A5100751939- Stability and Controllability of Differential Equations
- Advanced Mathematical Modeling in Engineering
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- Advanced Mathematical Physics Problems
- Advanced Battery Materials and Technologies
- Nanoparticle-Based Drug Delivery
- Mechanical Behavior of Composites
- Numerical methods in engineering
- Composite Structure Analysis and Optimization
- Advanced Battery Technologies Research
- Advanced battery technologies research
- Advanced Sensor and Control Systems
- Numerical methods in inverse problems
- Electrocatalysts for Energy Conversion
- Hemoglobin structure and function
- Advanced Numerical Methods in Computational Mathematics
- Cancer-related molecular mechanisms research
- Luminescence and Fluorescent Materials
- Metallic Glasses and Amorphous Alloys
- Fusion materials and technologies
- Robotics and Sensor-Based Localization
- Computational Drug Discovery Methods
- Digital Media and Visual Art
- Advanced SAR Imaging Techniques
Northwestern Polytechnical University
2023-2025
China University of Mining and Technology
2024
Hangzhou Dianzi University
2017-2024
Xi'an Polytechnic University
2024
Heilongjiang University of Chinese Medicine
2024
Qinghai Normal University
2024
China Pharmaceutical University
2023
Shanghai Institute of Materia Medica
2023
Chinese Academy of Sciences
2014-2023
Civil Aviation University of China
2011-2023
Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies clinic. However, the widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide (TDI)-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used an intrinsic agent. As exploratory paradigm seeking biomedical applications, TDI was...
Abstract Long noncoding RNAs (lncRNAs) play important roles in various biological processes such as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA, named liver fibrosis-associated lncRNA1 (lnc-LFAR1), promotes fibrosis. We demonstrate lnc-LFAR1 silencing impairs hepatic stellate cells (HSCs) activation, reduces TGFβ-induced hepatocytes apoptosis vitro attenuates both CCl 4 - bile duct ligation-induced fibrosis mice. Lnc-LFAR1 the binding of Smad2/3...
Seawater electrolysis is a viable method for producing hydrogen on large scale and low-cost. However, the catalyst activity during seawater splitting process will dramatically degrade as salt concentrations increasing. Herein, CoP discovered that could reject chloride ions far from in electrolyte based molecular dynamic simulation. Thus, binder-free electrode designed constructed by in-situ growth of homogeneous rGO nanosheets wrapped around surface Ti fiber felt splitting. As expected,...
Drug, targeting ligand, and imaging agent are the three essential components in a nanoparticle-based drug delivery system. However, tremendous batch-to-batch variation of composition content typically accompany current approaches building these together. Herein, we report design photoactivatable platinum(IV) (Pt(IV)) amphiphiles containing one or two hydrophilic lactose ligands per hydrophobic Pt(IV) prodrug for an all-in-one precise nanomedicine. Self-assembly results either micelle vesicle...
A functional separator is designed by combining MXene quantum dots with g-C 3 N 4 sheets to regulate the kinetic behavior of polysulfides via capture–confinement–conversion.
Au–COF/rGO was designed to build a multifunctional interface, which can form an orderly connection between confinement–capture–conversion of polysulfides and promote the diffusion Li + , achieving outstanding performance Li–S batteries.
Integration of solar cell and secondary battery cannot only promote energy application but also improve the electrochemical performance battery. Lithium-sulfur (LSB) is an ideal candidate for photoassisted batteries owing to its high theoretical capacity. Unfortunately, researches related combination LSB are relatively lacking. Herein, a freestanding photoelectrode developed lithium-sulfur (PALSB) by constructing heterogeneous structured Au@N-TiO
Abstract Introducing metals into covalent organic frameworks (COFs) to synthesize metal‐COFs (MCOFs) presents novel opportunities for designing highly efficient catalysts address the sluggish conversion of polysulfides and developing effective ion calibrators mitigate uncontrolled lithium dendrite growth in lithium–sulfur batteries (LSBs). Herein, a facile one‐pot strategy is proposed integrate Zn single atoms COF framework through coordination with N O atoms. Comprehensive characterizations...
Forecasting of natural gas consumption has been essential for companies, customers, and governments. However, accurate forecasting is difficult, due to the cyclical change complexity factors that influence consumption. In this work, we constructed a hybrid artificial intelligence (AI) model predict short-term examine effects in cycle. The proposed combines factor selection algorithm (FSA), life genetic (LGA), support vector regression (SVR), namely, as FSA-LGA-SVR. FSA used select...
pH-sensitive polymeric micelles for targeted co-delivery of mitochondria-damaged proapoptotic peptide and DTX synergistic cancer therapy.
The hydrophobic patch of azurin (AZ) from Pseudomonas aeruginosa is an important recognition surface for electron transfer (ET) reactions. influence changing the size this region, by mutating C-terminal copper-binding loop, on ET reactivity AZ adsorbed gold electrodes modified with alkanethiol self-assembled monolayers (SAMs) has been studied. distance-dependence kinetics measured cyclic voltammetry using SAMs variable chain length, demonstrates that activation barrier short-range dominated...
Abstract Protein interactions are increasingly appreciated as targets in small‐molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important target. To obtain starting points for inhibitors of this interaction, three‐dimensional pharmacophore model was constructed from X‐ray crystal structure complex A2. represents favourable hydrophobic hydrogen bond two partners, well spatial receptor site constraints (excluded...
Composite materials are frequently exposed to external factors during their operational service, resulting in internal structural damage which subsequently impacts performance. This paper employs ferromagnetic for sensitivity magnetic field strength. By detecting variations the within embedded microwires of composite materials, aim is indirectly assess health status materials. Firstly, a theoretical numerical model intensity at crack site was established. Subsequently, finite element...
The main active-site loop of the copper-binding protein azurin (a cupredoxin) has been shortened from C(112)TFPGH(117)SALM(121) to C(112)TPH(115)PFM(118) (the native cupredoxin amicyanin) and also C(112)TPH(115)PM(117). Cu(II) site structure is almost unaffected by shortening, as that Cu(I) center at alkaline pH in variant with C(112)TPH(115)PM(117) sequence. Subtle spectroscopic differences due alterations spin density distribution can be attributed mainly changes hydrogen-bonding pattern....
Although the interferon α (IFNα) signaling and paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in progression of breast cancer (BCa), it remains obscure whether these two pathways act a coordinated manner. We therefore aimed to elucidate expression function PITX2 during pathogenesis endocrine resistance BCa.PITX2 was assessed BCa tissues using quantitative reverse polymerase chain reaction (RT-qPCR) immunohistochemistry experimentally induced...