A5100752804- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Botulinum Toxin and Related Neurological Disorders
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Synthetic Organic Chemistry Methods
- Ion Channels and Receptors
- Circular RNAs in diseases
- Neurotransmitter Receptor Influence on Behavior
- Heat shock proteins research
- Estrogen and related hormone effects
- Hippo pathway signaling and YAP/TAZ
- Musculoskeletal pain and rehabilitation
- Lipid metabolism and biosynthesis
- Biochemical effects in animals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Anesthesia and Pain Management
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
Lanzhou University
2023-2024
Fujian Medical University
2023-2024
Fujian Provincial Hospital
2023-2024
National Cheng Kung University
2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2020-2024
People’s Hospital of Linqing
2024
Xian Yang Central Hospital
2024
Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD–HCC through modulating gut microbiota and its metabolites. Design High-fat/high-cholesterol (HFHC), high-fat/low-cholesterol or normal chow diet was fed to C57BL/6 male littermates for 14 months. Cholesterol-lowering drug atorvastatin administered HFHC-fed mice. Germ-free mice were transplanted...
Abstract Long noncoding RNAs (lncRNAs) play important roles in various biological processes such as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA, named liver fibrosis-associated lncRNA1 (lnc-LFAR1), promotes fibrosis. We demonstrate lnc-LFAR1 silencing impairs hepatic stellate cells (HSCs) activation, reduces TGFβ-induced hepatocytes apoptosis vitro attenuates both CCl 4 - bile duct ligation-induced fibrosis mice. Lnc-LFAR1 the binding of Smad2/3...
Recent studies have highlighted the role of gut microbiota and their metabolites in non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). We aimed to identify specific beneficial bacterial species that could be used prophylactically prevent NAFLD-HCC.
The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature Alzheimer's disease (AD), and enhanced cleavage precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) has major causative role AD. Despite their prominence AD pathogenesis, regulation BACE1 APP incompletely understood. In this study, we report that circular RNA sponge for miR-7 (ciRS-7) an important regulating levels. Previous studies have shown ciRS-7, which highly expressed human brain,...
Abstract Hepatic fibrosis is a common pathological consequence of sustained wound healing response to continuous liver injury, characterized by increased production and accumulation extracellular matrix. If unresolved, the fibrotic process results in organ failure, eventually death after development cirrhosis. It has been suggested that macrophages play central role progression hepatic fibrosis, which related inflammation pyroptosis, novel programmed proinflammatory cell death. However, it...
Abstract There is strong comorbidity between chronic pain and depression, although the neural circuits mechanisms underlying this association remain unclear. By combining immunohistochemistry, tracing studies western blotting, with use of different DREADDS (designer receptor exclusively activated by designer drugs) behavioural approaches in a rat model neuropathic (chronic constriction injury), we explore how arises. To end, evaluated time-dependent plasticity noradrenergic locus coeruleus...
Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number studies in humans concluded that pain-associated negative affect more pronounced when localized the left side body. It has been suggested such bias results from cortical function lateralization. not known, however, if other behavioral changes are differentially affected left- right-sided pain. To test this hypothesis, performance rats with unilateral spared nerve injury...
Background/Aims: Osteosarcoma is a malignant tumor associated with high mortality; however, no effective therapies for the disease have been developed. Several studies focused on elucidating pathogenesis of osteosarcoma and aimed to develop novel disease. Quercetin vital dietary flavonoid that has shown variety anticancer effects, as it induces cell cycle arrest, apoptosis, differentiation involved in adhesion, metastasis angiogenesis. Herein, we investigate effects quercetin migration...
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which results hypertrophy and subsequent heart failure. Chronic inflammation the diabetic loss of cardiomyocytes subsequentially dysfunction. Accumulated evidence implicated pyroptosis as vital contributor to hyperglycemia-induced inflammatory response. Exendin-4, GLP analog, promotes survival cardiovascular diseases, including cardiomyopathy. However, role Exendin-4 remains be elucidated. Our study...
Heat shock proteins (HSPs), a representative family of chaperone genes, play crucial roles in malignant progression and are pursued as attractive anti-cancer therapeutic targets. Despite tremendous efforts to develop drugs based on HSPs, no HSP inhibitors have thus far reached the milestone FDA approval. There remains an unmet need further understand functional HSPs cancer.We constructed network for across ~ 10,000 tumor samples from The Cancer Genome Atlas (TCGA) normal Genotype-Tissue...
Long non-coding RNAs (lncRNAs) are involved in numerous biological functions and pathological processes.However, the clinical significance of lncRNAs their liver fibrosis remain largely unclear.Methods: The transcript lncRNA SCARNA10 serum samples from patients with advanced hepatic fibrosis, tissues two mouse models, cultured stellate cells (HSCs) was determined by real-time RT-PCR.The effects lentivirus-mediated knockdown or over-expression were examined vitro vivo.Moreover, mechanisms...
Nonalcoholic fatty liver disease (NAFLD), the most common chronic disease, can progress into nonalcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. Bile acids such as ursodeoxycholic acid (UDCA) play an essential role in pathogenesis of NAFLD by regulating level sterol regulatory element-binding protein (SREBP) 1c, but underlying mechanism remains elusive. Increased evidence indicates that AKT/mTOR/SREBP-1 signaling pathway is a key to regulate hepatic cellular...
Backgrounds & AimsSqualene epoxidase (SQLE) is the rate-limiting enzyme for cholesterol biosynthesis. We elucidated functional significance, molecular mechanisms, and clinical impact of SQLE in nonalcoholic steatohepatitis (NASH).MethodsWe performed studies with hepatocyte-specific Sqle overexpression transgenic (Sqle tg) mice given high-fat high-cholesterol (HFHC) or methionine- choline-deficient (MCD) diet to induce NASH. downstream target carbonic anhydrase III (CA3) was identified using...
Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation liver sinusoidal endothelial cell (LSEC) phenotype is critical early event the fibrotic process. However, biological function lncRNAs LSEC still remains unclear.The expression level lncRNA Airn was evaluated both livers and serums, well mouse livers. Gain- loss-of-function experiments were performed to detect effect on differentiation hepatic stellate (HSC) activation...