A5101808715- Nonlinear Dynamics and Pattern Formation
- Acute Kidney Injury Research
- Neural dynamics and brain function
- Chaos control and synchronization
- RNA modifications and cancer
- stochastic dynamics and bifurcation
- Chronic Kidney Disease and Diabetes
- Quantum chaos and dynamical systems
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- GaN-based semiconductor devices and materials
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Mosquito-borne diseases and control
- Cancer, Lipids, and Metabolism
- Hydrogen's biological and therapeutic effects
- Ion channel regulation and function
- Photonic Crystals and Applications
- RNA Interference and Gene Delivery
Guangdong Academy of Medical Sciences
2020-2025
Guangdong Provincial People's Hospital
2021-2025
Southern Medical University
2023-2025
Guilin Medical University
2015-2024
North Sichuan Medical University
2023-2024
Jinan University
2024
Zhengzhou University
2023-2024
Northwest A&F University
2021-2023
Sun Yat-sen University
2021-2023
Sun Yat-sen Memorial Hospital
2023
Abstract Background Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting failure MSC therapy. This study investigated whether the combination melatonin human umbilical cord mesenchymal (hUC-MSCs) was superior hUC-MSCs alone ameliorating high-fat diet streptozocin (STZ)-induced type II diabetes mellitus (T2DM) a mouse model. Methods Mice were divided into four...
Abstract Extracellular pH is usually low in solid tumors, contrast to the approximately neutral intracellular pH. V-ATPase, which overly functions some cancers with metastatic potential, plays an important role maintaining cytosolic pH, very acidic luminal and extracellular ATP6L, 16 kDa subunit of proton pump can provide hydrophilic transmembrane path. In this study, ATP6L a human hepatocellular carcinoma cell line highly potential (HCCLM3) was knocked down using DNA vector–based small...
The existing treatment modalities for skin injuries mainly include dressings, negative-pressure wound treatment, autologous grafting, and high-pressure treatment. All of these therapies have limitations such as high time cost, the inability to remove inactivated tissue in a timely manner, surgical debridement, oxygen toxicity. Mesenchymal stem cells unique self-renewal ability wide differentiation potential, they are one most promising cell types therapy great application prospects field...
Malnutrition is prevalent in hepatocellular carcinoma (HCC) patients, linked to poor outcomes, necessitating early intervention. This study aimed investigate malnutrition HCC assess Nutrition Risk Screening 2002 (NRS-2002) and Patient-Generated Subjective Global Assessment (PG-SGA)
Narrowband photodetection is an important measurement technique for material analysis and sensing, example, nondispersive infrared sensing technique. Both photoactive engineering nanophotonic filtering schemes have been explored to realize wavelength-selective photodetection, while most devices a responsive bandwidth larger than 2% of the operating wavelength, limiting performance. Near-infrared with less 0.2% wavelength was demonstrated experimentally in Au/Si Schottky nanojunctions. A...
Chronic kidney disease (CKD) is prevalent among patients with coronary artery (CAD) and exacerbates myocardial ischemia. However, the survival benefit of percutaneous intervention (PCI) across different stages CKD remains controversial. CAD (n = 17,418) (mean age, 69.5 ± 9.9 years; 70.9% male) were included in Cardiorenal Improvement II cohort from 2007 to 2020. Patients grouped by PCI or medical treatment further categorized 3a-5 CKD. Multivariable Cox regression was performed investigate...
Purpose: The identification of prognostic markers for colorectal cancer (CRC) is needed clinical practice. Fructose-bisphosphate aldolase A (ALDOA) and DEAD box p68 RNA helicase (DDX5) are commonly overexpressed in correlate with tumorigenesis. However, association between expression ALDOA DDX5, CRC outcome has not been reported. Patients methods: We used 141 formalin-fixed paraffin-embedded (FFPE) specimens collected from 105 patients treated at the Affiliated Hospital Guilin Medical...
The aim of the present study was to investigate prognostic value B-cell associated protein 31 (BAP31) in human primary hepatocellular carcinoma (HCC).BAP31 levels were evaluated by immunohistochemistry on tissue microarrays. integral optical density, representing expression level BAP31 each sample, calculated with image-pro plus. Immunohistochemical analysis 74 paired HCC tissues and peritumoral non-cancerous showed that significantly higher tumour (P = 0.025). 234 cases a training cohort 63...
The mean first passage time (MFPT) in a phenomenological gene transcriptional regulatory model with non-Gaussian noise is analytically investigated based on the singular perturbation technique. effect of phenomenon stochastic resonance (SR) then disclosed new combination adiabatic elimination and linear response approximation. Compared results Gaussian case, it found that bounded inhibits transition between different concentrations protein, while heavy-tailed accelerates transition. It also...
Abstract The envelope (E) protein of the Japanese encephalitis virus (JEV) is a key for infection and adsorption host cells, which determines virulence regulates intensity inflammatory response. mutation multiple aa residues in E plays critical role attenuated strain JEV. This study demonstrated that Asp to Gly, Ser, His E389 site, respectively, replication ability viruses cells was significantly reduced, viral neuroinvasiveness different degrees. Among them, at site enhanced flexibility...
Caprin-1 has been found to promotes osteosarcoma tumor growth, lung metastasis in mice, regulating the proliferation and invasion of human breast cancer cells up-regulated proton beam irradiated melanoma cells. However, its clinical role, biological function hepatocellular carcinoma (HCC) remains unknown. In present study, we investigated significance Caprin1 HCC. expression was detected by immunohistochemistry, level analyzed 65 HCC tissues paired peritumoral tissue. Prognostic value...
// Xiaojia Liu 1, 4 * , Ning Tan 2, Hongtao Liao 2 Guangdong Pan 3 Qing Xu Rong Zhu 1 Liping Zou Songqing He 5 and Hongguang Department of Pathology, Basic Medical School, Shanghai College, Fudan University, 200032, China Laboratory Liver Injury Repair Molecular Medicine, Guilin 541001, Hepatobiliary Surgery, The People's Hospital Liuzhou, Liuzhou 545001, Division Surgical Huashan Hospital, Affiliated Guangxi Nanning 530021, These authors have contributed equally to this work Correspondence...
Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor that frequently mutated in human cancers. Our previous findings have indicated SPOP and functions as a novel tumor suppressor hepatoblastoma (HB). However, the biological roles clinical significance of this hepatocellular carcinoma (HCC) remain unknown. In study, we found expression level was downregulated HCC primary tumors by quantitative real-time PCR also reduced 72 pairs tissue microarrays immunohistochemical analyses....
Extracellular matrix metalloproteinase inducer (EMMPRIN), a plasma membrane protein of the immunoglobulin (Ig) superfamily, has been reported to promote cancer cell invasion and metastasis in several human malignancies. However, roles different EMMPRIN isoforms their associated mechanisms head neck progression remain unknown. Using quantitative real-time PCR, we found that isoform 2 (EMMPRIN-2) was only overexpressed both tissues lines it with metastasis. To determine effects EMMPRIN-2 on...
The renal renin-angiotensin system (RAS) and the ultrasensitive energy sensor AMP-activated protein kinase (AMPK) have been implicated in normal aberrant states of kidney, but interaction between RAS AMPK remains unknown.Ninety-six rats were stratified into four groups: sham, uninephrectomised, uninephrectomised treated with angiotensin-converting enzyme inhibitor lisinopril or angiotensin receptor blocker losartan. Histopathological examination at 9 months post-operation biochemical...
Overexpression of pyrroline-5-carboxylate reductase 1 (PYCR1) has been associated with the development certain cancers; however, no studies have specifically examined role PYCR1 in hepatocellular carcinoma (HCC). Based on The Cancer Genome Atlas expression array and meta-analysis conducted using Gene Expression Omnibus database, we determined that was upregulated HCC compared to adjacent nontumor tissues (P < 0.05). These data were verified quantitative real-time polymerase chain reaction,...
Surgical ventricular reconstruction (SVR) is an alternative therapeutic approach in patients with refractory heart failure (HF), but residual remodeling after SVR limits the improvement of HF. Recently, we reported that may act as environmental cue to reactivate endogenous proliferation cardiomyocytes; however, it unclear whether enhancing cardiomyocyte regeneration further improves HF SVR. We aimed explore circular RNAs (circRNAs) would involved and their mechanisms. Male C57BL/6 mice were...
Neutrophil polarization contributes to inflammation and its resolution, but the role of neutrophil in myocardial ischemia/reperfusion (I/R) injury remains unknown. Cardiomyocytes (CMs) participate cardiac by secreting extracellular vesicles (EVs). Therefore, we investigated I/R mechanism which CM-derived EVs regulated polarization. In present study, our data showed that N1 enlarged infarct size exacerbated dysfunction at early stage I/R. Further, CM-EV-derived miR-9-5p was identified as a...
Abundant evidence proves the therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) in treatment diabetes mellitus. However, problems have not been solved that viability ADMSCs were inconsistent and quickly undergo senescence after vitro cell culture. In addition, is still satisfactory. this study, melatonin (MLT) was added to canine ADMSC culture medium, treated used treat type 2 mellitus (T2DM). Our research reveals adding MLT medium can promote ADMSCs. This depends on...