A5058922507- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Immune Response and Inflammation
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrolyte and hormonal disorders
- Aquaculture disease management and microbiota
- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
- Axon Guidance and Neuronal Signaling
- Neurological Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- EEG and Brain-Computer Interfaces
University of Minho
2015-2024
Hospital Israelita Albert Einstein
2023-2024
Universidade Federal de Alfenas
2024
Clinical Academic Center of Braga
2013-2023
University of the Valley of Atemajac
2022
Universidade do Vale do Sapucaí
2022
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2022
John Wiley & Sons (United States)
2017-2021
Centre for Research in Anthropology
2020
University of Lisbon
2015-2020
Appropriate decision-making relies on the ability to shift between different behavioral strategies according context in which decisions are made. A cohort of subjects exposed prolonged stress, and respective gender- age-matched controls, performed an instrumental task assess their strategies. The stressed was reevaluated after a 6-week stress-free period. analysis complemented by functional magnetic resonance imaging (fMRI) study detect patterns activation corticostriatal networks ruling...
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs implicated in several relevant functions and present abnormal patterns many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little known about the effect of architecture RSNs, both conditions or during shift to task performance. Herein we assessed using a cohort...
There is accumulating evidence that the nucleus accumbens (NAc) has an important role in pathophysiology of depression. As NAc a key component neural circuitry reward, it been hypothesized anhedonia, core symptom depression, might be related to dysfunction this brain region. Neuronal morphology and expression plasticity-related molecules were examined rats displaying anhedonic behavior (measured sucrose-consumption test) response chronic mild stress. To demonstrate relevance our measurements...
Abstract Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from lack of dedicated and standardized neuroimaging tools, namely brain templates descriptive atlases. Here, we present two MRI their associated gray matter, white matter cerebrospinal fluid probability maps, generated ex vivo $${\mathrm{T}}_2^ \ast$$ <mml:math...
The choroid plexus, being part of the blood-brain barriers and responsible for production cerebrospinal fluid, is ideally positioned to transmit signals into out brain. This study, using microarray analysis, shows that mouse plexus displays an acute-phase response after inflammatory stimulus induced in periphery by lipopolysaccharide (LPS). Remarkably, specific a restricted number genes (out total 24,000 analyzed, 252 are up-regulated 173 down-regulated) transient, as it returns basal...
Although the gene expression profile of several tissues in humans and rodent animal models has been explored, analysis complete choroid plexus (CP) transcriptome is still lacking. A better characterization CP can provide key insights into its functions as one barriers that separate brain from periphery production cerebrospinal fluid.This work extends further what known about mouse through a microarray tissue normal mice under physiological conditions.We found genes most highly expressed are...
Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of first episode still lacking, but since early treatment leads to better prognosis, search for biomarkers needed. Here we characterized transcriptome choroid plexus (CP), which part blood-brain barriers (BBBs) and site cerebrospinal fluid production, experimental autoimmune encephalomyelitis (EAE) mouse model MS. In addition, samples from two...
Aims The association between the pathological features of AD and dementia is stronger in younger old persons than older suggesting that additional factors are involved clinical expression oldest old. Cumulative data suggests neuroinflammation plays a prominent role Alzheimer′s disease (AD) different studies reported an age‐associated dysregulation neuroimmune system. Consequently, we sought to characterize pattern microglial cell activation astrogliosis brain post mortem tissue...
Abstract An association between obesity and depression has been indicated in studies addressing common physical (metabolic) psychological (anxiety, low self-esteem) outcomes. Of consideration both are chronic mild stressors to which individuals exposed on a daily basis. However, the response stress is remarkably variable depending numerous factors, such as health mental state at time of exposure. Here (CMS) protocol was used assess effect high-fat diet (HFD)-induced rat model. In addition...
Lipocalin 2 (LCN2) is able to sequester iron-loaded bacterial siderophores and, therefore, known participate in the mammalian innate immune response. Of notice, LCN2 was shown display bacteriostatic effects both vitro and vivo. To reach brain, bacteria must cross blood-brain or choroid plexus (CP)/cerebrospinal fluid (CSF) barriers. Additionally, as CP responsible for production of most CSF, responses mediate signaling into brain. We show here that conditions peripheral inflammation, behaves...
Iron is essential for normal cellular homeostasis but in excess promotes free radical formation and detrimental. Therefore, iron metabolism tightly regulated. Here, we show that mechanisms regulating systemic may also control release into the brain at blood-choroid plexus-cerebrospinal fluid (CSF) barrier. Intraperitoneal administration of lipopolysaccharide (LPS) mice triggers a transient transcription gene encoding hepcidin, key regulator homeostasis, choroid plexus, which correlated with...
Abstract Background Chronic systemic inflammation triggers alterations in the central nervous system that may relate to underlying inflammatory component reported neurodegenerative disorders such as multiple sclerosis and Alzheimer's disease. However, it is far from being understood whether how peripheral contributes induce brain response illnesses. As part of barriers separate blood brain, choroid plexus conveys immune signals into largely through composition cerebrospinal fluid. Results In...