A5039931061- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Allergic Rhinitis and Sensitization
- Epigenetics and DNA Methylation
- Dermatologic Treatments and Research
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Nail Diseases and Treatments
- Cancer Cells and Metastasis
- Gut microbiota and health
- Nonmelanoma Skin Cancer Studies
- Skin and Cellular Biology Research
- Immunodeficiency and Autoimmune Disorders
- Cutaneous lymphoproliferative disorders research
- RNA Interference and Gene Delivery
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Xi'an Jiaotong University
2014-2024
Qingdao University of Science and Technology
2024
Handan College
2024
Beijing Friendship Hospital
2022
Capital Medical University
2022
Creative Commons
2022
Brigham and Women's Hospital
2016-2018
Harvard University
2016-2018
82th Hospital of Pla
2014
Abstract Atopic dermatitis (AD) is a chronic skin disease caused by immune dyshomeostasis and accompanied severe pruritus. Although oxidative stress mechanical scratching can aggravate AD inflammation, treatment targeting often overlooked, the efficiency of mechano-chemically synergistic therapy remains unclear. Here, we find that enhanced phosphorylation focal adhesion kinase (FAK) associated with scratch-exacerbated AD. We then develop multifunctional hydrogel dressing integrates...
Abstract Background Psoriasis is an inflammatory skin disease associated with multiple comorbidities and substantially diminishes patients’ quality of life. The gut microbiome has become a hot topic in psoriasis as it been shown to affect both allergy autoimmunity diseases recent studies. Our objective was identify differences the fecal microbial composition patients compared healthy individuals unravel microbiota profiling this autoimmune disease. Results We collected samples from 30...
Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in lives. Updated, comprehensive and systematic evidence-based guidelines to guide clinical practice urgently needed.We collaborated with multidisciplinary experts formulate this guideline based on evidences of already published literature, focusing 13 questions elected a panel experts. We adopted Grading Recommendations Assessment, Development Evaluation (GRADE) system form classification...
Hydrogel-based wearable epidermal sensors (HWESs) have attracted widespread attention in health monitoring, especially considering their colorimetric readout capability. However, it remains challenging for HWESs to work at extreme temperatures with long term stability due the existence of water. Herein, a transparent sensor thermal compatibility and smart multi-signals monitoring is developed, based on an anti-freezing anti-drying hydrogel high transparency (over 90% transmittance),...
The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established clinical trials, but there a lack multicenter data regarding its effectiveness real-world settings. Patients moderate-to-severe PN who initiated treatment between July 2023 January 2024, follow-up period at least 16 weeks 10 hospitals China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, dermatology life quality index...
Background Dupilumab is an antibody against interleukin-4 receptor α, used in the treatment of atopic dermatitis (AD). Objectives To evaluate efficacy and safety dupilumab adult Chinese patients with moderate-to-severe AD. Methods In this randomized, double-blind, placebo-controlled, parallel-group, phase III study, conducted between December 2018 February 2020, AD received (300 mg) or placebo once every 2 weeks for 16 weeks, were followed up 12 weeks. The primary endpoint was proportion...
Abstract The cohesin complex participates in the organization of 3D genome through generating and maintaining DNA loops. Stromal antigen 2 (STAG2), a core subunit complex, is frequently mutated various cancers. However, impact STAG2 inactivation on organization, especially long-range enhancer-promoter contacts subsequent gene expression control cancer, remains poorly understood. Here we show that depletion melanoma cells leads to expansion topologically associating domains (TADs) enhances...
Microchannels often serve as highways for cancer migration, and their topology largely determines the migration efficiency. Curvature, a topological parameter in biological systems, has recently been reported to be efficient guiding cell polarization migration. Curvature varies widely along curved microchannels, while its influence on remains elusive. Here, we recapitulated observed clinical tumor tissues with hydrogels, studied how cells respond curvature. We found that bend more...
Traditional research on skin diseases has mainly focused biological characteristics for a long time. Recently, the integration of biomechanics and mechanobiology introduced mechanical factors into disease research. The interaction between skin's physiological pathological changes gradually been transformed in clinical diagnosis treatment. two emerging fields, mechanodiagnostics mechanotherapy, have developed to address needs. However, clinicians often lack comprehensive understanding...
INTRODUCTION: Seizures are made up of the coordinated activity networks neurons. It follows that control neurons in pathologic circuits epilepsy could allow for disease. In non-human disease models epilepsy, optogenetics has been effective at stopping seizure-like by increasing inhibitory tone or decreasing excitation. However, this not shown human brain tissue. Many genetic means achieving channelrhodopsin expression possible humans, and vector-mediated methods susceptible to...
Cell division cycle 20 (CDC20) is a regulatory molecule and serves critical roles at multiple points of the cell cycle. Recent evidence indicates that CDC20 may serve an oncogenic role in number human cancer types. However, primary cutaneous squamous carcinoma (cSCC) has not been studied, to best our knowledge. The aim present study was investigate whether how involved tumorigenesis cSCC. results revealed expression significantly increased cSCC tissues lines, its associated with pathological...
Abstract Atopic dermatitis (AD) is a common disease clinically characterized by chronic recurrent eczematous lesions, dry skin, and pruritus. AD can negatively impact patients’ quality of life. The prevalence in China has been increasing during the past few decades. Based on most recent advances treatment AD, we updated 2014 version Guidelines for Diagnosis Treatment Dermatitis regarding definition, epidemiology, pathogenesis, clinical classification, diagnosis, prevention, AD.