A5100381695- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- interferon and immune responses
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Protein Tyrosine Phosphatases
- Nuclear Engineering Thermal-Hydraulics
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Retinoids in leukemia and cellular processes
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Histone Deacetylase Inhibitors Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Combustion and Detonation Processes
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Diet, Metabolism, and Disease
- Protein Kinase Regulation and GTPase Signaling
- Monoclonal and Polyclonal Antibodies Research
- Zebrafish Biomedical Research Applications
- Fibroblast Growth Factor Research
Sichuan University
2024
West China Hospital of Sichuan University
2024
Sun Yat-sen University
2015-2023
The First Affiliated Hospital, Sun Yat-sen University
2019-2020
Union Hospital
2020
Jilin University
2020
Jilin Medical University
2020
Qingdao University
2019
Qingdao Municipal Hospital
2019
Hebei General Hospital
2013
Despite the well-established role of CMTM6 in stabilization cell surface PD-L1 cancer cells, mechanisms underlying expression and regulation are still largely unknown. Here we unexpectedly find a strikingly positive correlation between Hu-Antigen R (HuR) most types cancer. Mechanistically, elucidate HuR stabilizes mRNA via direct association with AU-rich elements (AREs) its 3'UTR predominantly up-regulates CMTM6, which is readily abolished by HuR-specific inhibitor, MS-444. Phenotypically,...
Abstract Background HER2-positive breast cancer is usually associated to the more aggressive progression and worse prognosis, but mechanism underlying innate resistance HER2-targeted therapy remains elusive. The scaffold protein SH3-domain-binding glutamic acid-rich protein-like (SH3BGRL) indicated as a tumor suppressor in some cancers, it highly expressed cancers. Here we characterized tumorigenic function of SH3BGRL HER2-expressing cells subsequent effect therapies. Methods interaction...
Non-alcoholic fatty liver disease caused by dietary factors such as a high fructose intake is growing global concern. The aim of this study was to investigate the intervention effects an endoplasmic reticulum stress (ERS) inhibitor 4-phenylbutyric acid (PBA) on steatosis induced high-fructose feeding in rats and possible underlying mechanisms. Wistar were divided into control, high‑fructose group (HFru) PBA (HFru-PBA) groups. initiated following 4 weeks feeding. After 8 feeding, ERS markers...
Phosphatase PRL-3 expression is positively associated to acute myeloid leukemia (AML) progression and drug resistance. SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL), a downstream effector of PRL-3, plays tumor suppressive role in solid tumors, but it remains elusive AML. Here, we followed up validated the relevance SH3BGRL AML 116 cases. Results showed that down-regulated 62.37% cases with poor prognosis. Cases positive response therapy accompanies SH3GRL restoration....
Cancer stem cells (CSCs) are responsible for tumor initiation, chemoresistance, metastasis, and relapse, but the underlying molecular origin of CSCs remains elusive. Here we identified that metastatic phosphatase regenerating liver 3 (PRL-3) transcriptionally upregulates SOX2 in expansion CSC sub-population from normal cancer cells. Mechanistically, upregulation is attributed to binding acetylated myocyte enhancer factor 2A (MEF2A) promoter In parallel, PRL-3 competitively binds Class IIa...
Abstract Vinculin is a highly conserved protein involved in cell proliferation, migration, and adhesion. However, the effects of vinculin on gastric cancer (GC) remain unclear. Therefore, we aimed to explore functional role GC, as well its underlying mechanism. Expression patients with GC was analyzed by real‐time polymerase chain reaction, Western blot analysis, immunohistochemistry. Overall survival evaluated Kaplan‐Meier method log‐rank test. The relationship between clinicopathological...
The metastasis-associated phosphatase of regenerating liver-3 (PRL-3) plays multiple roles in progression various human cancers; however, significance its role during development has not been addressed. Here we cloned and characterized the expression pattern zebrafish prl-3 transcript showed that it is ubiquitiously expressed first 24 h with both maternal zygotic expressions. transcripts become progressively restricted to notochord, vessels intestine by 96 post-fertilization. Notably,...
We found in previous study that metformin could treat sepsis myocarditis a mouse model. employed the zebrafish model organism to investigate effect of on myocarditis.Wild-type was used establish and combined with image software analysis cytokine detection, protective dose determined. The results showed immersion Escherichia coli cause 75% mortality make larvae appear as characteristics severe myocarditis. Pretreatment 10 mM for 3 hours effectively reduce heart congestion swelling increased...
Introduction Postoperative ileus (POI) is an inevitable complication after abdominal surgery, often hindering recovery and prolonging hospital stay. Despite the increasing use of electroacupuncture (EA) as alternative treatment for gastrointestinal dysfunction, its effectiveness POI still controversial. This study aims to verify efficacy safety EA in alleviating POI. Methods design The a multicentre, randomised, sham-controlled trial. A total 174 patients undergoing laparoscopic surgery...
SH3BGRL, an adaptor protein, is upregulated in breast cancers and indicates its tumorigenic role. But the function of SH3BGRL other types largely unknown. Here, we modulate expression level two liver cancer cells conduct both vitro vivo analyses cell proliferation tumorigenesis. Results demonstrate that notably inhibits arrests cycle LO2 HepG2 cells. Molecularly, upregulates ATG5 from proteasome degradation as well inhibitions Src activation downstream ERK AKT signaling pathways, which...