A5011241116- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Endometriosis Research and Treatment
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Autoimmune Bullous Skin Diseases
- Ovarian cancer diagnosis and treatment
- Spondyloarthritis Studies and Treatments
- Gut microbiota and health
- Immune Cell Function and Interaction
- Hair Growth and Disorders
- Food Allergy and Anaphylaxis Research
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Uterine Myomas and Treatments
- Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Contact Dermatitis and Allergies
- Salivary Gland Disorders and Functions
Peking University
2016-2025
Peking University People's Hospital
2016-2025
Southwest University
2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
Peking Union Medical College Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Ministry of Education of the People's Republic of China
2023-2024
Shanxi Medical University
2024
Second Hospital of Shanxi Medical University
2024
Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic recurrent with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria been proposed for the diagnosis AD. Although clinical features childhood AD widely studied, there has less large-scale study on adult/adolescent The aim this was to investigate symmetrical eczema/AD and propose Chinese diagnostic AD.A hospital-based performed. Forty-two dermatological centers...
Background Dupilumab is an antibody against interleukin-4 receptor α, used in the treatment of atopic dermatitis (AD). Objectives To evaluate efficacy and safety dupilumab adult Chinese patients with moderate-to-severe AD. Methods In this randomized, double-blind, placebo-controlled, parallel-group, phase III study, conducted between December 2018 February 2020, AD received (300 mg) or placebo once every 2 weeks for 16 weeks, were followed up 12 weeks. The primary endpoint was proportion...
Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks and interleukin-13 signaling. This trial aimed to evaluate the efficacy safety in Chinese with moderate-to-severe AD. Methods: multicenter, randomized, double-blind, placebo-controlled, phase 2b was conducted 21 medical institutions China from February November 2021. Totally 120 eligible patients were enrolled...
Abstract Background We isolated potential oral pathogens from IBD patients saliva and analyzed their virulence differences, hoping to elucidate the mechanism of different disease patterns in patients. Methods A series vitro vivo experiments, whole-genome sequencing, 16S rRNA sequencing non-targeted metabolomics were used explore pathogenicity Streptococcus mutans (S.m) isolates. Results Our previous study indicated that abundance streptococcus ulcerative colitis (UC) was higher than healthy...
Abstract Background The etiology of Inflammatory bowel disease (IBD) remains elusive, but emerging evidence suggests a potential link between oral microbiota and IBD. Porphyromonas gingivalis(Pg.), major pathogen in periodontal disease, its outer membrane vesicles(OMVs) may play significant roles the development progression Methods Animal models IBD were established to observe impact Pg. OMVs on intestinal inflammation. In vitro cell culture was conducted explore interaction Pg.-OMVs...
To the Editor: Biologics have been used successfully for treatment of psoriasis; however, some patients develop paradoxical reactions, particularly psoriasiform and eczematoid reactions. Eczematoid reactions (EPRs) occur in 1%–6% cases treated with tumor necrosis factor (TNF)-α inhibitors, 2.4% interleukin (IL)-12/23 3.5% IL-17 0.01% IL-23 inhibitors.[1] In practice, incidence EPRs induced by IL-17A inhibitors varies widely[2–4] biologicals may to be discontinued severe cases.[5] We...
Abstract: Background: Stapokibart has been approved for the treatment of adults with atopic dermatitis (AD) in China.
Abstract A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic delay. Although varieties of biomarkers have been investigated decades, and cancer antigen-125, antigen-199, interleukin-6, urocortin were most studied ones among hundreds biomarkers, no confirmed so far. Some emerging technologies including “omics” technologies, molecular imaging techniques, microRNAs are promising in solving these challenges, but their utility detect has yet be verified....
Abstract Atopic dermatitis (AD) is a common disease clinically characterized by chronic recurrent eczematous lesions, dry skin, and pruritus. AD can negatively impact patients’ quality of life. The prevalence in China has been increasing during the past few decades. Based on most recent advances treatment AD, we updated 2014 version Guidelines for Diagnosis Treatment Dermatitis regarding definition, epidemiology, pathogenesis, clinical classification, diagnosis, prevention, AD.
Abstract Background Management of moderate‐to‐severe atopic dermatitis (AD) needs long‐term therapy. Stapokibart is a humanized monoclonal antibody targeting interleukin‐4 receptor α subunit (IL‐4Rα), shared for IL‐4 and IL‐13 which are key pathogenic drivers AD. In pivotal phase 3 trial (NCT05265923), significant higher proportions adult AD patients receiving stapokibart than placebo achieved ≥75% improvement from baseline in Eczema Area Severity Index (EASI‐75; 66.9% vs. 25.8%)...
SUMMARY This study was undertaken to investigate the phenotypic and functional status of T lymphocytes human fetuses from early second- third-trimester. Cord blood samples were obtained 19 healthy (gestation weeks: 18–36), by cordocentesis, 16 term newborns weeks 37–42). Maternal unrelated male also taken as controls. Percentage in fetal white cells 79·3%, reducing 40% birth, much higher than that adults. mononuclear (CBMC), prepared density gradient centrifugation followed lysis...
There have been few real-life dose-comparing studies on the efficacy and safety of secukinumab in Chinese patients with plaque psoriasis. We conducted a cohort study to investigate 150 300 mg moderate-to-severe psoriasis.A total 106 psoriasis were included this study. Patients received either or according patients' weights severity The treatment continued for at least 24 weeks. was evaluated by improvement area index (PASI) scores. also analyzed.Fifty-nine (55.7%) treated 47 (44.3%) mg....
A hallmark of brain organization is the integration primary and modulatory pathways by principal neurons. However, pathway interactions that shape input processing remain unknown. We investigated this problem in mouse dorsal cochlear nucleus (DCN) where cells integrate primary, auditory nerve with modulatory, parallel fiber input. Using a combined experimental computational approach, we show LTP LTD inputs to DCN interneurons, respectively, broaden time window within which synaptic summate....