A5041765061- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Neonatal and fetal brain pathology
- Transcranial Magnetic Stimulation Studies
- Lysosomal Storage Disorders Research
- Memory and Neural Mechanisms
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Neuroscience and Music Perception
- Glycogen Storage Diseases and Myoclonus
- Pharmacology and Obesity Treatment
- Non-Invasive Vital Sign Monitoring
- Diabetes Management and Research
- Regulation of Appetite and Obesity
University of Kentucky
2016-2025
Pennsylvania State University
2006-2009
Brighton General Hospital
1983
Abstract The need for novel, efficacious, antiseizure therapies is widely acknowledged. This study investigates in humans the feasibility, safety, and efficacy of high‐frequency electrical stimulation (HFES; 100–500Hz) triggered by automated seizure detections. Eight patients were enrolled this study, which consisted a control an experimental phase. HFES was delivered directly to epileptogenic zone (local closed‐loop) four indirectly, through anterior thalami (remote closed‐loop), other...
A study of hyponatraemia in the in-patients a Geriatric Department during 10-month period showed that 77 patients (11.3%) had plasma sodium concentrations below 130 mmol/1. Thirty-one (4.5%) severe less than 125 mmol/l. Seventy-three per cent hyponatraemias were iatrogenic caused by diuretic or intravenous fluid therapy. Hydrochlorothiazide/amiloride combination has greatest tendency to produce compared all other diuretics ( P <0.01). Clinical features attributable present 61 %. Nine needed...
Accumulation of amyloid-β (Aβ) plays an important role in Alzheimer's disease (AD) pathology. There is growing evidence that disordered sleep may accelerate AD pathology by impeding the physiological clearance Aβ from brain occurs normal sleep. Therapeutic strategies for improving quality therefore help slow progression. It well documented composition and dynamics are sensitive to ambient temperature. We compared metrics derived polysomnography 12-month-old female 3xTg-AD mice (n = 8)...
Automated seizure blockage is a top research priority of the American Epilepsy Society. This delivery modality (referred to herein as contingent or closed loop) requires for implementation detection algorithm control therapy via suitable device. The authors address many potential advantages this over conventional alternatives (periodic continuous), and challenges it poses in design analysis trials assess efficacy safety-in particular context direct electrical stimulation brain tissue....
Improved understanding of the interaction between state vigilance (SOV) and seizure onset has therapeutic potential. Six rats received injections tetanus toxin (TeTX) in ventral hippocampus that resulted chronic spontaneous seizures. The distribution SOV before 486 seizures was analyzed for a total 19 d recording. Rapid eye movement sleep (REM) exploratory wake, both which express prominent hippocampal theta rhythm, preceded 47 34%, 81%, all Nonrapid (NREM) nonexploratory neither expresses...
Brain-computer interfaces (BCIs) offer disabled individuals the means to interact with devices by decoding electroencephalogram (EEG). However, intent in fine motor tasks can be challenging, especially stroke survivors cortical lesions. Here, we attempt decode graded finger extension from EEG patients left-hand paresis and healthy controls. Participants extended their fingers one of four levels: low, medium, high, or 'no-go' (none), while hand, muscle (electromyography: EMG), brain (EEG)...
The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage fluorescent materials. CLN3 disease, or juvenile Batten is the most common NCL that caused mutations in Ceroid Lipofuscinosis, Neuronal 3 (CLN3) gene. Sleep disturbances among symptoms associated with disease deteriorate patients' life quality, yet this understudied and has not been delineated animal models disease. current study utilised PiezoSleep,...
Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of acute mortality and chronic neurologic morbidity in infants children. HIE the most common neonatal seizures, seizure activity neonates can be clinical, with both EEG behavioral symptoms, subclinical only activity, or just behavioral. The accurate detection these different manifestations extent to which they differ their effects on brain continues concern medicine. Most experimental studies interaction between...
The proportion, number of bouts, and mean bout duration different vigilance states (Wake, NREM, REM) are useful indices dynamics in experimental sleep research. These metrics estimated by first scoring state, sometimes using an algorithm, based on electrophysiological measurements such as the electroencephalogram (EEG) electromyogram (EMG), computing their values from score sequence. Isolated errors scores can lead to large discrepancies metrics. But most algorithms classifying state EEG/EMG...
Neural activity can be modulated by applying a polarizing low-frequency (≪100 Hz) electric field (PLEF). Unlike conventional pulsed stimulation, PLEF stimulation has graded, modulatory effect on neuronal excitability, and permits the simultaneous recording of during suitable for continuous feedback control. We tested prototype system that allows with minimal artifact in chronic tetanus toxin animal model (rat) hippocampal epilepsy spontaneous seizures. Depth electrode local potentials...
Experimental manipulation of sleep in rodents is an important tool for analyzing the mechanisms and related disorders humans. Sleep restriction systems have relied past on manual sensory stimulation recently more sophisticated automated means delivering same. The ability to monitor track behavior through electroencephalogram (EEG) other modalities provides opportunity implement selective that targeted at particular stages with flexible control over their amount, duration, timing. In this...
Clinical sleep scoring involves tedious visual review of overnight polysomnograms by a human expert. Many attempts have been made to automate the process training computer algorithms such as support vector machines and hidden Markov models (HMMs) replicate scoring. Such supervised classifiers are typically trained on scored data then validated out-of-sample data. Here we describe methodology based HMMs for an recording without benefit initial model. The number states in is not known priori...
The goals of Epilepsy Benchmark Area III involve identifying areas that are ripe for progress in terms controlling seizures and patient symptoms light the most recent advances both basic clinical research. These were developed with an emphasis on potential new therapeutic strategies will reduce seizure burden improve quality life patients epilepsy. In particular, we continue to support proposition a better understanding how initiated, propagated, terminated different forms epilepsy is...
Abstract Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian remains unclear. To gain insight into diversity, we examined architecture the spiny basal murid rodent Acomys cahirinus . First, used a piezoelectric system validated for Mus musculus monitor both species. We also included wild M. control alterations generated by laboratory-reared conditions Using this comparative framework,...
Most seizure prediction methods are based on nonlinear dynamic techniques, which highly computationally expensive, thus limiting their clinical usefulness. The authors propose a different approach for that uses stochastic Markov chain model. Seizure (Ts) and interictal (Ti) durations were measured from 11 rats treated with 3-mercaptopropionic acid. duration of Ts was used to predict the time (Ti2) next one. Ti distributed bimodally into short (S) long (L), generating four probable...
Resting state networks (RSNs) have been found in human brains during awake resting states. RSNs are composed of spatially distributed regions which spontaneous activity fluctuations temporally and dynamically correlated. A new computational framework for reconstructing with EEG data has developed the present study. The proposed utilizes independent component analysis (ICA) on short-time Fourier transformed inverse source maps imaged from statistical correlation to generate cortical...
There is resurgent interest in the role played by autonomic dysfunction seizure generation. Advances wearable sensors make it convenient to track many variables patient populations. This study assesses peri-ictal changes surrogate measures of activity for their predictive value epilepsy patients. We simultaneously recorded fronto-central surface EEG and submental EMG score vigilance state, intracranial (iEEG) compute several electrophysiological (EV), measurements (heart rate, blood volume...