A5101674463- Receptor Mechanisms and Signaling
- Dermatology and Skin Diseases
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Computational Drug Discovery Methods
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
- Advanced biosensing and bioanalysis techniques
- Algal biology and biofuel production
- Proteoglycans and glycosaminoglycans research
- Asthma and respiratory diseases
- Light effects on plants
- Cytokine Signaling Pathways and Interactions
- Acne and Rosacea Treatments and Effects
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Molecular Sensors and Ion Detection
- Contact Dermatitis and Allergies
- Mycobacterium research and diagnosis
Tianjin University of Traditional Chinese Medicine
2015-2025
Shanghai University of Electric Power
2025
Ningbo First Hospital
2017-2025
Macao Polytechnic University
2025
University of Macau
2023-2024
First Hospital of China Medical University
2024
China Medical University
2024
Institute of Oceanology
2024
Chinese Academy of Sciences
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Significance How NK cell development diverges from T/B commitment at the common lymphoid progenitor stage is poorly understood. Histone modification near critical gene loci often influences lineage determination. Ezh2 a histone methyltransferase frequently associated with repression. Here we observed that Ezh2-null hematopoietic stem and cells (HSPCs) or HSPCs treated inhibitors gave rise to increased precursors mature progeny display enhanced cytotoxicity against tumor cells. The latter...
The net photosynthetic rate, chlorophyll content, fluorescence and 820 nm transmission were investigated to explore the behavior of apparatus, including light absorption, energy transformation photoactivities photosystem II (PSII) I (PSI) during senescence in stay-green inbred line maize (Zea mays) Q319 quick-leaf-senescence HZ4. relationship between performance decrease content two lines was also studied. Both field laboratory data indicated that PSII PSI decreased later slower than HZ4,...
Allosteric modulators of G protein-coupled receptors (GPCRs) have a number potential advantages compared to agonists or antagonists that bind the orthosteric site receptor. These include for receptor selectivity, maintenance temporal and spatial fidelity signaling in vivo, ceiling effect allosteric cooperativity which may prevent overdose issues, engendering bias by differentially modulating distinct pathways. Here we describe discovery, synthesis, molecular pharmacology δ-opioid...
DnaJ proteins, which are molecular chaperones that widely present in plants, can respond to various environmental stresses. At present, the function of proteins was studied many plant species, but only a few studies were conducted tomato. Here, we examined functions novel tomato (Solanum lycopersicum) protein (SlDnaJ20) heat tolerance using sense and antisense transgenic tomatoes. Transient conversion assays Arabidopsis protoplasts showed SlDnaJ20 targeted chloroplasts. Expression analysis...
Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks and interleukin-13 signaling. This trial aimed to evaluate the efficacy safety in Chinese with moderate-to-severe AD. Methods: multicenter, randomized, double-blind, placebo-controlled, phase 2b was conducted 21 medical institutions China from February November 2021. Totally 120 eligible patients were enrolled...
Abstract Background Xeligekimab (GR1501) is a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A and has shown potential efficacy in treating moderate-to-severe psoriasis preliminary trials. Objectives To evaluate the safety of xeligekimab Chinese patients with psoriasis. Methods A total 420 were randomized to 200 mg every 2 weeks (n = 281) or placebo 139) for first 12 weeks, followed by an extension treatment schedule 4 further 40 weeks. Efficacy was assessed...
Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. Aberrant metabolism, key hallmark of human cancers, plays crucial role in tumor progression, therapeutic responses and TNBC-related death. However, the underlying mechanisms are not fully understood. In this study, we delineate previously unrecognized aberrant glucose metabolism regulating turnover Snail1, which transcriptional factor epithelial-mesenchymal transition (EMT) critically contributes...
The objective of this study is to gain insight into the current research frontiers, hotspots, and development trends in field immunization programs for women children, provide scientific guidance reference follow-up research. Based on all original papers related children Web Science Core Collection (WoSCC) database, bibliometric studies visual analysis were carried out explore hotspots trends, analyze risk factors affecting vaccination coverage children. Eight hundred forty-three obtained...
The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established clinical trials, but there a lack multicenter data regarding its effectiveness real-world settings. Patients moderate-to-severe PN who initiated treatment between July 2023 January 2024, follow-up period at least 16 weeks 10 hospitals China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, dermatology life quality index...
As an organic material with a high hydrogen storage density, formic acid is liquid carrier broad research prospects. Designing highly efficient and selective dehydrogenation catalysts key to realizing the application of dehydrogenation. In this article, ultrafine Pd particles were attached aminated mesoporous SiC using impregnation chemical reduction methods, providing large number active sites for dissociation HCOO*. Compared α-SiC, β-SiC performs better in Pd@β-SiC(APTES + CIT) exhibits...
Atopic dermatitis (AD) is a chronic inflammatory skin disease. 611, humanized monoclonal antibody, selectively targets the interleukin (IL)-4 receptor alpha, thereby inhibiting signaling of both and IL-13. This phase 2 study aimed to evaluate efficacy safety 611 in Chinese adults with moderate-to-severe AD. randomized, double-blind, placebo-controlled was conducted between October 2022 September 2023. Eligible patients AD were randomly assigned 1:1:1 ratio receive at dose either 300 mg...
Abstract: Background: Stapokibart has been approved for the treatment of adults with atopic dermatitis (AD) in China.
Resistance to BRAF inhibitors (BRAFi) is one of the major challenges for targeted therapies BRAF-mutant melanomas. However, little known about role microRNAs in conferring BRAFi resistance. Herein, we demonstrate that miR-200c expression significantly reduced whereas target genes including Bmi1, Zeb2, Tubb3, ABCG5, and MDR1 are increased melanomas acquired resistance compared pretreatment tumor biopsies. Similar changes were observed BRAFi-resistant melanoma cell lines. Overexpression or...