A5100357442- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Photodynamic Therapy Research Studies
- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Nonmelanoma Skin Cancer Studies
- Oral Health Pathology and Treatment
- Autoimmune and Inflammatory Disorders
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Lymphoma Diagnosis and Treatment
- Risk and Safety Analysis
- Medicine, History, and Philosophy
- Histiocytic Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Colorectal and Anal Carcinomas
- Skin and Cellular Biology Research
- Skin Diseases and Diabetes
- Visual Attention and Saliency Detection
- Peripheral Neuropathies and Disorders
- Asthma and respiratory diseases
- Acupuncture Treatment Research Studies
- Viral-associated cancers and disorders
Chinese PLA General Hospital
2015-2025
Shaoxing University
2025
Creative Commons
2023
Beijing Children’s Hospital
2023
Capital Medical University
2023
Weatherford College
2023
First Affiliated Hospital of GuangXi Medical University
2022
Guangxi Medical University
2022
Chinese People's Liberation Army
2015
Xijing Hospital
2009-2012
The mechanism linking psoriasis to metabolic syndrome (MetS) remains poorly understood. Recent reports indicate upregulation of glycolysis-related proteins in psoriatic keratinocytes (KCs). However, the role glucose metabolism reprogramming KCs, psoriasis, and with MetS unclear. In this study, we confirmed KCs by examining genes, proteins, metabolites. We found that inhibiting psoriasiform led improvements features. Notably, observed enhanced within skin lesions patients MetS. vitro,...
Abstract Background Xeligekimab (GR1501) is a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A and has shown potential efficacy in treating moderate-to-severe psoriasis preliminary trials. Objectives To evaluate the safety of xeligekimab Chinese patients with psoriasis. Methods A total 420 were randomized to 200 mg every 2 weeks (n = 281) or placebo 139) for first 12 weeks, followed by an extension treatment schedule 4 further 40 weeks. Efficacy was assessed...
Deep learning has the potential to improve diagnostic accuracy and efficiency in medical image recognition. In current study, we developed a deep algorithm assessed its performance discriminating melanoma from nevus using whole-slide pathological images (WSIs). The was trained validated set of 781 WSIs (86 melanomas, 695 nevi) PLA General Hospital. tested on an independent test 104 (29 75 Tianjin Chang Zheng same also diagnostically classified by 7 expert dermatopathologists. receiver...
To explore the risk factors for malnutrition in patients with ulcerative colitis complicated pyoderma gangrenosum and establish a nutritional prediction model these patients. A total of 277 treated from 2019 to 2024 were divided into group (n=185) normal nutrition (n=92) according whether occurred. The data 25 potential related pertaining general demography, living eating habits, disease-related compared between two groups. Lasso regression was used screen factors, nomogram established based...
Background: Psoriasis is a chronic inflammatory skin disease that has no cure.While the specific cause of psoriasis unknown, interactions between immune cells and cytokines are believed to be important in its pathogenesis.Thymic stromal lymphopoietin (TSLP) cytokine produced by epithelial profoundly affects dendritic (DCs) involved allergy diseases.In some studies, expression higher patients, whereas it increased treated patients when compared with untreated others. Aims:To investigate role...
Objective: To investigate the factors influencing pharmacokinetics of mycophenolate mofetil (MMF) in pediatric patients after liver transplantation, and to establish a population model, which can provide reference for clinical dosage adjustment. Methods: A prospective study single center was performed on who were administrated with dispersible tablets (MMFdt) at least 4 days transplantation continuously. Blood samples collected ethylene diamine tetraacetic acid anticoagulant tubes before...
Abstract Lymphomatoid papulosis (LyP) type E is a recently described variant characterized by the occurrence of large necrotic eschar‐like lesions displaying microscopically angioinvasive and angiodestructive infiltrates CD30+ lymphocytes, frequently coexpressing CD8. Rare cases LyP with CD56+ immunophenotype have been described. Herein, we describe 36‐year‐old woman E, purpura‐like on her left ankle. Initially, she presented ankle swelling, petechiae ecchymosis, rapidly developing papules,...
We report a case of 7-year-old male patient with vaccine-induced erythrodermic psoriasis (EP) complicated by pulmonary infection, hypoproteinemia, and liver dysfunction successfully treated secukinumab in combination symptomatic supportive therapy. The presented diffuse flushing on the head, face, trunk, limbs, which were covered chaff-like white scales rash-affected area, no blisters, pustules, apparent abnormalities palms, soles, nails, joints. Histopathology analysis revealed...
Background and Objectives Alopecia areata (AA) is an autoimmune disease characterized by T cell‐mediated attack on the hair follicle. Although there are a wide range of therapies, majority them not satisfactory due to side effects or limited efficacy. In this study, we sought evaluate efficacy, influence factors, safety 308‐nm excimer lamp with minoxidil in treatment AA. Study Design/Materials Methods This was prospective, single‐blinded, self‐control using for One selected alopecia lesion...
The histopathological characteristics of lymphomatoid papulosis (LyP) vary. Currently, 6 subtypes have been reported, including a new subtype with perifollicular infiltration and different degrees folliculotropism CD30+ atypical lymphocytes, known as follicular LyP. However, LyP pathologically manifesting folliculotropism, eccrinotropism neurotropism has rarely reported. We present case showing lymphocytes around the hair follicle, eccrine gland nerve fiber, varying infiltrates. pathological...
To observe the effect of acupotomy on fat infiltration degree lumbar multifidus muscle (LMM) in patients with disc herniation after percutaneous transforaminal endoscopic discectomy (PTED).A total 104 treated PTED were randomly divided into an observation group (52 cases, 3 cases dropped off) and a control 4 off). Patients both groups received rehabilitation training two weeks 48 h treatment. The was (L3-L5 Jiaji [EX-B 2]) once within 24 PTED. In groups, cross sectional area (CSA) LMM...
Pilar sheath acanthoma is a rare, benign follicular hamartoma. Mehregan and Brownstein fist reported this solitary, asymptomatic, skin-colored nodule with central pore-like opening in 1978. The classic location for these lesions the upper lip of elderly patients. Here we report an interesting case pilar presenting on left eyebrow middle-aged female. To our knowledge, first such unique location.
Inflammatory pseudotumour (IP) is a rare proliferative disease characterized by dense infiltrate of plasma cells, lymphocytes, eosinophils and neutrophils in the fibrous stroma. It primarily affects lungs pediatric patients or young adults. Cutaneous IP an extremely condition, with limited documentation English literature. In this case report, we presented unusual instance 62-year-old male endured recalcitrant cutaneous for 8 years exhibited poor response to topical glucocorticoid therapy,...
Psoriasis is a chronic and recurrent skin disease characterized by aberrant proliferation differentiation of keratinocyte cells. Although calcipotriol has been employed in the clinical management psoriasis, no association between anti-inflammatory mechanism iron death reported. Therefore, we assume that may down-regulate cell activity suppress expression tissue inflammatory factors regulating glutathione (GSH) peroxidase 4 (GPX4) pathway, thereby alleviating inflammation ameliorating...
Early fault detection and timely maintenance scheduling can significantly mitigate operational risks in NPPs enhance the reliability of operator decision-making. Therefore, it is necessary to develop an efficient Prognostics Health Management (PHM) multi-step prediction model for predicting system health status prompt execution operations. In this study, we propose a novel predictive that integrates reinforcement learning with Long Short-Term Memory (LSTM) neural networks Expert Fuzzy...