A5076442862- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacogenetics and Drug Metabolism
- Lymphoma Diagnosis and Treatment
- Healthcare and Venom Research
- Insect symbiosis and bacterial influences
- Insect Utilization and Effects
- Neurological Complications and Syndromes
- Biochemical and Molecular Research
- Insect Resistance and Genetics
- Traditional Chinese Medicine Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell Adhesion Molecules Research
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
Zunyi Medical University
2021-2025
Johns Hopkins Medicine
2022-2024
Johns Hopkins University
2017-2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Jilin University
2024
University of Alberta
2018-2023
Southern Medical University Shenzhen Hospital
2018-2023
Wuhan Polytechnic University
2021-2023
Kunming Municipal Hospital of Traditional Chinese Medicine
2023
Background & AimsOne of the features ulcerative colitis (UC) is a defect in protective mucus layer. This has been attributed to reduced number goblet cells (GCs). However, it not known whether abnormal GC secretion also contributes Our aims were investigate was UC and exists as long-term effect chronic inflammation.MethodsColonoids established from intestinal stem healthy subjects (HS) patients with UC. Colonoids maintained undifferentiated (UD) or induced differentiate (DF) studied...
Life tables are indispensable in IPM, offering an analysis of insect population dynamics. These record survival rates, fecundity, and other parameters at various developmental stages, enabling the identification key factors that affect numbers prediction growth trajectories. This review discusses application life agricultural pest management, including assessment control capacity natural enemies, evaluation biological agents, screening insect-resistant plant species. In vector control, used...
After eight generations of laboratory selection with β-cypermethrin, a P. okadai strain was cultivated that displayed 10.04-fold increase in resistance (RS) relative to the susceptible (SS), an estimation heritability (h2) 0.34. Compared SS, developmental duration eggs significantly prolonged (p < 0.05); however, pupal stage shorter, no statistically significant difference. Moreover, levels GSTs, CarEs, and CYP450 activity were notably higher RS than SS. In addition, level CarE midgut...
There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated proneoplastic esophageal adenocarcinoma (EAC)-derived EVs gastric organoids (gastroids) and elucidated molecular mechanisms underlying these effects. were identified using PKH-67 staining. Morphologic changes, Ki-67 immunochemistry, cell viability, growth rates, expression levels miR-25 miR-210, as well their target mRNAs,...
The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for generation these metabolites. Experiments were conducted HepaRG cells utilizing following markers cellular toxicity: 2′-7′-dichlorofluorescein (DCF; oxidative stress) formation, total glutathione (GSH) concentration, and lactate dehydrogenase (LDH; necrosis) release. Concentrations p-cresol, sulfate,...
Resistance to chemotherapeutic medicines complicates and eventually kills people with ovarian cancer. Nafamostat mesylate (NM) has been used as an adjuvant therapy enhance chemotherapy sensitivity in several cancers. This study aimed evaluate the effect of NM on cancer cells susceptible carboplatin (CBP) determine underlying mechanism involved. Herein, qRT-PCR, western blot, IHC were analyze mRNA protein expression. Cell viability proliferation measured using MTT colony formation assays....
Abstract p-Cresol is a uremic toxin that formed by intestinal microbiota and extensively conjugated first-pass metabolism. glucuronide exerts various forms of cellular toxicity in vitro accumulated the plasma subjects with kidney disease, where associations adverse cardiovascular renal outcomes are evident. The objective this study was to determine contributions human UDP-glucuronosyltransferase (UGT) enzymes formation p-cresol glucuronide. Utilizing commonly expressed hepatic or recombinant...
Introduction and aim. To investigate the association of adolescent obesity with nonalcoholic fatty liver disease (NAFLD) related risk factors in Xi 'an, China. Material methods. A total 4141 adolescents (2,061 girls 2,080 boys, mean age: 18.62 ± 0.66 years, age range 15-22 years) were enrolled this investigation. Anthropometric index was measured, ultrasonography function biochemical test performed all subjects. T test, χ2 logistic regression analysis used for statistical analyses. Results....
Abstract Background Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. At present, existing treatments cannot change risk factors for occurrence disease, so patients are prone to fear progression or recurrence, and studies have shown that excessive will cause over-examine, mental abnormalities, suicide other behaviors, increase unnecessary medical care costs social burden. Thus investigate current situation in with Myocardial Infarction admitted...
Background Methylmalonic aciduria (MMA) is the most frequent disease of organic in China. Various biochemical strategies are followed for prenatal diagnosis MMA. However, since fetuses affected by MMA have decreased excretion methylmalonic acid, difficulties obvious. Gas chromatography mass spectrometry (GC/MS) and tandem (ESI/MS/MS) allowed us to identify fetuses. The aim this study was determine value analysis acids total homocysteine amniotic fluid Methods clinical diagnoses outcomes nine...
Abstract A 57‐year‐old man who suffered from a headache for 1 year, accompanied by blurred vision 7 months and numbness in his left face week was admitted to the Affiliated Hospital of Zunyi Medical University on May 7, 2022. One year ago, patient had no obvious precipitating factor paroxysmal stabbing pain whole skull with dizziness, which could be relieved oneself after lasting 1–2 min each time, about 20 episodes per day. The cranial magnetic resonance imaging revealed changes bilateral...
Abstract Lack of understanding the pathophysiology gastrointestinal (GI) complications in type 1 diabetes (T1D), including altered intestinal transcriptomes and protein expression represents a major gap management these patients. Human enteroids have emerged as physiologically relevant model epithelium but establishing from individuals with long-standing T1D has proven difficult. We successfully established duodenal using endoscopic biopsies pediatric patients compared them aged-matched...
A 40-year-old man presented with painless sudden visual loss due to a central retinal artery occlusion (CRAO) in his right eye. Three months later, he had acute left eye acuity of 20/100 and swollen optic disc. After oral prednisone treatment, the disc swelling resolved recovered 20/20. Five patient experienced another episode vision associated edema. With steroid therapy, regained 20/20 once again. history recurrent ulcers, fluorescein angiography showing obliterative vasculitis eye,...
Paeoniflorin (PF) is the chief active component of paeonia, with diverse pharmacological actions and wide application. Recently, effect PF on nervous system has attracted increasingly more attention. According to current study findings, can ameliorate decline memory learning capacities in many dementia model animals, have protecting cerebral ischemia injury, treating Parkinson's disease, reliving pain improving neural synapse plasticity. Thought its mechanism not been clarified, findings...