MR) imaging activation at 3 T produced by deep brain stimulation (DBS) subthalamic nucleus (STN) for treatment Parkinson disease and to safety DBS electrode during MR T. Materials Methods: Informed consent was obtained from all subjects participating in study, study protocol approved institutional review board Cleveland Clinic Foundation HIPAA compliant. After extensive phantom testing lead systems, five...
Abstract Purpose To compare the MRI‐related heating per unit of specific absorption rate (SAR) profile a conductive implant between two 1.5‐Tesla/64 MHz MR systems using transmit/receive (t/r) head coil configuration. Materials and Methods Deep brain stimulation (DBS) leads were configured within gel‐filled phantom human torso. Temperature variation at each four contacts bilaterally‐placed was monitored fluoroptic thermometry. MRI performed t/r coils different‐generation 1.5‐Tesla from same...