A5029355578- RNA modifications and cancer
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Liver physiology and pathology
- Monoclonal and Polyclonal Antibodies Research
- Diagnosis and treatment of tuberculosis
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury Research
- Calcium signaling and nucleotide metabolism
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Cancer, Stress, Anesthesia, and Immune Response
- Natural product bioactivities and synthesis
- Mycotoxins in Agriculture and Food
- Cellular Mechanics and Interactions
- Adenosine and Purinergic Signaling
- HIV/AIDS drug development and treatment
- Fungal Biology and Applications
- Medical Imaging and Analysis
- Acute Kidney Injury Research
- Protein Degradation and Inhibitors
First Affiliated Hospital Zhejiang University
2022-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Shanghai Jiao Tong University
2024
Zhejiang University
2020-2023
Sun Yat-sen University
2015-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Liaocheng People's Hospital
2020
Abstract Long noncoding RNAs (lncRNAs) play multiple key regulatory roles in various cellular pathways. However, their functions HIV-1 latent infection remain largely unknown. Here we show that a lncRNA named NRON, which is highly expressed resting CD4 + T lymphocytes, could be involved latency by specifically inducing Tat protein degradation. Our results suggest NRON potently suppresses the viral transcription decreasing abundance of transactivator Tat. directly links to...
Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets cellular mRNAs. Depletion PCBP1 implicated in various carcinomas, but the underlying mechanism tumorigenesis remains elusive. We performed a transcriptome-wide screen to identify novel bounding mRNA PCBP1. The bind regions between with target were investigated by using point mutation luciferase assay. Cell proliferation, cell cycle, apoptosis also evaluated ovary colon cancer...
Acquired chemotherapy resistance is one of the main culprits in relapse breast cancer. But underlying mechanism remains elusive. Here, we demonstrate that a small adaptor protein, SH3BGRL, not only elevated majority cancer patients but also has relevance with and poor prognosis patients. Functionally, SH3BGRL upregulation enhances chemoresistance cells to first-line doxorubicin treatment through macroautophagic/autophagic protection. Mechanistically, can unexpectedly bind ribosomal subunits...
Abstract Background HER2-positive breast cancer is usually associated to the more aggressive progression and worse prognosis, but mechanism underlying innate resistance HER2-targeted therapy remains elusive. The scaffold protein SH3-domain-binding glutamic acid-rich protein-like (SH3BGRL) indicated as a tumor suppressor in some cancers, it highly expressed cancers. Here we characterized tumorigenic function of SH3BGRL HER2-expressing cells subsequent effect therapies. Methods interaction...
Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies, resulting in severe disability. Macrophages are widely recognized as trigger during peritendinous formation. However, different clusters macrophages have various functions and receive multiple regulation, which both still unknown. In our current study, multi-omics analysis including single-cell RNA sequencing proteomics was performed on...
Accumulating evidence show that Poly C Binding Protein 1 (PCBP1) is deleted in distinct types of tumors as a novel tumor suppressor, but its suppression mechanism remains elusive. Here, we firstly describe downregulation PCBP1 significantly associated with clinical ovarian progression. Mechanistically, overexpression affects various autophagy-related genes expression at levels to attenuate the intrinsic cell autophagy, including autophagy-initiating ULK, ATG12, ATG7 well bona fide marker...
Inflammation is a key regulator in the progression of atherosclerosis (AS) which extremely affects people’s health. Secoisolariciresinol diglucoside (SDG), plant lignan, relevant to angiogenesis and cardioprotection against ischemia-reperfusion injury improves vascular disorders. However, effect SDG on cardiovascular disorder not clear. In present study, we aimed investigate effects lipopolysaccharide- (LPS-) stimulated Human Umbilical Vein Endothelial Cells (HUVECs) elucidate underlying...
Septic shock is one of the leading causes mortality in intensive care units. This retrospective study was carried out to evaluate association clinical available factors with 28-day mortality.In this observational study, patients perioperative septic shocks secondary intra-abdominal infection caused by enteric perforation were included. A total 328 sepsis admitted surgical units from January 2012 December 2016. 138 met enrolment criteria and included study. The data demographic, laboratory...
Sepsis is one of the leading causes mortality in intensive care units (ICU). The growing incidence rate sepsis and its high result are very important sociosanitary problems. a infection which can cause systemic inflammatory organ failure. But pathogenesis molecular mechanisms still not well understood. aim present study was to identify candidate key genes progression sepsis.Microarray datasets GSE28750, GSE64457, GSE95233 were downloaded from Gene Expression Omnibus (GEO) database....
AimsRetinal ischemia/reperfusion (I/R) injury is implicated in the etiology of various ocular disorders. Prior research has demonstrated that bone marrow tyrosine kinase on chromosome X (BMX) contributes to advancement ischemic disease and inflammatory reactions. Consequently, current investigation aims evaluate BMX's impact retinal I/R clarify its implied mechanism action.Main methodsThis study utilized male female systemic BMX knockout (BMX−/−) mice conduct experiments. The utilization...
<title>Abstract</title> <bold>(1)Background:</bold> Patients with severe brain injuries who are bedridden for extended periods often exhibit diminished voluntary movements. This reduction can compromise the precision of CRS-R evaluations. The Arousal Facilitation Protocol (AFP)is designed to extend duration patient arousal through deep muscle pressure. Conversely, Neural Mobilization (NM) seeks augment nerve activity post-brain injury and encourages resurgence study aims identify effective...
Cerebral aspergillosis (CA) is a rare manifestation of invasive aspergillosis. It usually affects seriously immunocompromised hosts. Pancreatic bacterial or/and fungal infection common in patients with severe acute pancreatitis.We report the first case an immunocompetent woman infected necrotizing pancreatitis due to multidrug resistant Acinetobacter baumannii who, course treatment, developed isolated CA.Magnetic resonance imaging, rather than computed tomography, revealed latent homolateral...
Abstract Here we report two patients with a car accident injury who suffered cerebral infarction following missed diagnosis of blunt cerebrovascular injury. Difficulty in these cases because no neurological signs or symptoms on initial assessment is lesson for physicians from emergency room. Our conclusion upon dealing the situation that traumatic has potentially devastating consequences. There often delay between trauma and onset deficit. Therefore, clinicians should be cautious this...
Objective To investigate the diagnostic value of three imaging examination methods (MRI, CT and X-ray) in diagnosis spinal tuberculosis lesion. Methods A retrospective analysis clinical data was carried out 50 patients with complete from February 2013 to June 2015. The performance X-ray, MRI were observed, compared. Results The accuracy rate, sensitivity, specificity 72.65%, 68.88%, 72.33%, 86.39%, 79.69%, 90.25%, which significantly higher than those CT, there significant...
Objective To investigate the protective effect of neurotensins on inflammatory responses in mice with LPS-induced acute lung injury. Methods 100 specific-pathogen free C57BL/6 (20-25 g, 6-8 weeks, 50 males and females) were obtained from Shanghai Laboratory Animal Center (SLAC) (Shanghai, China). All animals randomly divided into five groups:① Normal control group: treated 60 μl PBS intratracheally;② injury μg LPS intratracheally;③ 20 mg/kg ALI subjected to Nts via tail vein injection...