A5101531347- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Iron Metabolism and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- Healthcare and Venom Research
- Chemical Synthesis and Analysis
- T-cell and B-cell Immunology
- PI3K/AKT/mTOR signaling in cancer
- Venomous Animal Envenomation and Studies
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- melanin and skin pigmentation
- Caveolin-1 and cellular processes
- Erythropoietin and Anemia Treatment
- Genomics and Rare Diseases
- Chemical Reactions and Isotopes
- Chemokine receptors and signaling
- Neurofibromatosis and Schwannoma Cases
- Bee Products Chemical Analysis
- Metabolism, Diabetes, and Cancer
Huazhong University of Science and Technology
2023
Union Hospital
2023
China Pharmaceutical University
2008-2022
The First People's Hospital of Xiaoshan District, Hangzhou
2020
Southern Medical University
2013-2017
University Hospital Cologne
2017
Shandong University
2013-2016
Jinan Central Hospital
2014-2016
Army Medical University
2015
Southwest Hospital
2015
Hemoglobin (Hb) A production during red blood cell development is coordinated to minimize the deleterious effects of free alpha- and beta-Hb subunits, which are unstable cytotoxic. The alpha-Hb-stabilizing protein (AHSP) an erythroid that specifically binds alpha-Hb prevents its precipitation in vitro, suggests it may function limit toxicities vivo. We investigated this possibility through gene ablation biochemical studies. AHSP(-/-) erythrocytes contained hemoglobin precipitates were...
Erythrocyte precursors produce abundant α- and β-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier. αHb-stabilizing protein (AHSP) binds free α subunits reversibly maintain their structure limit ability generate reactive species. Accordingly, loss of AHSP aggravates toxicity excessive α-globin caused by gene disruption in mice. Surprisingly, we found that also has important functions when is limited. Thus, compound mutants lacking both...
Introduction Psoriasis is a common inflammatory skin disease recognized by the World Health Organization as "an incurable chronic, noninfectious, painful, disfiguring and disabling disease." The fact that metabolic syndrome (MetS) most important comorbidities of psoriasis suggests an role lipid metabolism in pathogenesis psoriasis. Narciclasine (Ncs) alkaloid isolated from Amaryllidaceae plants. Its biological activities include antitumor, antibacterial, antiinflammatory, anti-angiogenic...
Abstract Background Gastric cancer is a leading causes of cancer-related deaths ,but the underlying molecular mechanisms its progression are largely unknown. Differentiated embryonic chondrocyte-expressed gene 1 (DEC1), an important transcription factor involved in tumors and has recently been identified to be strongly inducible by hypoxia. Little known about contribution DEC1 intracellular hypoxia proliferation signaling events gastric cancer. Methods Immunohistochemistry was used detect...
Abstract Vitiligo is a common depigmentary skin disease that may follow pattern of multifactorial inheritance. The essential factors its immunopathogenesis thought to be the selective destruction melanocytes. As new class microregulators gene expression, mi RNA have been reported play vital roles in autoimmune diseases, metabolic diseases and cancer. This study sought characterize different expression peripheral blood mononuclear cells ( PBMC ) patients with non‐segmental vitiligo NSV...
// Le Yu 1 , William K.K. Wu 2, 3 Chunping Gu 1, 4 Desheng Zhong Xuyan Zhao Yi Kong Qinghuan Lin Matthew T.V. Chan 2 Zhitao Zhou 5 Shuwen Liu State Key Laboratory of Organ Failure Research, Guangdong Provincial New Drug Screening, School Pharmaceutical Sciences, Southern Medical University, Guangzhou, China Department Anaesthesia and Intensive Care, The Chinese University Hong Kong, Digestive Diseases, LKS Institute Health Nanfang Hospital, Electron Microscopy Laboratory, Correspondence to:...
Several Escherichia coli pathotypes still constitute an important public health concern owing to its pathogenicity and antimicrobial resistance. Moreover, biofilm formation of E. can allow the strains interfere with host eradication, thus conferring additional The association between resistance determinants has been extensively exploited; nevertheless, there is no definite conclusion. purpose this study was provide data augment present knowledge about subject.Antibiotic...
Gastric cancer (GC) is a common and deadly digestive tract tumor worldwide. Unfortunately, diagnosis of GC usually confused misleading because atypical symptoms or incomplete complaints. Accordingly, exploring gene expression profile identifying genes with analogical variance trend will bring new perspective into the treatment GC. Herein, RNA‑Seq dataset from Caucasian their matched non‑cancerous samples [Gene Expression Omnibus (GEO): SRP049809] datasets four microarrays constituted...
Despite its successful use in academic research, next-generation sequencing (NGS) still represents many challenges for routine clinical adoption due to inherent complexity and specialised expertise typically required set-up, test operate a complete workflow.This study aims evaluate QIAGEN's newly launched GeneReader NGS System solution pathology laboratory setting by assessing the system's ease of use, accuracy data reproducibility. Our was able implement system validate performance using...
The detection of somatic mutations in primary tumors is critical for the understanding cancer evolution and targeting therapy. Multiple technologies have been developed to enable such mutations. Next generation sequencing (NGS) a new platform that gradually becoming technology choice genotyping samples, owing its ability simultaneously interrogate many genomic loci at massively high efficiency increasingly lower cost. However, multiple barriers still exist broader adoption clinical research...
Hemoglobin (Hb) A production during red blood cell development is coordinated to minimize the deleterious effects of free α- and β-Hb subunits, which are unstable cytotoxic. The α-Hb–stabilizing protein (AHSP) an erythroid that specifically binds α-Hb prevents its precipitation in vitro, suggests it may function limit toxicities vivo. We investigated this possibility through gene ablation biochemical studies. AHSP–/– erythrocytes contained hemoglobin precipitates were short-lived. In...
Dropping during shipping and handling of liquid biopharmaceutical formulations has long been known to cause protein degradation aggregation. On the other hand, accidental dropping freeze-dried is generally considered not a major issue for quality. Reports stability especially underling mechanism(s) were rarely seen in literature. In this manuscript, we report an interesting phenomenon which repeated monoclonal antibody X (mAb-X) formulation powder resulted significant sub-visible particles...