A5100663714- Neonatal and Maternal Infections
- Gut microbiota and health
- Foot and Ankle Surgery
- Antifungal resistance and susceptibility
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Orthopedic Surgery and Rehabilitation
- Eicosanoids and Hypertension Pharmacology
- Psoriasis: Treatment and Pathogenesis
- Antibiotics Pharmacokinetics and Efficacy
- Neuroblastoma Research and Treatments
- Pharmacogenetics and Drug Metabolism
- Medicinal Plant Pharmacodynamics Research
- Neonatal and fetal brain pathology
- Lower Extremity Biomechanics and Pathologies
- Antibiotic Use and Resistance
- Structural Behavior of Reinforced Concrete
- NF-κB Signaling Pathways
Henan Normal University
2025
Longgang Central Hospital
1998-2025
Guangdong Medical College
2021-2025
Shandong Provincial Hospital
2020-2024
Southern Medical University Shenzhen Hospital
2021-2024
Guangdong Pharmaceutical University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Beijing University of Chinese Medicine
2024
Xiyuan Hospital
2024
Shandong First Medical University
2021-2024
Abstract We present a comprehensive analysis of the submissions to first edition Endoscopy Artefact Detection challenge (EAD). Using crowd-sourcing, this initiative is step towards understanding limitations existing state-of-the-art computer vision methods applied endoscopy and promoting development new approaches suitable for clinical translation. routine imaging technique detection, diagnosis treatment diseases in hollow-organs; esophagus, stomach, colon, uterus bladder. However nature...
Abstract Aim Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related therapies. We aimed to identify regulators of diabetic Methods results Mass spectrometry-based, non-targeted metabolomic approach was used profile coronary sinus blood from non-diabetic Bama-mini pigs at 0.5-h post artery ligation. Six metabolites had a |log 2 (Fold Change)|> 1.3. Among them, most changed arachidonic acid (AA),...
Kidney cancer is a highly lethal cancer, of which the most common type renal cell carcinoma (RCC). The targeted drugs used in treating RCC clinically have lot side effects. Therefore, it urgent to find out effective agents with little toxic effects.The antiproliferation effect chlorogenic acid (CA) was performed using CCK-8 assay. Then, we adopted colony formation assay, Annexin V/PI staining assay and JC-1 mitochondrial membrane potential explore mechanism anticancer CA. We also conducted...
The purpose of this study was to investigate the effect intestinal dysbiosis on bioavailability voriconazole and explore any underlying mechanisms. Sprague-Dawley rats were randomly divided into two groups: a normal control group ceftriaxone-associated dysbiotic group. composition flora examined using 16S rRNA sequencing analysis. Voriconazole concentrations determined by high-performance liquid chromatography-tandem mass spectrometry. Outer membrane vesicles (OMVs) microbes from different...
Background Inflammatory diseases impair the hepatic metabolism of voriconazole (VRC). 1-Methylnicotinamide (1-MNA), a common final metabolite nicotinamide in liver, has demonstrated anti-inflammatory effects recent studies. This study investigated impact 1-MNA on VRC liver. Method Mice with systemic inflammatory response induced by lipopolysaccharide (LPS) were intragastrically administered 1-MNA, and their metabolic capacity was evaluated. Kupffer cells primary hepatocytes isolated, flow...
Voriconazole (VRC), a widely used antifungal drug, often causes hepatotoxicity, which presents significant clinical challenge. Previous studies demonstrated that
Non-small cell lung cancer (NSCLC) is the most common worldwide. MicroRNAs have been shown to be correlated with biological processes of various tumors. In this study, we observed that expression miR-582-5p was lower in NSCLC tissues than para-carcinoma tissues. Ectopic significantly inhibited NCI-H358 proliferation and invasion. Knockdown showed opposite results, growth rate invasive capacity PC-9 cells enhanced. Furthermore, elucidated NOTCH1 a target there an inverse correlation between...
Purpose: This study aims to investigate the effects of Huang Gan formula (HGF), a Chinese herbal prescription used for chronic kidney disease (CKD), on regulation gut microbiota and colonic microenvironment CKD. Methods: CKD rats were induced by 150 mg/kg adenine gavage 4 weeks, then orally treated with or without 3.6 g/kg 7.2 HGF 8 weeks. The renal function structure analyzed biochemical detection, hematoxylin eosin, Masson’s trichrome, Sirius red immunochemical staining. Average fecal...
Two new oleanolic acid saponins, namely celosin A (1) and B (2), together with six known compounds, stigmasterol, β-sitosterol, β-daucosterol, hexacosoic acid, palmitic stearic were isolated from the ethanolic extract of Semen celosiae. The structures (2) determined by spectral analysis (including 1D- 2D-NMR). hepatoprotective activity 1 2 oral doses 1.0, 2.0 4.0 mg kg⁻¹ investigated carbon tetrachloride CCl₄-induced hepatotoxicity in mice. results indicate that they have significant...
The antifungal agent voriconazole (VRC) exhibits extreme inter-individual and intra-individual variation in terms of its clinical efficacy toxicity. Inflammation, as reflected by C-reactive protein (CRP) concentrations, significantly affects the metabolic ratio trough concentrations voriconazole. Bacteroides fragilis ( B. ) is an important component human intestinal microbiota. Clinical data have shown that abundance comparatively higher patients not presenting with adverse drug reactions,...
Background. Hepatocellular carcinoma (HCC) is aggressive cancer with a poor prognosis. It has been suggested that the aberrant expression of LOXL2 associated development HCC, but exact mechanism remains unclear. This research aimed at examining level and prognostic value in hepatocellular its relationship immune infiltration predicting upstream noncoding RNAs (ncRNAs). Method. The transcriptome data HCC was first downloaded from Cancer Genome Atlas (TCGA) database to investigate prognosis...
Acute myeloid leukaemia (AML) is a malignant disease of hematopoietic stem/progenitor cells. Despite improved understanding the pathogenesis AML since 1980s, standard treatment for has remained virtually unchanged. Numerous studies have found poor survival rates and high relapse among older patients with AML. Several novel therapies AML, including cytotoxic drugs, genetically- epigenetically-targeted immunotherapies, been developed in recent years. Alternative treatments efficacy are...
This study explores the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix (ECM) accumulation and inflammation in diabetic nephropathy (DN) underlying mechanisms.DN rats, induced via high-fat diet/streptozotocin, were used to assess effects VX-765. Parallel experiments carried out rat mesangial cell line HBZY-1 exposed high glucose (HG) reveal molecular mechanism VX-765 preventing DN. Survival analysis, biochemical parameters renal oxidative stress rats...
Inflammatory bowel diseases (IBDs) are increasingly recognized as a pressing global health concern. The gut microbiome emerges both potential therapeutic target and repository for pharmacological interventions in IBDs management. This perspective aims to elucidate the pivotal findings from recent studies concerning anti-inflammatory properties of microbiota-derived metabolites (GMDMs), dissect strengths challenges GMDMs treatment strategies IBDs, highlight integral role nuclear receptors...