A5069468683- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Hemispheric Asymmetry in Neuroscience
- Neuroendocrine regulation and behavior
- Musculoskeletal pain and rehabilitation
- Anesthesia and Neurotoxicity Research
- Neural and Behavioral Psychology Studies
- Spinal Cord Injury Research
- Pain Management and Placebo Effect
- Spatial Neglect and Hemispheric Dysfunction
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Botulinum Toxin and Related Neurological Disorders
- Morphological variations and asymmetry
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Electrospun Nanofibers in Biomedical Applications
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Erythrocyte Function and Pathophysiology
- Computational Drug Discovery Methods
University of Minho
2016-2025
Clinical Academic Center of Braga
2017-2024
University of Helsinki
2007
Chronic pain syndromes encompass several clinical entities that frequently affect the individuals’ emotional and cognitive behaviours which, in turn, can also alter perception. Additionally, both perception motivational-affective change with increasing age. In order to evaluate influence of age upon interaction between chronic affective/cognitive behaviours, 3-, 10- 22-month-old rats 1 month neuropathy (spared nerve injury, SNI model) were compared age-matched sham-operated controls open...
Spinal cord injury (SCI) represents a significant health and social problem, therefore it is vital to develop novel strategies that can specifically target it. In this context, the objective of present work was new range three-dimensional (3D) tubular structures aimed at inducing regeneration within SCI sites. Up six different 3D were initially developed by rapid prototyping: bioplotting-based on biodegradable blend starch. These then further complemented injecting Gellan Gum,...
Abstract The control and manipulation of cells that trigger secondary mechanisms following spinal cord injury (SCI) is one the first opportunities to minimize its highly detrimental outcomes. Herein, ability surface‐engineered carboxymethylchitosan/polyamidoamine (CMCht/PAMAM) dendrimer nanoparticles intracellularly deliver methylprednisolone (MP) glial cells, allowing a controlled sustained release this corticosteroid in site, investigated. negatively charged MP‐loaded CMCht/PAMAM with...
Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number studies in humans concluded that pain-associated negative affect more pronounced when localized the left side body. It has been suggested such bias results from cortical function lateralization. not known, however, if other behavioral changes are differentially affected left- right-sided pain. To test this hypothesis, performance rats with unilateral spared nerve injury...
The idea that maladaptive stress impairs cognitive function has been a cornerstone of decades in basic and clinical research. However, disparate findings have reinforced the need to aggregate results from multiple sources order confirm validity such statement. In this work, systematic review meta-analyses were performed rodent studies investigating impact chronic on learning memory. Results obtained included revealed significant effect global performance. addition, stressed rodents presented...
Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies been proposed as viable alternative to current treatments used. Adipose tissue-derived stromal cells (ASCs) and olfactory ensheathing (OECs) used with promising results different models of SCI, namely due regenerative properties secretome first, guidance capability second. Using an vitro model...
Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)‐based approaches have been investigated for repairing this condition. Poly (3‐hydroxybutyrate‐ co ‐3‐hydroxyvalerate) (PHB‐HV) is found be particularly attractive TE applications due its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, report addresses the development characterization of PHB‐HV‐based 3D scaffolds, produced by freeze‐drying,...
Summary Dementia is the cardinal feature of Alzheimer's disease ( AD ), yet clinical symptoms this disorder also include a marked loss motor function. Tau abnormal hyperphosphorylation and malfunction are well‐established key events in neuropathology but impact normal function neuronal degeneration subsequent behavioral deficits still debated. While reduction has been increasingly suggested as therapeutic strategy against neurodegeneration, particularly , there controversial evidence about...
Background: Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat's emotional/cognitive behavior depending its left/right location; importantly, this observation recapitulates clinical reports. The prefrontal cortex (PFC), a brain region morphofunctionally affected in chronic pain conditions, is involved the modulation of both emotion and executive function displays functional lateralization. To test whether PFC lateralization bias associated with...
The use of dopamine replacement therapies (DRT) in the treatment Parkinson's disease (PD) can lead to development dysregulation syndrome (DDS) and impulse control disorders (ICD), behavioral disturbances characterized by compulsive DRT self-medication impulsive behaviors. However, mechanisms behind these are poorly understood. In animal models PD, assessment rewarding properties levodopa (LD), one most common drugs used has produced conflicting results, its ability promote increased...
Spine stabilization upon spinal cord injury (SCI) is a standard procedure in clinical practice, but rarely employed experimental models. Moreover, the application of biodegradable biomaterials for this would come as an advantage it eliminate presence nondegradable prosthesis within vertebral bone. Therefore, present work, we propose use new device specifically developed spine rat model SCI. A 3D scaffold based on blend starch with polycaprolactone was implanted, replacing delaminated...