A5076771471- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Microbial Natural Products and Biosynthesis
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Power Transformer Diagnostics and Insulation
- Neural dynamics and brain function
- Angiogenesis and VEGF in Cancer
- High voltage insulation and dielectric phenomena
- Vestibular and auditory disorders
- Oral microbiology and periodontitis research
- Biomarkers in Disease Mechanisms
- Spine and Intervertebral Disc Pathology
- Microwave Engineering and Waveguides
- Advanced Neuroimaging Techniques and Applications
- Mesenchymal stem cell research
- Musculoskeletal pain and rehabilitation
- Neurological disorders and treatments
- Bacterial Genetics and Biotechnology
- Non-Destructive Testing Techniques
- Lipid Membrane Structure and Behavior
Pusan National University
2013-2025
Abbott (United States)
2021-2024
International Neuromodulation Society
2021-2024
Plano Cancer Institute
2021
Cleveland Clinic Lerner College of Medicine
2013-2019
Cleveland Clinic
2012-2018
Johns Hopkins University
2017
Inje University Ilsan Paik Hospital
2017
Hospital for Sick Children
2006-2016
The Neurological Institute
2015
Abstract Microglia actively survey the brain microenvironment and play essential roles in sculpting synaptic connections during development. While microglial functions adult are less clear, activated microglia can closely appose neuronal cell bodies displace axosomatic presynaptic terminals. Microglia-mediated stripping of terminals is considered neuroprotective, but cellular molecular mechanisms poorly defined. Using 3D electron microscopy, we demonstrate that inhibitory from cortical...
Foxp3(+) regulatory T cells (Tregs) are crucial for maintaining cell tolerance, but their role in humoral autoimmunity remains unclear. To address this, we combined a model of autoantibody-dependent arthritis (K/BxN) with Foxp3 mutant scurfy mice to generate Treg-deficient K/BxN mice, referred as K/BxNsf mice. The disease symptoms were exacerbated, and this coincided increases extrafollicular Th cells, follicular germinal centers. Surprisingly, the exhibited an abnormal accumulation mature...
Over 500,000 Americans have strokes every year, making stroke the leading cause for disability in United States and industrialized world. New treatments to improve poststroke motor recovery are needed.To investigate a novel approach enhancing that involves chronic, electrical stimulation of ascending cerebellar output combined with training.Adult Sprague-Dawley rats underwent unilateral endothelin-1 injections dominant cerebral cortex placement chronic stimulating electrode contralateral...
The carbohydrates galactose and 3-sulfogalactose, found on sphingolipids in myelin, interact with each other via a carbohydrate-carbohydrate interaction (CCI). In oligodendrocytes, this triggers signaling cascade resulting cytoskeletal rearrangements reorganization of glycolipids proteins at the cellular surface. These can also be triggered by synthetic multivalent glycoconjugates. report, we describe synthesis glycan-coated silica nanoparticles their subsequent binding to cultured...
Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding local neural substrates consequently mechanism action responsible therapeutic effects.Epidural recordings (ESR) are collected from electrodes placed in epidural space. ESR contains multi-modality signal components such as evoked response (due to tonic or BurstDR™ waveforms), muscle response, artifact, cardiac response. The...
Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord epidural cortical are common therapeutic options increasingly used to treat a large variety neurological psychiatric conditions. Despite their remarkable success, there limitations which if overcome, could enhance outcomes potentially reduce side-effects. Micromagnetic (μMS) was introduced address some these limitations. One most properties is that μMS theoretically capable...
Abstract Background Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not fully understood, including how electrode placement relation spinal neuroanatomy influences epidural recordings (ESRs). To characterize this relationship, study utilized applied at various anatomical sections of column, levels intervertebral disc regions correlating...
Vascular calcification is a critical pathological hallmark of cardiovascular diseases. Although previous studies have indicated that M1 macrophages significantly promote calcification, the exact underlying mechanisms remain unclear. This study examined whether semaphorin 4D (Sema4D), class IV involved in atherosclerosis development, secreted by and contributes to vascular smooth muscle cells (VSMCs). We observed elevated expression secretion Sema4D both M2 macrophages, with higher levels...
Abstract In this study we investigated the molecular mechanism of activation-induced cell death (AICD) inhibition mediated by a p70 inhibitory killer Ig-like receptor (KIR3DL1, also called NKB1) in Jurkat T cells. Using stable transfectants that express KIR or CD8-KIR fusion proteins have shown for first time inhibits, ligation-independent manner, AICD induced PHA, PMA/ionomycin, anti-CD3 Ab. The appears to result from blockade Fas ligand induction upon activation transfectants. Moreover,...
Patients having stereo-electroencephalography (SEEG) electrode, subdural grid or depth electrode implants have a multitude of electrodes implanted in different areas their brain for the localization seizure focus and eloquent areas. After implantation, patient must remain hospital until pathological area is found possibly resected. During this time, these patients offer unique opportunity to research community because any number behavioral paradigms can be performed uncover neural correlates...
Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression long-term potentiation markers in perilesional cerebral cortex.To further investigate cellular changes associated chronic LCN ischemic by examining neurogenesis along cerebellothalamocortical pathway.Rats were trained on pasta matrix task, followed induction ischemia electrode...
Streptomyces setonii (ATCC 39116) degrades various single aromatic compounds such as phenol or benzoate via an ortho-cleavage pathway using catechol 1,2-dioxygenase (C12O). A PCR degenerate primers based on the conserved regions of known C12O-encoding genes amplified a 0.45-kbp DNA fragment from S. total DNA. Southern hybridization analysis and size-selected library screening product probe led to isolation 6.4-kbp fragment, which genetic locus was found be located within 1.4-kbp fragment....