A5008262373- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- Phytochemical compounds biological activities
- Computational Drug Discovery Methods
- Gut microbiota and health
- Marine Sponges and Natural Products
- Reproductive tract infections research
- Synthesis and Biological Activity
- Pharmacological Effects and Toxicity Studies
- Fungal Biology and Applications
- Lipoproteins and Cardiovascular Health
- Dialysis and Renal Disease Management
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Phytochemistry and biological activity of medicinal plants
- Biochemical and Structural Characterization
- Alkaloids: synthesis and pharmacology
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Protein Kinase Regulation and GTPase Signaling
- Vitamin C and Antioxidants Research
Southern Medical University Shenzhen Hospital
2020-2025
Southern Medical University
2014-2023
Nanfang Hospital
2019-2020
Guangdong Pharmaceutical University
2017
Xiangtan University
2013
Purpose: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on regulation gut microbiota and colonic microenvironment CKD. Methods: CKD rats were induced by 150 mg/kg adenine gavage 4 weeks, then orally treated with or without 3.6 g/kg 7.2 HGF 8 weeks. The renal function structure analyzed biochemical detection, hematoxylin eosin, Masson’s trichrome, Sirius red immunochemical staining. Average fecal...
Marine micro-organisms have been proven to be excellent sources of bioactive compounds against HIV-1. Several natural products obtained from marine-derived Aspergillus fungi were screened for their activities inhibit HIV-1 infection. Penicillixanthone A (PXA), a xanthone dimer jellyfish-derived fungus fumigates, displayed potent anti-HIV-1 activity by inhibiting infection CCR5-tropic SF162 and CXCR4-tropic NL4-3, with IC50 0.36 0.26 μM, respectively. Molecular docking study was conducted...
Influenza A viral (IAV) fusion peptides are known for their important role in viral-cell process and membrane destabilization potential which compatible with those of antimicrobial peptides. Thus, by replacing the negatively or neutrally charged residues FPs positively lysines, we synthesized several potent derived from fusogenic (FPs) hemagglutinin glycoproteins (HAs) IAV. The biological screening identified that addition to antibacterial activities, these (pFPs) effectively inhibited...
Abstract Pan‐Bcl‐2 family inhibitor obatoclax has been demonstrated to be effective against various cancers, of which the mechanism action is not fully understood. In this study, we demonstrate that suppressed esophageal cancer cell viability with concomitant G1/G0‐phase cycle arrest. At tested concentrations (1/2 IC 50 and ), neither induced PARP cleavage nor increased Annexin V‐positive population, suggesting arrest rather than apoptosis accounts for most reduction produced by obatoclax....
Semen-derived enhancer of viral infection (SEVI) is composed amyloid fibrils that can greatly enhance HIV-1 infectivity. By its cationic property, SEVI promotes sexual transmission by facilitating the attachment and internalization to target cells. Therefore, semen-derived are potential targets for microbicide design. ADS-J1 an anionic entry inhibitor. In this study, we explored additional function ADS-J1: inhibition fibril formation blockage SEVI-mediated enhancement infection. We found...
The antifungal agent voriconazole (VRC) exhibits extreme inter-individual and intra-individual variation in terms of its clinical efficacy toxicity. Inflammation, as reflected by C-reactive protein (CRP) concentrations, significantly affects the metabolic ratio trough concentrations voriconazole. Bacteroides fragilis ( B. ) is an important component human intestinal microbiota. Clinical data have shown that abundance comparatively higher patients not presenting with adverse drug reactions,...
Acute myeloid leukaemia (AML) is a malignant disease of hematopoietic stem/progenitor cells. Despite improved understanding the pathogenesis AML since 1980s, standard treatment for has remained virtually unchanged. Numerous studies have found poor survival rates and high relapse among older patients with AML. Several novel therapies AML, including cytotoxic drugs, genetically- epigenetically-targeted immunotherapies, been developed in recent years. Alternative treatments efficacy are...
Semen is a major vehicle for HIV transmission. Prostatic acid phosphatase (PAP) fragments, such as PAP248-286, in human semen can form amyloid fibrils to enhance infection. Other endogenous or exogenous factors present during sexual intercourse have also been reported promote the formation of seminal fibrils.Here, we demonstrated that synthetic 15-residue peptide derived from HIV-1 gp120 coreceptor-binding region, designated enhancing 2 (EP2), rapidly self-assemble into nanofibers. These...
Uremic toxin accumulation is one possible reason for alterations in hepatic drug metabolism patients with chronic kidney disease (CKD). However, the types of uremic toxins and underlying mechanisms are poorly understood. In this study, we report role advanced oxidation protein products (AOPPs), a modified toxin, downregulation cytochromes P450 1A2 (CYP1A2) 3A4 (CYP3A4) expression levels activities. We found that AOPP plasma rat CKD model was associated decreased CYP1A2 CYP3A4. CYP3A4...
Purpose: Voriconazole (VOR) is combined with atorvastatin (ATO) to treat fungal infections in patients dyslipidemia clinical practice. However, the pharmacokinetic interactions and potential mechanisms between them are unknown. Therefore, this study aimed investigate ATO VOR. Patients methods: We collected plasma samples from three using Rats were administered either VOR or normal saline for 6 days, followed by a single dose of 2 mg/kg ATO, then at different time points. The incubation...
Semen Strychni, a known toxic drug in Chinese pharmacopoeia, is notable for its therapeutic effects on local muscle and joint pain. However, oral administration can be risky. Topically administered drugs accumulate the topical muscles knee joints without any major increase plasma levels; only non‐protein‐bound biological fluids of target tissues are effective effects. A sensitive rapid ultra performance liquid chromatography ‐ mass spectrometry (UPLC‐MS) method coupled with microdialysis...
Based on the marine natural products piperafizine B, XR334, and our previously reported compound 4m, fourteen novel 3,6-diunsaturated 2,5-diketopiperazine (2,5-DKP) derivatives (1, 2, 4-6, 8-16), together with two known ones (3 7), were designed synthesized as anticancer agents against A549 Hela cell lines. The MTT assay results showed that 6, 8-12, 14 had moderate to good capacities, IC50 values ranging from 0.7 8.9 μM. Among them, 11, naphthalen-1-ylmethylene 2-methoxybenzylidene functions...
Based on the marine natural products piperafizine B, X334 and our previously reported compound 4m, fourteen novel 3,6-diunsaturated 2,5-diketopiperazine (2,5-DPK) derivatives (1-2, 4-6, 8-16), together with two known ones (3 7), were designed synthesized as anticancer agents against cell lines A549 Hela. The MTT assay results showed that 6, 8-12 15 had moderate to good capacities IC50 values ranging from 0.7 8.9 μM. Among them, 11 naphthalen-1-ylmethylene 2-methoxybenzylidene functions at 3-...