A5014158607- Neurological disorders and treatments
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Neuroscience and Neural Engineering
- Spine and Intervertebral Disc Pathology
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Pain Management and Placebo Effect
- Spinal Dysraphism and Malformations
- Management of metastatic bone disease
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Medical Imaging and Analysis
- Spinal Cord Injury Research
- Cerebral Venous Sinus Thrombosis
- Occupational Health and Safety Research
- Forensic Entomology and Diptera Studies
- Cell Image Analysis Techniques
University of California, San Diego
2025
University of Southern California
2002-2015
The Ohio State University
2012-2014
The Ohio State University Wexner Medical Center
2012-2014
Mission Heritage Medical Group
2014
Neurological Surgery
2010-2013
International Neuromodulation Society
2012
Versar (United States)
2011
Northwestern University
2010
University of Chicago
2010
CpG methylation is involved in a wide range of biological processes vertebrates as well plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, Dnmt3b, are known to have DNA methyltransferase activity mouse human. It has been proposed that de novo observed early embryos predominantly carried out by the Dnmt3a Dnmt3b methyltransferases, while Dntm1 believed be responsible for maintaining established patterns upon replication. Analysis sites methylated vivo using bisulfite genomic sequencing...
OBJECTIVE Metastatic epidural spinal cord compression is a potentially devastating complication of cancer and estimated to occur in 5% 14% all patients. It best treated surgically. Minimally invasive spine surgery has the potential benefits decreased surgical approach–related morbidity, blood loss, hospital stay, time mobilization. CLINICAL PRESENTATION A 36-year-old man presented with worsening back pain lower extremity weakness. Workup revealed metastatic adenocarcinoma lung at T4 T5....
Posttraumatic stress disorder (PTSD) is a disabling and prevalent psychiatric with limited effective treatment options. In addition to the clinical features of disease, pathologic changes in electroencephalogram (EEG), including decreased alpha power, have been reported.To determine if magnetic brain stimulation can induce normalization EEG abnormalities improve symptoms PTSD preliminary, open-label evaluation.We reviewed prospectively-collected data on 21 veterans that were...
OBJECTIVE Placement of deep brain stimulators (DBSs) currently involves the use both image-based stereotaxy and intraoperative microelectrode recording (MER). Interpretations MER data integration with anatomical are manual processes. Hidden Markov models (HMMs) commonly used in signal processing, speech recognition, a wide array biologic applications. METHODS A 6-state HMM was designed trained for evaluation simulated surgery subthalamic nucleus (STN) DBS. RESULTS The accuracy identifying...
DNA methylation has been proposed to be important in many biological processes and is the subject of intense study. Traditional bisulfite genomic sequencing allows detailed high-resolution pattern analysis each molecule with haplotype information across a few hundred bases at locus, but lacks capacity gather voluminous data. Although recent technological developments are aimed assessing patterns high-throughput manner genome, cannot accurately assembled when reads short or hybridization...
El objetivo del estudio multicéntrico, aleatorizado, no ciego y cruzado fue determinar la seguridad eficacia de un dispositivo que administra estimulación tónica tradicional en ráfagas a pacientes con dolor crónico axial y/o extremidades. Luego una prueba exitosa, 100 individuos fueron aleatorizados para recibir modo durante las primeras 12 semanas, luego el otro siguientes semanas. Este piloto presentó se sometieron período mes generador pulso externo. Durante prueba, dio como resultado...