A5102825693- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cannabis and Cannabinoid Research
- Cancer-related Molecular Pathways
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Chromosomal and Genetic Variations
- Sepsis Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
First Affiliated Hospital of GuangXi Medical University
2018-2024
Guangxi Medical University
2018-2024
Sun Yat-sen University
2008-2016
South China University of Technology
2016
General Hospital of Guangzhou Military Command
2016
Chinese University of Hong Kong
2016
Ministry of Education of the People's Republic of China
2014
Zhongshan Hospital
2014
Third Affiliated Hospital of Sun Yat-sen University
2008
Abstract Long noncoding RNAs (lncRNAs) play multiple key regulatory roles in various cellular pathways. However, their functions HIV-1 latent infection remain largely unknown. Here we show that a lncRNA named NRON, which is highly expressed resting CD4 + T lymphocytes, could be involved latency by specifically inducing Tat protein degradation. Our results suggest NRON potently suppresses the viral transcription decreasing abundance of transactivator Tat. directly links to...
PIWI interacting RNAs (piRNAs) are highly expressed in germline cells and involved maintaining genome integrity by silencing transposons. These also DNA/histone methylation gene expression regulation somatic of invertebrates. The functions piRNAs vertebrates, however, remain elusive. We found that snoRNA-derived C (C′)/D′ (D)-box conserved abundant human CD4 primary T-lymphocytes. piRNA (piR30840) significantly downregulated interleukin-4 (IL-4) via sequence complementarity binding to...
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications invertebrates. However, its function mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, tumor-suppressive long non-coding RNA, potently upregulates transcription of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), proapoptotic protein, by inducing H3K4 methylation/H3K27 demethylation. Interestingly, PIWIL1/4...
Abstract Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining development of rational approach for therapeutic intervention complement system. C3 deficiency has been shown impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate protection effect wild-type mice by treatment with CR2-Crry, specific inhibitor activation. The expression glycine...
Abstract Polycomb group family is a class of proteins that have important roles in both physiological and pathological processes, its member Chromobox homolog 8 (CBX8) regulates cell differentiation, aging, cycle progression numerous carcinomas; however, the effects underlying mechanisms CBX8 hepatocellular carcinoma (HCC) are rarely reported. We found expression clinical HCC specimens correlates inversely with patient survival. In cells, we enforced overexpression induces...
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened commercial library identified hit compound bearing benzenesulfonamide quinoline scaffold that inhibited activity infectivity. Compounds were synthesized their SAR was studied. We 20 with low toxicity potent inhibit replication by affecting function.
Abstract Cholangiocarcinoma (CCA) is a severe malignancy usually producing poor prognosis and high mortality rate. MicroRNAs (miRNAs) have been reported in association with CCA; however, the role miR‐329 plays CCA condition still remains unclear. Therefore, this study was conducted to explore underlying mechanism of which influencing progression CCA. This work studied differential analysis expression chips obtained from Gene Expression Omnibus database. Next, determine both pituitary tumor...
Abstract Background Nonalcoholic steatohepatitis (NASH) is an advanced form of chronic fatty liver disease, which a driver hepatocellular carcinoma. However, the roles C5aR1 in NASH remain poorly understood. Here, we aimed to investigate functions and mechanisms on hepatic inflammation fibrosis murine model. Methods Mice were fed normal chow diet with corn oil (ND + Oil), Western (WD Oil) or carbon tetrachloride CCl 4 ) for 12 weeks. The effects C5a–C5aR1 axis progression analyzed underlying...
Alcohol-associated liver disease (ALD) is one of the most common chronic diseases worldwide. Fetuin-A (FetA) a plasma glycoprotein closely related to fat accumulation in liver. However, role FetA ALD remains unclear.
BACKGROUNDHepatocellular carcinoma (HCC) is a common malignant gastrointestinal tumor.There are currently few clinical diagnostic and prognostic markers for HCC.LncRNA cancer susceptibility candidate 9 (CASC9) long-chain non-coding RNA discovered in recent years, previous studies have found that lncRNA CASC9 participates the occurrence development of HCC, but its value remains unclear. AIMTo determine expression HCC value.
Pancreatic cancer is one of the deadliest cancers across world with an average 5-year survival rate less than <6%. In this study, gemcitabine (GEM) and HIF1α-siRNA loaded GE-11 peptide conjugated liposome was successfully prepared evaluated for its antitumor efficacy in pancreatic cells. The GE11 increased targeting specificity carrier intracellular concentrations Furthermore, synergistic combination GEM HIF1a-siRNA exhibited remarkable improvement declining cell proliferations. siRNA could...
TRAF-interacting protein (TRAIP) is a RING-type E3 ubiquitin ligase which has been implicated in various cellular processes, including NF-κB activation, DNA damage response, mitosis, and tumorigenesis. It considered as tumor suppressor basal cell carcinomas breast cancer previous studies. However, our current study, we found that TRAIP exhibited oncogenic properties liver cancer. In order to determine its effect on biology the potential mechanism, variety of advanced experimental technology...
Faciogenital Dysplasia 1 (FGD1) has been involved in a variety of biological processes, including cytoskeleton restructuring, cell morphology, cycle progression, and polarity. Abnormal expression FGD1 was also identified several types cancers, indicating its critical role the development cancers. However, little is known about hepatocellular carcinoma (HCC). In this study, HCC mined with RNA sequencing data from cancer genome atlas. By over-expressing or knocking down FGD1, effects on...
Imbalanced immune response and hepatic fibrosis are key factors related to the progression of chronic liver diseases. Tetramethylpyrazine (TMP), a natural alkaloid, has been widely used for treating injury. In this study, we explored effect TMP on mechanisms regulating autophagy.A rat model using an stellate cell line (HSC-T6) were created CCl4 platelet-derived growth factor (PDGF). Staining with haematoxylin eosin (HE), Masson's stain, TUNEL performed pathological diagnosis. ELISA, Western...
The interaction of CD40 with CD154 is a pivotal trigger immune cascade-inducing acute liver failure, however its clinical significance has not been well studied. present study aimed to investigate the implications serum-soluble (sCD154) levels and expression on monocytes in patients fulminant hepatic failure (FHF). results showed that serum sCD154 were significantly higher FHF than hepatitis (AH) healthy controls, also who died, compared those survived. We conclude high may be linked fatal...
The latency‐associated transcript (LAT) gene of herpes simplex virus (HSV)‐2 is the only detectable viral expressed during latent infection in neurons. LAT inhibits apoptosis and maintains latency by promoting survival infected However, whether functions HSV‐2 via its encoded RNAs or proteins remain unknown. Increasing evidence has indicated that likely to functionally promote establishment LAT‐encoded microRNAs (miRNAs). To explore RL1 fragment five adjacent miRNAs an effect on cell...
<h2>Abstract</h2> Brain death (BD) donors are the primary source of donor organs for liver transplantation. However, effects BD on livers and outcomes after transplantation remain unclear. Here, we explored role complement therapeutic effect inhibition in BD-induced injury posttransplantation a mouse model. For inhibition, used receptor 2 (CR2)-Crry, murine inhibitor C3 activation that specifically targets sites activation. In model, resulted cascade posttransplantation, mediated part...
<title>Abstract</title> Fatty acid-binding protein 4 (FABP4) plays an essential role in metabolism and inflammatory. However, the of FABP4 alcoholic steatohepatitis (ASH) remains unclear. This study aimed to investigate function underlying mechanisms progression ASH. Alcoholic hepatitis (AH) datasets were obtained from NCBI Gene Expression Omnibus (GEO). Bioinformatics analysis was performed screen key genes FABPs family. Wild-type (WT) FABP4-deficient (FABP4<sup>−/−</sup>) mice subjected...
Fatty acid-binding protein 4 (FABP4) plays an essential role in metabolism and inflammation. However, the of FABP4 alcoholic steatohepatitis (ASH) remains unclear. This study aimed to investigate function underlying mechanisms progression ASH. We first obtained hepatitis (AH) datasets from National Center for Biotechnology Information-Gene Expression Omnibus database conducted bioinformatics analysis identify critical genes FABP family. then established ASH models wild-type (WT)...
Background: Repeat laparoscopic liver resection has been used safely and effectively on hepatocellular carcinoma (HCC). However, few studies have performed repeat HCC surgery by a da Vinci robot. This study aims to evaluate the outcomes of patients with treated using robot or system at single centre. Methods: All robotic between April 2017 2020 were included in this retrospective study. Results: There 24 mean age 56 years who underwent for treatment The operations lasted 152 ± 25 min 142 34...