A5014574021- Ultrasonics and Acoustic Wave Propagation
- Speech and Audio Processing
- Sleep and Wakefulness Research
- Ultrasound Imaging and Elastography
- Circadian rhythm and melatonin
- Structural Health Monitoring Techniques
- Advanced Adaptive Filtering Techniques
- Non-Destructive Testing Techniques
- Color Science and Applications
- Voice and Speech Disorders
- Acoustic Wave Phenomena Research
- Industrial Vision Systems and Defect Detection
- Neural dynamics and brain function
- Advanced Chemical Sensor Technologies
- Spectroscopy and Chemometric Analyses
- Phonetics and Phonology Research
- Target Tracking and Data Fusion in Sensor Networks
- Image and Signal Denoising Methods
- Radar Systems and Signal Processing
- Hearing Loss and Rehabilitation
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Optical Imaging and Spectroscopy Techniques
- Electrical and Bioimpedance Tomography
- Speech Recognition and Synthesis
University of Kentucky
2014-2024
Michigan State University
2023
City College of San Francisco
2022
Royal North Shore Hospital
2018
Google (United States)
2015
Drexel University
1989-2003
Illinois Institute of Technology
1987-1989
Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history these inbred panels may influence detectable allelic and phenotypic diversity. existing panel common strains reflects historical selection biases, recombinant have low All such be subject to consequences inbreeding depression. Collaborative Cross (CC) is a mouse population with high diversity that being constructed using randomized design...
Traditionally, sleep studies in mammals are performed using electroencephalogram/electromyogram (EEG/EMG) recordings to determine sleep-wake state. In laboratory animals, this requires surgery and recovery time causes discomfort the animal. study, we evaluated performance of an alternative, noninvasive approach utilizing piezoelectric films wakefulness mice by simultaneous EEG/EMG recordings. The detect animal's movements with high sensitivity regularity piezo output signal, related regular...
This work presents a non-invasive high-throughput system for automatically detecting characteristic behaviours in mice over extended periods of time, useful phenotyping experiments. The classifies time intervals on the order 2 to 4 seconds as corresponding motions consistent with either active wake or inactivity associated sleep. A single Polyvinylidine Difluoride (PVDF) sensor cage floor generates signals from motion resulting pressure. paper develops linear classifier based robust features...
Objective Clinical observations report excessive sleepiness immediately following traumatic brain injury (TBI); however, there is a lack of experimental evidence to support or refute the benefit sleep injury. The aim this study investigate acute post-traumatic sleep. Methods Sham, mild moderate diffuse TBI was induced by midline fluid percussion (mFPI) in male C57BL/6J mice at 9:00 21:00 evaluate injury-induced behavior and wake onset, respectively. Sleep profiles were measured post-injury...
A significant effort in biomedical sciences has been made to examine relationships between sex and the mechanisms underlying various disease states behaviors, including sleep. Here, we investigated biological differences sleep using male female C57BL/6J mice (n = 267). Physiological parameters were recorded for 48-h non-invasive piezoelectric cages determine total sleep, non-rapid eye movement (NREM) rapid (REM)-like wakefulness (WAKE). We fit hierarchical generalized linear mixed models...
The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage fluorescent materials. CLN3 disease, or juvenile Batten is the most common NCL that caused mutations in Ceroid Lipofuscinosis, Neuronal 3 (CLN3) gene. Sleep disturbances among symptoms associated with disease deteriorate patients' life quality, yet this understudied and has not been delineated animal models disease. current study utilised PiezoSleep,...
INTRODUCTION: Seizures are made up of the coordinated activity networks neurons. It follows that control neurons in pathologic circuits epilepsy could allow for disease. In non-human disease models epilepsy, optogenetics has been effective at stopping seizure-like by increasing inhibitory tone or decreasing excitation. However, this not shown human brain tissue. Many genetic means achieving channelrhodopsin expression possible humans, and vector-mediated methods susceptible to...
An ultrasonic backscattered signal from material comprised of quasiperiodic scatterers exhibit redundancy over both its phase and magnitude spectra. This paper addresses the problem estimating mean-scatterer spacing ultrasound using spectral characterized by autocorrelation (SAC) function. Mean-scatterer estimates are compared for techniques that use cepstrum SAC A-scan models consist a collection regular with Gamma distributed spacings embedded in diffuse uniform spacings. The model...
The quasiperiodicity of regularly spaced scatterers results in characteristic patterns the spectra backscattered ultrasonic signals from which mean scatterer spacing can be estimated. has been considered for classifying certain biological tissue. This paper addresses problem estimating ultrasound using frequency-smoothed spectral autocorrelation (SAC) function. SAC function exploits differences between phase spectrum resolvable quasiperiodic and unresolvable uniformly distributed (diffuse)...
Color co-occurrence method (CCM) texture statistics were used as input variables for a backpropagation (BP) neural network weed classification model. Thirty-three unique CCM statistic inputs generated 40 images per class, within six class data set. The following classes studied: giant foxtail, large crabgrass, common lambsquarter, velvetleaf, ivyleaf morningglory, and clear soil surface. was to build different variable models the BP network, consisting of various combinations hue,...
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated cohorts 2-3 weeks after complete high thoracic (T4) spinal cord injury (SCI). Here we employed long-term blood pressure telemetry test, firstly, efficacy of daily versus acute GBP treatment in modulating AD response stimuli at 2 3 post-injury....
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse opioids along with increased use drugs like heroin fentanyl, has led an epidemic in addiction overdose deaths. most common cause death is opioid-induced respiratory depression (OIRD), a life-threatening rate thought be caused by stimulation receptors inspiratory-generating regions brain. Studies mice have revealed that variation opiate lethality associated strain differences,...
Breast cancer diagnosis through ultrasound tissue characterization was studied using receiver operating characteristic (ROC) analysis of combinations acoustic features, patient age, and radiological findings. A feature fusion method devised that operates even if only partial diagnostic data are available. The ROC methodology uses ordinal dominance theory bootstrap resampling to evaluate A(z) confidence intervals in simple as well paired analyses. combined had an 0.96 with a interval at...
The demand for high-quality apples remains strong throughout the year, as they are one of top three most popular fruits globally. However, apple industry faces challenges in monitoring and managing postharvest losses due to invasive pests during long-term storage. In this study, effect codling moth (CM) (Cydia pomonella [Linnaeus, 1758]), detrimental apples, on quality fruit was investigated under different storage conditions. Specifically, Gala were evaluated their qualities such firmness,...
Split-spectrum processing of broadband ultrasonic signals coupled with order statistic filtering has proven to be effective in improving the flaw-to-clutter ratio backscattered signals. It is shown that an optimal rank can obtained a prior knowledge and underlying distributions. The filter performs well where flaw clutter echoes have good statistical separation given quantile region representing particular (e.g. minimum, median, maximum). Order filters are analyzed for situation which...