A5073221601- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Brain Metastases and Treatment
- Effects of Radiation Exposure
- Management of metastatic bone disease
- Advanced MRI Techniques and Applications
- Lung Cancer Treatments and Mutations
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Digital Radiography and Breast Imaging
- Head and Neck Surgical Oncology
- Glutathione Transferases and Polymorphisms
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Educational Technology and Assessment
- Radiation Shielding Materials Analysis
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
People's Liberation Army No. 150 Hospital
2021-2024
Beihang University
2015-2024
Peking Union Medical College Hospital
2024
Cancer Hospital of Chinese Academy of Medical Sciences
2023-2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Chinese PLA General Hospital
2014-2023
National Clinical Research
2023
Medical College of Wisconsin
2015-2016
Abstract Purpose To study the performance of MapCHECK 3 (MC3) in measuring universal wedge fields and propose a dose rate correction strategy to improve MC3 measurement accuracy. Materials methods Universal with different angles field sizes were measured at depths using MC3. Considering more prominent dependence type 4 diodes equipped by MC3, program was developed automatically correct measurements based on instantaneous (IDR) curve. Central axis (CAX) doses off‐axis along direction, without...
This study focused on predicting 3D dose distribution at high precision and generated the prediction methods for nasopharyngeal carcinoma patients (NPC) treated with Tomotherapy based patient-specific gap between organs risk (OARs) planning target volumes (PTVs).A convolutional neural network (CNN) is trained using CT contour masks as input distributions output. The CNN "3D Dense-U-Net", which combines U-Net Dense-Net. To evaluate model, we retrospectively used 124 NPC Tomotherapy, in 96 28...
The use of Intensity-modulated radiotherapy (IMRT) and Helical tomotherapy (HT) is increasing in gynecological cancer patients. No published studies have performed a dosimetric evaluation whole pelvic (WPRT) using HT for postoperative endometrial cancer. purpose this study was to perform direct comparison three-dimensional conformal (3D-CRT), IMRT plans WPRT patients, evaluate the integral dose organs at risk (OARs) normal tissue.We selected ten patients with undergoing WPRT. Plans 3D-CRT,...
The goal of this study was to evaluate real-time volumetric and dosimetric changes the parotid gland so as determine replanning criteria timing for protection-based adaptive radiation therapy in nasopharyngeal carcinoma. Fifty NPC patients were treated with helical tomotherapy; (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>D</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">m</mml:mi><mml:mi...
Abstract Purpose To investigate the dose rate dependence of MapCHECK3 and its influence on measurement accuracy, as well effect correction. Materials methods The average instantaneous MapCHECK2 were studied. accuracy measurements was investigated where differed significantly between calibration MapCHECK measurement. Measurements include: central axis for different fields at depths, off‐axis doses outside field, along wedge direction. using an ion chamber taken reference. Exponential...
During the radiation treatment planning process, one of time-consuming procedures is final high-resolution dose calculation, which obstacles wide application emerging online adaptive radiotherapy techniques (OLART). There an urgent desire for highly accurate and efficient calculation methods. This study aims to develop a super resolution-based deep learning model fast prediction in clinical practice. A Multi-stage Dose Super-Resolution Network (MDSR Net) architecture with sparse masks module...
To evaluate the outcomes of nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy (HT).Between September 2007 and August 2012, 190 newly diagnosed NPC were HT. Thirty-one radiation therapy as single modality, 129 additional cisplatin-based chemotherapy or without anti-EGFR monoclonal antibody therapy, 30 concurrent therapy.Acute related side effects mainly grade 1 2. Grade 3 greater toxicities rarely noted. The median followup was 32 (3-38) months. local relapse-free...
The goal of this study was to evaluate the actual anatomical and dosimetric changes parotid glands in nasopharyngeal carcinoma patients during intensity modulated radiation therapy. With helical tomotherapy, its planning system, adaptive software, weekly 35 NPC were evaluated. Interweekly volume varied significantly (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.03</mml:mn></mml:math>). rate change reached highest level at...
Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) candidate genes from these can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between SNPs risk RP. Methods: We recruited total 149 lung cancer patients who had received intensity modulated therapy (IMRT). GSTP1...
Objective This study aimed to develop a least absolute shrinkage and selection operator (LASSO)-based multivariable normal tissue complication probability (NTCP) model predict radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC) treated comprehensive salivary gland–sparing helical tomotherapy technique. Methods Materials LASSO the extended bootstrapping technique was used build NTCP models factors of patient-reported relieved by 50% 80% compared level at end radiation...
The purpose of this study was to evaluate and explore the difference between an atlas-based deep learning (DL)-based auto-segmentation scheme for organs at risk (OARs) nasopharyngeal carcinoma cases provide valuable help clinical practice.120 were established in MIM Maestro (atlas) database trained by a DL-based model (AccuContour®), another 20 randomly selected outside atlas database. experienced physicians contoured 14 OARs from patients based on published consensus guidelines, these...
Abstract Background Due to inconsistent positioning, tumor shrinking, and weight loss during fractionated treatment, the initial plan was no longer appropriate after a few fractional treatments, patient will require adaptive helical tomotherapy (HT) overcome issue. Patients are scanned with megavoltage computed tomography (MVCT) before each which is utilized for setup provides information dose reconstruction. However, low contrast high noise of MVCT make it challenging delineate treatment...
To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation (CSI) using helical tomotherapy (HT) system in our center.Twenty-three who were CSI center from January 2008 to July 2012 collected, an average age 20. All patients' used HT system. The total doses 27-36 Gy/15-20 F (1.5-2 Gy per fraction), and local 46-60 Gy/30-50 (5 fractions week). female for left-right parallel-opposed field protect their ovarian functions. Median...
The aim of the study was to evaluate short-term safety and efficacy simultaneous modulated accelerated radiation therapy (SMART) delivered via helical tomotherapy in patients with nasopharyngeal carcinoma (NPC).Between August 2011 September 2013, 132 newly diagnosed NPC were enrolled for a prospective phase II study. prescription doses gross tumor volume (pGTVnx) positive lymph nodes (pGTVnd), high risk planning target (PTV1), low (PTV2), 67.5 Gy (2.25 Gy/F), 60 (2.0 54 (1.8 30 fractions,...
Purpose: Radiation pneumonitis (RP) is the most significant dose-limiting toxicity and one major obstacle for lung cancer radiotherapy.Grade ≥2 RP usually needs clinical interventions serve could be life threatening.Clinically, tissue response strikingly different even two similar patients after identical radiotherapy.Previous methods prediction can hardly distinguish substantial variations among individuals.Reliable predictive factors or emphasizing individual differences are strongly...
Consistent training and testing datasets can lead to good performance for deep learning (DL) models. However, a large high-quality dataset unusual clinical scenarios is usually not easy collect. The work aims find optimal data collection strategies DL-based dose prediction models.A total of 325 clinically approved cervical IMRT plans were utilized. We designed comparison experiments investigate the impact (1) beam angles, (2) number beams, (3) patient position DL In addition, novel...