A5057520132- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Cardiovascular Syncope and Autonomic Disorders
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Vector-borne infectious diseases
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Neurogenesis and neuroplasticity mechanisms
- Innovations in Medical Education
- Motor Control and Adaptation
- Optical Imaging and Spectroscopy Techniques
- Zebrafish Biomedical Research Applications
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Problem and Project Based Learning
- Clinical Reasoning and Diagnostic Skills
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Ophthalmology and Eye Disorders
- Viral Infections and Vectors
Cleveland Clinic
2010-2024
The Neurological Institute
2010-2024
Cleveland Clinic Lerner College of Medicine
2013-2021
Case Western Reserve University
2020-2021
Control over postinjury CNS plasticity is a major frontier of science that, if conquered, would open new avenues for treatment neurological disorders. Here we investigate the functional, physiological, and structural changes in cerebral cortex associated with chronic deep brain stimulation cerebellar output, approach that has been shown to improve postischemia motor recovery rodent model cortical infarcts. Long–Evans rats were pretrained on pasta-matrix retrieval task, followed by induction...
Over 500,000 Americans have strokes every year, making stroke the leading cause for disability in United States and industrialized world. New treatments to improve poststroke motor recovery are needed.To investigate a novel approach enhancing that involves chronic, electrical stimulation of ascending cerebellar output combined with training.Adult Sprague-Dawley rats underwent unilateral endothelin-1 injections dominant cerebral cortex placement chronic stimulating electrode contralateral...
Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression long-term potentiation markers in perilesional cerebral cortex.To further investigate cellular changes associated chronic LCN ischemic by examining neurogenesis along cerebellothalamocortical pathway.Rats were trained on pasta matrix task, followed induction ischemia electrode...
Few preclinical or clinical studies have evaluated the effect of anesthetics on motor evoked potentials (MEPs), either alone in presence conditioning stimuli such as deep brain stimulation (DBS). In this study we effects two commonly used anesthetic agents, propofol and ketamine (KET), MEPs elicited by intra-cortical microstimulation cortex a rodent model with without DBS dentatothalamocortical (DTC) pathway. The anesthesia MEP amplitudes during DTC were found to be highly dose dependent....
Crossed cerebellar diaschisis (CCD) is a functional deficit of the hemisphere resulting from loss afferent input consequent to lesion contralateral cerebral hemisphere. It manifested as reduction metabolism and blood flow and, depending on severity duration, it can result in atrophy, phenomenon known crossed atrophy (CCA). While CCA has been well-demonstrated humans, remains poorly characterized animal models stroke. In this study we evaluated effects cortical ischemia anatomy using an...
ORIGINAL RESEARCH article Front. Physiol., 09 August 2011Sec. Exercise Physiology volume 2 - 2011 | https://doi.org/10.3389/fphys.2011.00047
The clinical diagnosis of progressive supranuclear palsy can be challenging, as the presentation overlaps with that Parkinson's disease and multiple system atrophy. We sought to examine practical utility radiologic markers by investigating whether these could distinguish between patients palsy-Richardson syndrome (PSP-RS) those based on imaging obtained in a typical setting, not prospective research environment.This retrospective study included 13 PSP-RS who were followed for either...
To evaluate the prevalence and impact of migraine as a comorbidity for patients with Postural Orthostatic Tachycardia Syndrome (POTS).
We aim to increase awareness of the diagnostic challenges Lyme neuroborreliosis (LNB) in order decrease treatment delays due unfamiliarity unique clinical manifestations setting rising disease incidence.
Lyme disease is a multisystem disorder transmitted through the Ixodes tick and most commonly diagnosed in northeastern mid-Atlantic states, Wisconsin, Minnesota, though its borders are expanding setting of climate change. Approximately 10%–15% untreated cases will develop neurologic manifestations neuroborreliosis (LNB). Due to varying presentations, LNB presents diagnostic challenges associated with delay treatment. We discuss three admitted our referral center traditionally low-incidence...
Monday, April 27April 14, 2020Free AccessMethods and Utility of Quantitative Brainstem Measurements in Progressive Supranuclear Palsy versus Parkinson’s Disease a Routine Clinical Setting (662)Jessica Cooperrider, Brent Bluett, Stephen JonesAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.662 Letters to the Editor
Introduction Postural orthostatic tachycardia syndrome (POTS) is an underdiagnosed and undertreated dysautonomia. We hypothesize that there are differences between primary care physicians (PCPs) patients’ perceptions of POTS correcting these discrepancies may improve patient care. Methods Two groups were surveyed: Patients who received for symptoms from a Cleveland Clinic neurologist or nurse practitioner patients family medicine internal physicians. Results PCPs (81%) rated lightheadedness...