A5101821966- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Advanced Sensor and Energy Harvesting Materials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related gene regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- PI3K/AKT/mTOR signaling in cancer
- Congenital Heart Disease Studies
- Dermatological and Skeletal Disorders
- Pancreatic function and diabetes
- Hedgehog Signaling Pathway Studies
- Management of metastatic bone disease
- Nanofabrication and Lithography Techniques
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Genetic and Kidney Cyst Diseases
- Urban Heat Island Mitigation
- Optical properties and cooling technologies in crystalline materials
- Nanomaterials and Printing Technologies
- NF-κB Signaling Pathways
- Dermatologic Treatments and Research
University of Chinese Academy of Sciences
2024
National Center for Nanoscience and Technology
2023
Chinese Academy of Sciences
2022-2023
Chinese PLA General Hospital
2015-2022
Chinese People's Liberation Army
2022
Air Force Medical University
2013-2022
Xijing Hospital
2022
Technical Institute of Physics and Chemistry
2022
Abstract Passive radiative cooling is a promising technology for heat dissipation that does not consume energy. However, current materials can only exhibit subambient under atmospheric conditions and struggle to process specific accumulation. Thus, passive thermal regulation mechanism adapted wide‐temperature‐range applications required match device heating systems. Herein, heteroporous nanocomposite film (HENF) with thermo‐adaptive radiation performance reported. Compared conventional...
// Bing Wu 1,* , Lu Yu 2,* Yishi Wang 3,* Hongtao Chen Li 3 Yue Yin 3,4 Jingrun Yang Zhifa Qiangsun Zheng 1 and Heng Ma Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China 2 Pathology, Xijing Physiology, School Basic medicine, 4 Pathophysiology, * These authors have contributed equally to this work Correspondence to: Ma, email: Zheng, Keywords : aging, ALDH2, autophagy, carbonyl stress, SIRT1, Gerotarget Received September 10, 2015 Accepted December...
Halide double perovskites present a new branch for versatile optoelectronic devices because of their huge structural compatibility and environmental friendliness, whereas nonlinear optics (NLO) remain blank this fascinating family. Simultaneously, the precise patterning single-crystalline perovskite microwire arrays remains challenge integration NLO devices. Herein, we designed lead-free chiral 2D with nonsymmetrical structure presenting second-harmonic generation (SHG). Furthermore,...
Deep learning has the potential to improve diagnostic accuracy and efficiency in medical image recognition. In current study, we developed a deep algorithm assessed its performance discriminating melanoma from nevus using whole-slide pathological images (WSIs). The was trained validated set of 781 WSIs (86 melanomas, 695 nevi) PLA General Hospital. tested on an independent test 104 (29 75 Tianjin Chang Zheng same also diagnostically classified by 7 expert dermatopathologists. receiver...
Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal responses. Metformin the first‐line drug in type 2 diabetes has been proven to possess significant anti‐inflammatory effects various diseases. In present study, we examined role metformin nuclear factor kappa B (NF‐κB)–mediated responses HaCaT cells, cell line for keratinocyte. Our results demonstrated significantly decreased mRNA protein levels tumour...
Clinical observations have demonstrated a link between chronic pain and increased ischemic heart disease mortality, but the mechanisms remain elusive.Reactive aldehydes recently been confirmed as new player in pathologies, while our previous study that reactive (4-HNE) induced carbonyl stress contributing to myocardial intolerance.The aim of this was explore whether increases susceptibility ischemia/reperfusion (MI/R) injury investigate underlying focusing on toxic aldehyde stress.Methods:...
Metastatic skin cutaneous melanoma (SKCM) is a common malignancy that accounts for low morbidity but high mortality of cancer. SKCM characterized by lymphocytic infiltration, whereas the states infiltrated cells are variable in patients leading to heterogeneous prognosis and hindering appropriate clinical decisions. It therefore urgent identify markers associated with cellular conditions, SKCM. In this study, we report CEBPB, transcriptional factor, mainly expressed macrophages metastatic an...
Accidental deaths due to exposure extremely low natural temperature happen every winter.Exposure extreme cold causes injury of multiple organs.However, early responses the bodies acute remain incompletely understood.In this study, we found that hepatic glycogen was rapidly reduced in rats exposed -15°C, and key enzymes required for glycogenesis were upregulated livers cold-exposed rats.In line with rapid consumption glycogen, induced a transient elevation cellular ATP level, which lasted...
Global efforts have been undertaken to define the genome-wide distribution of epigenetic markers in cancerous tissues, which provide an invaluable opportunity understand cancer biology and identify predictive signatures. Several studies focused on gene expression patterns squamous carcinoma tumor subtypes find prognostic therapeutic targets because genomes showed high instability. However, number reliable reports referring significance genes their role is still quite limited. Krüppel-like...
Abstract Lymphomatoid papulosis (LyP) type E is a recently described variant characterized by the occurrence of large necrotic eschar‐like lesions displaying microscopically angioinvasive and angiodestructive infiltrates CD30+ lymphocytes, frequently coexpressing CD8. Rare cases LyP with CD56+ immunophenotype have been described. Herein, we describe 36‐year‐old woman E, purpura‐like on her left ankle. Initially, she presented ankle swelling, petechiae ecchymosis, rapidly developing papules,...
Patterning organic semiconductors directly on Au electrodes possesses the advantages of eliminating metal atomic penetration effect, compatibility with fine lithography processes, and feasibility work function modification electrodes, it is therefore value in commercial manufacturability application optoelectronic devices low cost, large scale, high efficiency. Solution processing, relatively inexpensive scalable to areas. Nonetheless, conventional solution processing approaches have...
An integration technique has been developed to assemble the π-conjugated polymer/SWCNT composite materials into 1D arrays by exploiting an asymmetric-wettability assembly system, realizing enhanced charge-carrier mobility and thermal stability.
<h3>Objective</h3> Plasma microRNAs (miRNAs) have been recently reported to be sensitive and specific biomarkers of various tissue injuries pathological conditions. MiR-126 plays an important role in maintaining endothelial cell homeostasis vascular integrity. The goal this study was assess whether is good tool for the prognostication hypertension. <h3>Methods</h3> plasma concentrations miR-126and miR-499 were assessed among patients with pre-hypertension hypertensionby a real-time reverse...
Pain is not a symptom that exists alone, but whether chronic pain enhances susceptibility to myocardial ischemia/reperfusion (MI/R) injury and the underlying mechanisms remain unknown. Reactive aldehydes contribute pathologies cardiac injury, suggesting aldehyde dehydrogenase (ALDH2), which detoxifies aldehydes, may regulate related MI/R injury. In this study, neuropathic was induced by compression of dorsal root ganglion (CCD). CCD for 2 weeks, ALDH2 KO or wild-type (WT) littermates were...
Objective To evaluate the effect of metformin on human keratinocyte line HaCaT, and to explore its molecular mechanism. Methods HaCaT cells were divided into several groups be treated with at different concentrations 1, 2, 5, 10, 20, 50 mmol/L for 24, 48 72 hours. Cell counting kit-8 (CCK-8) assay was performed survival rate HaCaT cells. After 48-hour treatment 0 (control group) , 0.5, 10 mmol/L, flow cytometry conducted cell cycle apoptosis. Western blot analysis determine expression...
Primary cilium has attracted increasing attention in the biomedical field recent years. It exists surface of various cells and is micro-sized, but its complex structures have not been clear. The primary an important role sensory perception. Cells can receive extracellular mechanical chemical signals through cilia, cilia assist transferring into cells, followed by cellular responses. Recent studies shown that also plays embryonic development malignant transformation cells. investigation will...