A5033163178- Animal Vocal Communication and Behavior
- Neurotransmitter Receptor Influence on Behavior
- Animal Behavior and Reproduction
- Neuroscience of respiration and sleep
- Marine animal studies overview
- Gut microbiota and health
- Tryptophan and brain disorders
- Advanced biosensing and bioanalysis techniques
- Neuropeptides and Animal Physiology
- Ergonomics and Musculoskeletal Disorders
- Radiation Therapy and Dosimetry
- Stroke Rehabilitation and Recovery
- Stress Responses and Cortisol
- bioluminescence and chemiluminescence research
- Musculoskeletal pain and rehabilitation
- Advanced MRI Techniques and Applications
- Cannabis and Cannabinoid Research
- Advanced Fluorescence Microscopy Techniques
- Avian ecology and behavior
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
Washington University in St. Louis
2023-2024
Jackson Laboratory
2020-2023
Howard Hughes Medical Institute
2020-2021
University of California, San Francisco
2020-2021
Escuela Politécnica del Ejército
2017
Abstract Genetically encoded fluorescent calcium indicators allow cellular-resolution recording of physiology. However, bright, genetically targetable that can be multiplexed with existing tools in vivo are needed for simultaneous imaging multiple signals. Here we describe WHaloCaMP, a modular chemigenetic indicator built from bright dye-ligands and protein sensor domains. Fluorescence change WHaloCaMP results reversible quenching the bound dye via strategically placed tryptophan. is...
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse opioids along with increased use drugs like heroin fentanyl, has led an epidemic in addiction overdose deaths. most common cause death is opioid-induced respiratory depression (OIRD), a life-threatening rate thought be caused by stimulation receptors inspiratory-generating regions brain. Studies mice have revealed that variation opiate lethality associated strain differences,...
The flexible control of sequential behavior is a fundamental aspect speech, enabling endless reordering limited set learned vocal elements (syllables or words). Songbirds are phylogenetically distant from humans but share both the capacity for learning and neural circuitry that includes direct pallial-brainstem projections. Based on these similarities, we hypothesized songbirds might likewise be able to learn flexible, moment-by-moment over vocalizations. Here, demonstrate Bengalese finches...
Genetically encoded fluorescent calcium indicators have revolutionized neuroscience and other biological fields by allowing cellular-resolution recording of physiology during behavior. However, we currently lack bright, genetically targetable in the near infrared that can be used animals. Here, describe WHaloCaMP, a modular chemigenetic indicator built from bright dye-ligands protein sensor domains targeted to specific cell populations. Fluorescence change WHaloCaMP results reversible...
Abstract The gut‐brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion microbiome by antibiotic treatment alters cocaine‐induced behavioral sensitization C57BL/6J male mice. Some reports suggest that correlated with drug self‐administration behavior Here, we profile composition naïve its response two collaborative cross (CC) strains. These strains...
Abstract In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014, leading an epidemic in addiction and overdose deaths. The most common cause death is opioid-induced respiratory depression (OIRD), a life-threatening rate thought be caused by stimulation receptors inspiratory-generating regions brain. Studies mice have revealed that variation opiate lethality associated with strain differences, suggesting sensitivity OIRD genetically determined. We first...
Abstract The flexible control of sequential behavior is a fundamental aspect speech, enabling endless reordering limited set learned vocal elements (syllables or words). Songbirds are phylogenetically distant from humans but share both the capacity for learning and neural circuitry that includes direct pallial-brainstem projections. Based on these similarities, we hypothesized songbirds might likewise be able to learn flexible, moment by-moment over vocalizations. Here, demonstrate Bengalese...
Abstract The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization C57BL/6J male mice. Some reports suggest that correlated with drug self-administration behavior Here we profile composition naïve its response two Collaborative Cross (CC) strains. These strains...