A5046535862- Reproductive System and Pregnancy
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Pregnancy and preeclampsia studies
- Cancer survivorship and care
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Dermatology and Skin Diseases
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Nanoplatforms for cancer theranostics
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Kruppel-like factors research
- Breast Implant and Reconstruction
- Cancer, Lipids, and Metabolism
- Pregnancy-related medical research
Zhejiang Chinese Medical University
2017-2025
Hangzhou Cancer Hospital
2024
Zhejiang Provincial Hospital of TCM
2017
Abstract Background Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m 5 C) on tumor microenvironment (TME) acute myeloid leukemia (AML) is still unknown present. Methods We assessed patterns m C among 417 AML cases by using nine regulators. Thereafter, we associated those identified with TME cell infiltration features. Additionally, stepwise regression and LASSO Cox analyses were for...
Primary liver cancer is associated with high morbidity and mortality rate. In about 50% of cases, primary related to the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway. Wogonoside an active component extracted from Scutellaria baicalensis. Its antitumor effects in are scarcely known. This study explores correlation between wogonoside PI3K/Akt pathway vitro. THLE-2 cells HepG2 were treated different concentrations establish low-, medium- high- dose groups, concentration each group was...
Visceral hypersensitivity induced by stress is quite common in irritable bowel syndrome (IBS) patients. Probiotics play an important role reducing visceral IBS However, the mechanism has not been clearly elucidated. In this study, we investigated of nod-like receptor pyrin domain-containing protein 6 (NLRP6) Clostridium butyricum-regulated stress. Our results showed that NLRP6 was down-regulated group colon tissues. addition, IL-18, IL-1β, myeloperoxidase (MPO), d-lactic acid (D-LA), and...
The mortality rate of ovarian cancer (OC) is the highest among all gynecologic cancers. To predict prognosis and efficacy immunotherapy, we identified new biomarkers.The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression Project (GTEx) databases were used to extract transcriptomes. By performing co-expression analysis, necroptosis-associated long noncoding RNAs (lncRNAs). We least absolute shrinkage selection operator (LASSO) build risk model. qRT-PCR assay was conducted confirm...
Abstract To determine the impact of breast conservation on quality life and identify treatment-related other demographic factors associated with post-breast cancer treatment life. A prospective study was conducted 392 women who underwent surgery at Hangzhou Cancer Hospital from January 1, 2013, to December 31, 2022. Operable patients had completed all treatments except endocrine therapy were included. Patients tumor recurrence/metastasis, bilateral or male cancer, primary malignancies...
Cancer-associated fibroblasts (CAFs) significantly contribute to tumor progression and the development of resistance therapies across a range malignancies, notably breast cancer. This study aims elucidate specific role prognostic relevance CALU multiple cancer types.
Ginsenoside Rb1 (GRb1) is the main active ingredient of traditional Chinese medicine ginseng and exhibits broad pharmaceutical activities.GRb1 can significantly stimulate haematopoietic function enhance T lymphocyte proliferation differentiation [1,2].Shengxueling capsules, in which GRb1, have positive effects on treatment severe aplastic anemia (AA) [3,4], but mechanism remains unknown.Tu et al. [5] demonstrated that expression co-stimulatory molecules CD80 CD86 surface dendritic cells...
Apolipoprotein A-I (APOA1) performs different roles in subtypes of breast cancer. It is hypothesized to function as a tumor suppressor basal-like cancer (BLBC). However, the specific role APOA1 BLBC and its underlying mechanisms remain unknown. The findings present study demonstrated positive correlation between expression level overall survival patients with BLBC. Ectopic effectively inhibits proliferation metastasis cells <em>in vitro</em>, these effects are closely related DNA...
Women with an elevated basal FSH indicate diminished ovarian reserve and reduced oocyte embryo numbers. DMSCs are likely to be involved in immune tolerance of pregnancy maintenance. We investigate the effect follicle-stimulating hormones on immunomodulatory functions DMSCs.DMSCs were primary cultured from decidual tissue. Pretreated mitomycin C, combined CD4+ T lymphocytes, + CD4+T co-culture system was established. Different physiological dose (3 ng/ml,10 ng/ml,30 ng/ml,100 ng/ml) used...