A5043878079- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant-based Medicinal Research
- Brain Metastases and Treatment
- Circular RNAs in diseases
- Ion channel regulation and function
- Advanced Radiotherapy Techniques
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Traditional Chinese Medicine Analysis
- Forensic Toxicology and Drug Analysis
- Neurogenesis and neuroplasticity mechanisms
- Glutathione Transferases and Polymorphisms
Capital Medical University
2012-2025
Shanghai University of Medicine and Health Sciences
2021-2025
Anhui University of Science and Technology
2022-2024
Huazhong University of Science and Technology
2016-2024
Sun Yat-sen University
2016-2024
State Key Laboratory of Medical Neurobiology
2021-2024
Fudan University
2021-2024
Nanjing University of Chinese Medicine
2024
Shanghai Stomatological Hospital
2024
Changchun Institute of Optics, Fine Mechanics and Physics
2023-2024
Membrane proteins are a crucial class of therapeutic targets that remain challenging to modulate using traditional occupancy-driven inhibition strategies or current proteolysis-targeting degradation approaches. Here, we report the inherent endolysosomal sorting machinery can be harnessed for targeted membrane proteins. A new technique, termed signal-mediated lysosome-targeting chimeras (SignalTACs), was developed by genetically fusing signaling motif from cation-independent...
Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets cellular mRNAs. Depletion PCBP1 implicated in various carcinomas, but the underlying mechanism tumorigenesis remains elusive. We performed a transcriptome-wide screen to identify novel bounding mRNA PCBP1. The bind regions between with target were investigated by using point mutation luciferase assay. Cell proliferation, cell cycle, apoptosis also evaluated ovary colon cancer...
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism not fully understood yet. Here, we find that TMC6, a membrane protein unknown function, highly expressed in dorsal root ganglion (DRG) neurons functions as Gαq-coupled G protein-coupled receptor (GPCR)-like to sense noxious heat. TMC6-deficient mice display substantial impairment heat sensation while maintaining normal perception cold, warmth, touch, mechanical pain. Further studies show...
A GaN-based ultraviolet bipolar phototransistor with high zero-bias gain is obtained based on an asymmetric n–p–i–n homo-structure. thin-base structure proposed to suppress excess holes recombination and, thus, promote optical gain.
ABSTRACT Objective Ischemia–reperfusion of the abdominal aorta often results in damage to distant organs, such as heart and brain. This cellular heterogeneity within affected tissues complicates roles specific cell subsets occlusion model (AAO) injury. However, type–specific molecular pathology hippocampus after ischemia is poorly understood. Aims In this study, we adopted a mouse AAO investigate single‐cell transcriptome hippocampi mice. Methods Male C57BL/6 mice (8 weeks old) were used...
Cognitive decline is a chronic condition which characterized by loss of the ability to remember, learn, and pay attention complex tasks. Many older people are now suffering from cognitive decline, decreases life quality leads disability. This study aimed identify risk protective factors for daily establish predictive model using logistic regression. We investigated 3,790 with health examination questionnaires included information associated physical condition, lifestyle factors, status....
Abstract: BACKGROUND: Thoracic aortic ischemia-reperfusion (I/R) injury occurs in clinical scenarios and can lead to damage organs such as the spinal cord, kidneys, intestines. Hypoxic postconditioning (HyP) has shown promise reducing organ I/R injury, suggesting its potential applicability thoracic injury. However, pathological caused by aorta occlusion (TAO) heart brain is not yet well understood. This study aims investigate protective effects of hypoxic conditioning treatment on cardiac...
Enterovirus 71 (EV71) is the major pathogen of hand, foot, and mouth disease can cause death; however, its pathogenesis remains elusive.We performed a detailed systematic histopathologic examination molecular studies on six autopsy cases EV71 infection using H&E, immunohistochemistry, double immunofluorescence staining, nested reverse transcription polymerase chain reaction.Characteristic features acute encephalomyelitis were observed. Viral antigens mainly detected in neuronal cytoplasm...
Liver metastasis (LM) remains a major cause of cancer-related death in patients with pancreatic cancer (PC) and is associated poor prognosis. Therefore, identifying the risk prognostic factors PC LM (PCLM) essential as it may aid providing timely medical interventions to improve prognosis these patients. However, there are limited data on PCLM patients.To investigate develop corresponding diagnostic nomograms.Patients primary diagnosed between 2010 2015 were reviewed from Surveillance,...
Objective. This study aimed to analyze the effects of comprehensive protection bilateral parotid glands (PG-T), contralateral submandibular gland (cSMG), and accessory salivary in oral cavity (OC) by helical tomotherapy for head-and-neck cancer patients. Methods . Totally 175 patients with histologically confirmed treated were recruited. The doses delivered PG-T, cSMG, OC constrained be as low possible treatment planning. saliva flow rates xerostomia questionnaire evaluated. Correlation...
Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency treatment of the neuroma at axotomized nerve stump effectively relieves phantom afflicting patients after amputation. This indicated an essential role residual in formation chronic post-amputation (CPAP). However, molecular mechanism by which is involved and regulates CPAP a mystery. In this...
Suppressor of cytokine signaling 1 (SOCS1) participates in renal fibrosis by downregulating Janus kinase 2 (JAK2)/signal transducer and activator transcription (STAT1)-mediated signaling. Recently, it was found that anti-double-stranded DNA (dsDNA) IgG induces the synthesis profibrotic cytokines cells. To explore potential effect anti-dsDNA on SOCS1-mediated fibrosis, kidney tissues were collected from patients with lupus nephritis (LN) as well MRL/lpr lupus-prone mice. The SOCS1 expression...
Background Few studies were reported on the comparison of clinical outcomes between intensity-modulated radiotherapy (IMRT) and three-dimensional conformal (3D-CRT) in treatment glioblastoma multiforme (GBM). This study aimed to determine whether IMRT improves compared with 3D-CRT patients GBM. Methods The records 54 newly-diagnosed GBM from July 2009 December 2010 reviewed. underwent postoperative or concurrent adjuvant temozolomide. Kaplan-Meier method log rank test used estimate...
Terbufos (TBF) is a class Ia (extremely hazardous) organophosphate pesticide (OP) and its distribution in industrialized countries has been severely restricted. Thus, acute occupational poisoning rather uncommon. However, it still occurs rural areas of some developing countries, where the sale TBF not controlled use thus properly regulated. We report case 43-year-old female farmer who died after applying granules.The patient within 3 h 20 bags 5% granules (900 g per bag). Investigation...
Abstract Traumatic axonal injury (TAI) is one of the most common pathological features severe traumatic brain (TBI). Our previous study using proteomics suggested that peripherin (PRPH) should be a potential candidate as biomarker for TAI diagnosis. This to further elucidate role and association PRPH with TAI. In animal study, we performed immunohistochemistry, ELISA morphological analysis evaluate level distribution following impact. PRPH‐positive regions were widely distributed in tract...
Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) candidate genes from these can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between SNPs risk RP. Methods: We recruited total 149 lung cancer patients who had received intensity modulated therapy (IMRT). GSTP1...
Abstract Deinagkistrodon acutus ( D . ), also known as the Chinese moccasin, is a viper species found throughout southeastern parts of China, northern Vietnam and Laos. envenomation can result in coagulopathy lead to death if not treated correctly. A 20‐year‐old man was discovered with severely swollen left thigh overlying dark purple, discolored skin. He immediately transported hospital. Laboratory examinations revealed dysfunctional coagulation fluid‐electrolyte imbalances. died 2 h later...