A5078171912- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Biochemical Acid Research Studies
- Lipid Membrane Structure and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- Sphingolipid Metabolism and Signaling
University of Minho
2014-2020
Abstract Lipids are major constituents of the brain largely implicated in physiological and pathological processes. The hippocampus is a complex structure involved learning, memory emotional responses, its functioning also affected various disorders. Despite conserved intrinsic circuitry, behavioral anatomical studies suggest existence structural functional gradient along hippocampal longitudinal axis. Here, we used an unbiased mass spectrometry approach to characterize lipid composition...
Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure and functioning. Based on previous work showing decreasing PA gradient along longitudinal axis rodent hippocampus, we asked whether dorsal hippocampus (DH) ventral (VH) are differentially affected by modulation. Here, show that phospholipase D1 (PLD1) major hippocampal source, compared to PLD2, PLD1 ablation affects predominantly lipidome DH. Moreover, Pld1 knockout (KO) mice specific deficits novel...
Phospholipase D (PLD) is a key player in the modulation of multiple aspects cell physiology and has been proposed as therapeutic target for Alzheimer's disease (AD). Here, we characterize PLD mutant, pld-1, using Caenorhabditis elegans animal model. We show that pld-1 animals present decreased phosphatidic acid levels, only source total activity are more sensitive to acute effects ethanol. further not essential survival or normal performance battery behavioral tests. Interestingly, both...
Phosphatidic acid (PA) is a central signaling lipid involved in the modulation of synaptic structure and functioning. Based on previous work showing decreasing gradient PA levels along longitudinal axis rodent hippocampus, we asked if dorsal (DH) ventral hippocampus (VH) are differentially affected by modulation. Here, show that phospholipase D1 (PLD1) major source hippocampal PA, comparatively to PLD2, PLD1 ablation affects predominantly lipidome DH rather than VH. Moreover, knock-out (KO)...