A5102855900- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Methemoglobinemia and Tumor Lysis Syndrome
- Ginseng Biological Effects and Applications
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- CRISPR and Genetic Engineering
- Neurological Complications and Syndromes
- Nanoparticle-Based Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
Guangxi Medical University
2018-2024
First Affiliated Hospital of GuangXi Medical University
2018-2024
Tumor Hospital of Guangxi Medical University
2022-2024
Guilin Medical University
2015-2019
Affiliated Hospital of Guilin Medical College
2017
Guangxi University
2014
Alfact Innovation (France)
2010
Abstract Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining development of rational approach for therapeutic intervention complement system. C3 deficiency has been shown impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate protection effect wild-type mice by treatment with CR2-Crry, specific inhibitor activation. The expression glycine...
Altered circulating hormones in ALS patients have been widely reported by previous observational studies, but whether these relationships are causal is unclear. Moreover, the potential therapeutic targets for and effects of plasma protein fluctuation on progression not fully understood. Therefore, we conducted a Mendelian randomization (MR) study to evaluate role 5 hormonal risk factors (insulin-like growth factor-1, IGF-1; sex hormone-binding globulin, SHBG; free testosterone, FT; total TT;...
The aim of the present study was to investigate prognostic value B-cell associated protein 31 (BAP31) in human primary hepatocellular carcinoma (HCC).BAP31 levels were evaluated by immunohistochemistry on tissue microarrays. integral optical density, representing expression level BAP31 each sample, calculated with image-pro plus. Immunohistochemical analysis 74 paired HCC tissues and peritumoral non-cancerous showed that significantly higher tumour (P = 0.025). 234 cases a training cohort 63...
Abstract Cholangiocarcinoma (CCA) is a severe malignancy usually producing poor prognosis and high mortality rate. MicroRNAs (miRNAs) have been reported in association with CCA; however, the role miR‐329 plays CCA condition still remains unclear. Therefore, this study was conducted to explore underlying mechanism of which influencing progression CCA. This work studied differential analysis expression chips obtained from Gene Expression Omnibus database. Next, determine both pituitary tumor...
Cuproptosis has been identified as a key player in the development of several diseases. In this study, we investigate potential role cuproptosis-related genes pathogenesis nonalcoholic fatty liver disease (NAFLD).The gene expression profiles NAFLD were obtained from Gene Expression Omnibus database. Differential (CRGs) determined between and normal tissues. Protein-protein interaction, correlation, function enrichment analyses performed. Machine learning was used to identify hub genes....
BACKGROUNDHepatocellular carcinoma (HCC) is a common malignant gastrointestinal tumor.There are currently few clinical diagnostic and prognostic markers for HCC.LncRNA cancer susceptibility candidate 9 (CASC9) long-chain non-coding RNA discovered in recent years, previous studies have found that lncRNA CASC9 participates the occurrence development of HCC, but its value remains unclear. AIMTo determine expression HCC value.
Background and Aims Cholestatic liver injury (CLI), which is associated with inflammatory reactions oxidative stress, a serious risk factor for postoperative complications. Complement system involved in wide range of disorders, including cholestasis. The present study assessed the role complement CLI therapeutic effect site-targeted inhibitor CR2-Crry CLI. Methods Wild-type gene deficient mice underwent common bile duct ligation (BDL) to induce or sham operation, followed by treatment GdCl3....
Pancreatic cancer is one of the deadliest cancers across world with an average 5-year survival rate less than <6%. In this study, gemcitabine (GEM) and HIF1α-siRNA loaded GE-11 peptide conjugated liposome was successfully prepared evaluated for its antitumor efficacy in pancreatic cells. The GE11 increased targeting specificity carrier intracellular concentrations Furthermore, synergistic combination GEM HIF1a-siRNA exhibited remarkable improvement declining cell proliferations. siRNA could...
The present study aimed to investigate the regulatory networks involving long noncoding RNA (lncRNA), microRNA (miRNA), mRNA, genetic mutations and epigenetic modifications in hepatocellular carcinoma (HCC) by analyzing datasets from Cancer Genome Atlas (TCGA) database. TCGA was mined, miRNAs, lncRNAs mRNAs that were differentially expressed HCC identified using R software. A gene network constructed Cytoscape Representative genes selected for functional enrichment analysis Gene Ontology...
TRAF-interacting protein (TRAIP) is a RING-type E3 ubiquitin ligase which has been implicated in various cellular processes, including NF-κB activation, DNA damage response, mitosis, and tumorigenesis. It considered as tumor suppressor basal cell carcinomas breast cancer previous studies. However, our current study, we found that TRAIP exhibited oncogenic properties liver cancer. In order to determine its effect on biology the potential mechanism, variety of advanced experimental technology...
Faciogenital Dysplasia 1 (FGD1) has been involved in a variety of biological processes, including cytoskeleton restructuring, cell morphology, cycle progression, and polarity. Abnormal expression FGD1 was also identified several types cancers, indicating its critical role the development cancers. However, little is known about hepatocellular carcinoma (HCC). In this study, HCC mined with RNA sequencing data from cancer genome atlas. By over-expressing or knocking down FGD1, effects on...
Imbalanced immune response and hepatic fibrosis are key factors related to the progression of chronic liver diseases. Tetramethylpyrazine (TMP), a natural alkaloid, has been widely used for treating injury. In this study, we explored effect TMP on mechanisms regulating autophagy.A rat model using an stellate cell line (HSC-T6) were created CCl4 platelet-derived growth factor (PDGF). Staining with haematoxylin eosin (HE), Masson's stain, TUNEL performed pathological diagnosis. ELISA, Western...
Hepatic ischemia-reperfusion injury (HIRI) is caused by blood flow recovery following ischemia. Baicalein (BAI), a natural antioxidant used in traditional Chinese medicine, eliminates excessive free radicals and protects the structure of cell membrane. However, its protective mechanism against HIRI still unclear. The present study investigated underlying using mouse model. Liver was evaluated serum levels alanine aminotransferase aspartate aminotransferase, hematoxylin-eosin staining...
Background and aims Cuproptosis has emerged as a significant contributor in the progression of various diseases. This study aimed to assess potential impact cuproptosis-related genes (CRGs) on development hepatic ischemia reperfusion injury (HIRI). Methods The datasets related HIRI were sourced from Gene Expression Omnibus database. comparative analysis differential gene expression involving CRGs was performed between normal liver samples. Correlation analysis, function enrichment analyses,...
To exploit a cross passive immunotherapy for enterovirus-induced hand-foot-and-mouth disease (HFMD), the antiviral activity of neutralizing antibody against enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) was investigated in vitro. White Leghorn specific-pathogen-free chickens were immunized with EV71 antigens specific isolated immunoglobulin (IgY) prepared from chicken egg yolk. IgY further purified characterized by SDS-PAGE, ELISA, western blotting bidirectional immune agar diffusion...
Hepatocellular carcinoma (HCC) is a highly malignant and common tumor. Many biomarkers have been identified for HCC. However, the available ones are not accurate enough in term of prognostic value new markers needed prognosis this disease. Sirtuins NAD(+)-dependent histone deacetylases involved many biological processes cancers, consisting family members SIRT1-SIRT7. SIRTs HCC remains largely unknown.Differential expression survival analysis were assessed patients with using Oncomine UALCAN...
<h2>Abstract</h2> Brain death (BD) donors are the primary source of donor organs for liver transplantation. However, effects BD on livers and outcomes after transplantation remain unclear. Here, we explored role complement therapeutic effect inhibition in BD-induced injury posttransplantation a mouse model. For inhibition, used receptor 2 (CR2)-Crry, murine inhibitor C3 activation that specifically targets sites activation. In model, resulted cascade posttransplantation, mediated part...
FBXL19 is a member of the Skp1-Cullin-F-box family E3 ubiquitin ligases and linked to variety vital biological processes, such as cell proliferation, migration, differentiation. Previous studies have identified it an oncogene in breast cancer glioma. However, its role hepatocellular carcinoma (HCC) remains unclear. To comprehensively elucidate tumour biology underlying mechanisms, sophisticated methods, including bioinformatics analysis, RNA-sequencing technique, vitro experiments, were...
During reprogramming, there is exchange of histone H1c and the oocyte-specific linker histone, may play a critically important role in reprogramming process somatic cell nuclear transfer (SCNT). The aim present study was to investigate gene SCNT Chinese swamp buffalo (Bubalus bubalis) using RNA interference (RNAi). sequences were obtained H1c-RNAi vectors designed, synthesised then transfected into fetal skin fibroblast line. Expression determined by real-time polymerase chain reaction...
To investigate the dynamic expression of cluster differentiation 47 (CD47) and its ligands signaling regulatory protein α (SIRPα) thrombospondin-1 (TSP-1) in mice infected with Toxoplasma gondii second third trimesters.C57BL/6J (6 to 8 weeks old) were used for modeling T. infection first trimester, pregnant randomly divided into normal control groups, 10 each group. Pregnant group intraperitoneally injected 150 tachyzoites on gestational day (Gd) 6.5, while same volume physiological saline...
Abstract A comprehensive report on the global burden of glucose 6-phosphate dehydrogenase (G6PD) deficiency is currently unavailable. Here we assess G6PD and trends by analyzing data from Global Burden Disease, Injuries, Risk Factors Study (GBD) 2019, including number age-standardized rate incidence (ASIR), prevalence (ASPR), Years Lived with Disability (YLDs) 1990 to 2019. Globally, there were increased in incident, prevalent YLDs cases, ASIR ASPR also during this period. Females had a...