A5039894762- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Heat shock proteins research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Hepatitis B Virus Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Chromatin Remodeling and Cancer
- Cytokine Signaling Pathways and Interactions
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- interferon and immune responses
Shandong Institute for Product Quality Inspection
2025
Wuhan University
2025
Fudan University Shanghai Cancer Center
2014-2024
Southwest Medical University
2024
Union Hospital
2024
Fujian Medical University
2024
Jiangsu Academy of Agricultural Sciences
2023
Shanghai Medical College of Fudan University
2008-2023
The University of Texas Health Science Center at Houston
1997-2020
Shanghai Jiao Tong University
2011-2015
Cancer cells possess a unique metabolic phenotype that allows them to preferentially utilize glucose through aerobic glycolysis. This phenomenon is referred as the “Warburg effect.” Accumulating evidence suggests microRNAs (miRNAs), class of small noncoding regulatory RNAs, interact with oncogenes/tumor suppressors and induce such reprograming in cancer cells. To systematically study roles miRNAs cells, we developed gain‐of‐function miRNA screen HeLa Subsequent investigation characterized...
Human cancer cell lines are fundamental models for research and therapeutic strategy development. However, there is no characterization of circular RNAs (circRNAs) in a large number lines.Here, we apply four circRNA identification algorithms to heuristically characterize the expression landscape circRNAs across ~ 1000 human from CCLE polyA-enriched RNA-seq data. By using integrative analysis experimental approaches, explore landscape, biogenesis, functional consequences, drug response...
Abstract It is widely accepted that chronic hepatitis B virus (HBV) infection the result of an ineffective antiviral immune response against HBV infection. Our previous study found surface Ag (HBsAg) was related to decreased cytokine production induced by TLR2 ligand (Pam3csk4) in PBMCs from patients. In this study, we further explored mechanism involved inhibitory effect HBsAg on signaling pathway. The results showed both Pam3csk4-triggered IL-12p40 mRNA expression and IL-12...
A powerful way to identify driver genes with causal roles in carcinogenesis is detect genomic regions that undergo frequent alterations cancers. Here we identified 1,241 of somatic copy number 58 paired hepatocellular carcinoma (HCC) tumors and adjacent nontumor tissues using genome-wide single nucleotide polymorphism (SNP) 6.0 arrays. Subsequently, by integrating profiles gene expression signatures derived from the same HCC patients, 362 differentially expressed within aberrant regions....
Abstract Circular RNAs (circRNAs) are an intriguing class of widely prevalent endogenous RNAs, the vast majority which have not been characterized functionally. Here, we identified a novel oncogenic circRNA originating from back‐splicing Exon2 and Exon3 tumor suppressor gene, ARHGAP35 (also known as P190‐A), termed circARHGAP35. observe that circARHGAP35 linear antithetical expression functions. Interestingly, contains 3867 nt long ORF with m 6 A‐modified start codon encodes truncated...
Metabolic reprogramming is often observed in carcinogenesis, but little known about the aberrant metabolic genes involved tumorigenicity and maintenance of stemness cancer cells. Sixty-seven oncogenic metabolism-related liver by vivo CRISPR/Cas9 screening are identified. Among them, acetyl-CoA carboxylase 1 (ACC1), aldolase fructose-bisphosphate A (ALDOA), fatty acid binding protein 5 (FABP5), hexokinase 2 (HK2) strongly associated with stem cell properties. HK2 further facilitates...
Abstract Background/Aims Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine‐1‐phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene tumorigenesis. However, little known about the precise role SphK1/S1P pathway human liver cancer, especially regarding metastasis hepatocellular carcinoma ( HCC ). Materials methods The expression SphK1 was detected by quantitative reverse‐transcription PCR . In addition, transwell cell migration...
The identification of prognostic markers for hepatocellular carcinoma (HCC) is needed clinical practice. Tripartite motif-containing 35 (TRIM35) a tumor suppressor HCC. TRIM35 inhibits phosphorylation pyruvate kinase isoform M2 (PKM2), which involved in aerobic glycolysis cancer cells. We found that expression PKM2 was significantly increased HCC tissues. This overexpression correlated with high TNM stage and level vascular invasion. Patients who were positive negative had shorter overall...
Background and Aims The nuclear factor kappa B (NF‐κB) signaling pathway is important for linking inflammation tumorigenesis. Here, we characterized an NF‐κB activation–induced long intergenic noncoding (LINC) RNA in hepatocellular carcinoma (HCC), LINC00665, that contributes to the enhanced cell proliferation of HCC cells both vitro vivo . Approach Results LINC00665 physically interacts with double‐stranded (dsRNA)‐activated protein kinase (PKR), enhances its activation, maintains stability...
Heat shock proteins (HSPs), a representative family of chaperone genes, play crucial roles in malignant progression and are pursued as attractive anti-cancer therapeutic targets. Despite tremendous efforts to develop drugs based on HSPs, no HSP inhibitors have thus far reached the milestone FDA approval. There remains an unmet need further understand functional HSPs cancer.We constructed network for across ~ 10,000 tumor samples from The Cancer Genome Atlas (TCGA) normal Genotype-Tissue...
Background and Aims Alternative splicing (AS) is a key step that increases the diversity complexity of cancer transcriptome. Recent evidence has highlighted AS an increasingly crucial role in cancer. Nonetheless, mechanisms underlying its dysregulation hepatocellular carcinoma (HCC) remain elusive. Here, we report expression RNA‐binding protein p54 nrb /non‐POU domain‐containing octamer‐binding (NONO) frequently increased patients with HCC associated poor outcomes. Approach Results Knockdown...
Long terminal repeat (LTR) retrotransposons are a major class of transposable elements, accounting for 8.67% the human genome. LTRs can serve as regulatory sequences and drive transcription tissue or cancer-specific transcripts. However, role these LTR-activated transcripts, especially long non-coding RNAs (lncRNA), in cancer development remains largely unexplored. Here, we identified novel lncRNA derived from MER52A (lncMER52A) that was exclusively expressed hepatocellular carcinoma (HCC)....
Abstract RNA helicases are dysregulated in tumors. Here, we identified DHX37 as one of the top helicase genes with upregulated expression hepatocellular carcinoma (HCC). promoted proliferation liver cancer cells vitro and vivo. Epigenomic profiling DHX37-knockdown control HCC revealed that is associated superenhancer activity. Mechanistically, interacted pleiotropic regulator 1 (PLRG1) to transcriptionally activate cyclin D1 (CCND1) via co-occupation its promoter elements. PLRG1 cell...
Abstract Aldolase A (ALDOA), a crucial glycolytic enzyme, is often aberrantly expressed in various types of cancer. Although ALDOA has been reported to play additional roles beyond its conventional enzymatic role, nonmetabolic function and underlying mechanism cancer progression remain elusive. Here, it shown that promotes liver growth metastasis by accelerating mRNA translation independent catalytic activity. Mechanistically, interacted with insulin‐ like factor 2 mRNA‐binding protein 1...
Under the influence of complex theory, fractal, as a nonlinear geometry, reveals appearance and operation law real world, has ability to accurately quantify complexity system, been widely used in many disciplines recent years. Especially field architecture, which is closely related fractal guiding form rule can greatly expand scope architectural design theoretical research. Starting with self-similarity, most essential morphological feature through deconstruction analysis classical geometric...
Minimal residual disease (MRD) is of the most important factor for predicting prognosis and guiding treatment acute lymphoblastic leukemia (ALL). In this study, we investigated prognostic significance leukemia-associated immunophenotypes (LAIPs) as assessment index MRD in 125 adult B-lineage ALL (B-ALL) patients by eight-color flow cytometry. The LAIPs could be identified 96% 81.6% with sensitivity 10(-4) 10(-5), respectively. MRD-negative status clearly predict a favorable 2-year...